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P34198 (COX3_FORLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:mt-co3
Synonyms:coiii, coxiii, mtco3
Encoded onMitochondrion
OrganismFormosania lacustris (Oriental stream loach) (Crossostoma lacustre)
Taxonomic identifier7980 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Balitoridae › Balitorinae › Formosania

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Cytochrome c oxidase subunit 3
PRO_0000183760

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane31 – 5121Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P34198 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 6D397A7F5B5A4A24

FASTA26129,511
        10         20         30         40         50         60 
MAHQAHAYHM VDPSPWPLTG AIGALFLTSG LAIWFHFQSV TLLTLGLILL LLTMYQWWRD 

        70         80         90        100        110        120 
IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA FYHSSLAPTP ELGGCWPPTG 

       130        140        150        160        170        180 
ITPLDPFEVP LLNTAVLLAS GVTVTWAHHS LMEGARKQAI QALALTIILG VYFTALQAME 

       190        200        210        220        230        240 
YYEAPFTIAD GVYGSTFFVA TGFHGLHVII GSSFLAVCLL RQIQYHFTSE HHFGFEAAAW 

       250        260 
YWHFVDVVWL FLYVSIYWWG S

« Hide

References

[1]"The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome: conservation and variations among vertebrates."
Tzeng C.-S., Hui C.-F., Shen S.-C., Huang P.C.
Nucleic Acids Res. 20:4853-4858(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Tzeng C.-S.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M91245 Genomic DNA. Translation: AAB96817.1.
PIRS60277.
RefSeqNP_008309.1. NC_001727.1.

3D structure databases

ProteinModelPortalP34198.
SMRP34198. Positions 1-261.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID807994.

Organism-specific databases

CTD4514.

Phylogenomic databases

HOVERGENHBG016686.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. CytC_oxdse_III. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_FORLA
AccessionPrimary (citable) accession number: P34198
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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