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Protein

Deoxyribodipyrimidine photo-lyase

Gene

phr

Organism
Carassius auratus (Goldfish)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.

Catalytic activityi

Cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei333DNABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi478 – 480FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Lyase
Biological processDNA damage, DNA repair
LigandChromophore, FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribodipyrimidine photo-lyase (EC:4.1.99.3)
Alternative name(s):
DNA photolyase
Photoreactivating enzyme
Gene namesi
Name:phr
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851191 – 556Deoxyribodipyrimidine photo-lyaseAdd BLAST556

Proteomic databases

PRIDEiP34205

Expressioni

Inductioni

By visible light.

Structurei

3D structure databases

ProteinModelPortaliP34205
SMRiP34205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 240Photolyase/cryptochrome alpha/betaAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni378 – 386Interaction with DNABy similarity9
Regioni452 – 453Interaction with DNABy similarity2

Sequence similaritiesi

Belongs to the DNA photolyase class-2 family.Curated

Phylogenomic databases

HOVERGENiHBG008186

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR036134 Crypto/Photolyase_FAD-like_sf
IPR036155 Crypto/Photolyase_N_sf
IPR008148 DNA_photolyase_2
IPR032673 DNA_photolyase_2_CS
IPR006050 DNA_photolyase_N
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00875 DNA_photolyase, 1 hit
SUPFAMiSSF48173 SSF48173, 1 hit
SSF52425 SSF52425, 1 hit
TIGRFAMsiTIGR00591 phr2, 1 hit
PROSITEiView protein in PROSITE
PS01083 DNA_PHOTOLYASES_2_1, 1 hit
PS01084 DNA_PHOTOLYASES_2_2, 1 hit
PS51645 PHR_CRY_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

P34205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGECMLHIR LFSTNLYIRS TLLRSVSDPN TLLHYCSMSA NKRKLKRQRE
60 70 80 90 100
SPDSGGGKQP RLAEGRARES GWLLREVNEL RRAAQGCEVN KKRLRYLSDT
110 120 130 140 150
QKIKQGSDGF LYWMSRDQRV QDNWALIYAQ QLALAEKLPL HICFCLVPRY
160 170 180 190 200
LDATYRQYAF MLKGLQEVAK ECKSLDIQFH LLSGEPGQNL PSFVEKWKFG
210 220 230 240 250
AVVTDFNPLR IPLQWIETVK KHLPADVPFI QVDAHNVVPC WEASGKLEYG
260 270 280 290 300
ARTIRGKITK LLPEFLTEIP LVDTHPHSAS RAAEPVDWEE VLSSLEVERS
310 320 330 340 350
VGEVDWAQPG TSGGMNMLES FIDQRLRLFA THRNNPNYDA LSHLSPWIHT
360 370 380 390 400
GQLSAQRVVK QVKREKNASE SVASFIEELV VRRELADNFC FYNPSYDNIS
410 420 430 440 450
GAYDWAKKTL QDHAKDSRQY LYTKEQLENA KTHDQLWNAA QRQLVSEGKM
460 470 480 490 500
HGFLRMYWAK KILEWTASPE EALSIAIYLN DRLSLDGCDP NGYVGCMWSI
510 520 530 540 550
CGIHDQGWAE RPIFGKIRFM NYAGCKRKFD VAQFERKYTA VKENSNKDSK

KSSSKN
Length:556
Mass (Da):63,868
Last modified:February 1, 1994 - v1
Checksum:i28318FB406DC5646
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11391 mRNA Translation: BAA01987.1
PIRiA45098

Similar proteinsi

Entry informationi

Entry nameiPHR_CARAU
AccessioniPrimary (citable) accession number: P34205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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