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Protein

Ras-related protein Rab-6.1

Gene

rab-6.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6.1
Gene namesi
Name:rab-6.1
ORF Names:F59B2.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF59B2.7; CE00234; WBGene00004269; rab-6.1.

Subcellular locationi

GO - Cellular componenti

  • cortical granule Source: WormBase
  • cytoplasm Source: WormBase
  • cytosol Source: GOC
  • Golgi cisterna Source: WormBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211181 – 205Ras-related protein Rab-6.1Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi203S-geranylgeranyl cysteineBy similarity1
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP34213.
PaxDbiP34213.
PRIDEiP34213.

Expressioni

Gene expression databases

BgeeiWBGene00004269.

Interactioni

Protein-protein interaction databases

BioGridi41474. 1 interactor.
IntActiP34213. 1 interactor.
STRINGi6239.F59B2.7.1.

Structurei

3D structure databases

ProteinModelPortaliP34213.
SMRiP34213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
InParanoidiP34213.
OMAiPNIVIMN.
OrthoDBiEOG091G0ORZ.
PhylomeDBiP34213.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFTNNALK KFKLVFLGEQ SVGKTSIITR FMYDSFDNTY QATIGIDFLS
60 70 80 90 100
KTMYLEDRTI RLQLWDTAGQ ERFRSLIPSY IRDSSVAVVV YDITNANSFH
110 120 130 140 150
QTTKWVDDVR NERGCDVIIV LVGNKTDLAD KRQVSTEDGE KKARDLNVMF
160 170 180 190 200
IETSAKAGYN VKQLFRKIAT ALPGIVQEET PEQPNIVIMN PPKDAEESQG

RQCPC
Length:205
Mass (Da):23,259
Last modified:February 1, 1994 - v1
Checksum:iA8A0876CF8E456C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11505 Genomic DNA. Translation: CAA77590.1.
PIRiS31127.
RefSeqiNP_498993.1. NM_066592.4.
UniGeneiCel.10374.

Genome annotation databases

EnsemblMetazoaiF59B2.7; F59B2.7; WBGene00004269.
GeneIDi176275.
KEGGicel:CELE_F59B2.7.
UCSCiF59B2.7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11505 Genomic DNA. Translation: CAA77590.1.
PIRiS31127.
RefSeqiNP_498993.1. NM_066592.4.
UniGeneiCel.10374.

3D structure databases

ProteinModelPortaliP34213.
SMRiP34213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41474. 1 interactor.
IntActiP34213. 1 interactor.
STRINGi6239.F59B2.7.1.

Proteomic databases

EPDiP34213.
PaxDbiP34213.
PRIDEiP34213.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59B2.7; F59B2.7; WBGene00004269.
GeneIDi176275.
KEGGicel:CELE_F59B2.7.
UCSCiF59B2.7.1. c. elegans.

Organism-specific databases

CTDi176275.
WormBaseiF59B2.7; CE00234; WBGene00004269; rab-6.1.

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
InParanoidiP34213.
OMAiPNIVIMN.
OrthoDBiEOG091G0ORZ.
PhylomeDBiP34213.

Miscellaneous databases

PROiP34213.

Gene expression databases

BgeeiWBGene00004269.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB6A_CAEEL
AccessioniPrimary (citable) accession number: P34213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.