Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P34189 (COX2_FORLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:mt-co2
Synonyms:coii, coxii, mtco2
Encoded onMitochondrion
OrganismFormosania lacustris (Oriental stream loach) (Crossostoma lacustre)
Taxonomic identifier7980 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesBalitoridaeFormosania

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Cytochrome c oxidase subunit 2
PRO_0000183558

Regions

Topological domain1 – 2626Mitochondrial intermembrane Potential
Transmembrane27 – 4822Helical; Potential
Topological domain49 – 6214Mitochondrial matrix Potential
Transmembrane63 – 8220Helical; Potential
Topological domain83 – 230148Mitochondrial intermembrane Potential

Sites

Metal binding1611Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable
Metal binding2041Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P34189 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 73D11DE016194329

FASTA23026,093
        10         20         30         40         50         60 
MAHPTQLGFQ DAASPVMEEL LHFHDHALMI VFLISALVLY VIITTVSTKL TNMYILDSQE 

        70         80         90        100        110        120 
IEIVWTVLPA LILILIALPS LRILYLMDEI NDPHLTIKAM GHQWYWSYEY TDYENLSFDS 

       130        140        150        160        170        180 
YMIPTQDLTP GQFRLLETDH RMVVPMESPI RILVSAEDVL HSWALPAMGV KMDAVPGRLN 

       190        200        210        220        230 
QTAFIASRPG VFYGQCSEIC GANHSFMPIV VEAVPLSHFE NWSTLMLKDA 

« Hide

References

[1]"The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome: conservation and variations among vertebrates."
Tzeng C.-S., Hui C.-F., Shen S.-C., Huang P.C.
Nucleic Acids Res. 20:4853-4858(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91245 Genomic DNA. Translation: AAB96814.1.
PIRS35465.
RefSeqNP_008306.1. NC_001727.1.

3D structure databases

ProteinModelPortalP34189.
SMRP34189. Positions 1-227.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID807990.

Organism-specific databases

CTD4513.

Phylogenomic databases

HOVERGENHBG012727.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_FORLA
AccessionPrimary (citable) accession number: P34189
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families