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P34188

- COX1_FORLA

UniProt

P34188 - COX1_FORLA

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Protein
Cytochrome c oxidase subunit 1
Gene
mt-co1, coi, coxi, mtco1
Organism
Formosania lacustris (Oriental stream loach) (Crossostoma lacustre)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi240 – 2401Copper B Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt-co1
Synonyms:coi, coxi, mtco1
Encoded oniMitochondrion
OrganismiFormosania lacustris (Oriental stream loach) (Crossostoma lacustre)
Taxonomic identifieri7980 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesBalitoridaeFormosania

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei56 – 7621Helical; Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei338 – 35821Helical; Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Cytochrome c oxidase subunit 1
PRO_0000183318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP34188.
SMRiP34188. Positions 3-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003841.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34188-1 [UniParc]FASTAAdd to Basket

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MAITRWFFST NHKDIGTLYL VFGAWAGMVG TALSLLIRAE LNQPGALLGD    50
DQIYNVIVTA HAFVMIFFMV MPILIGGFGN WLVPLMIGAP HMAFPRMNNM 100
SFWLLPPSFL LLLASSGVEA GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL 150
HLAGVSSILG AINFITTTIN MKPPALSQYQ TPLFVWAVLI TAVLLLLSLP 200
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGIISHVVAY YAGKKEPFGY MGMVWAMMAI GLLGFIVWAH HMFTVGMDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGG TIKWDTPMLW ALGFIFLFTV 350
GGLTGIVLSN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFVHWFPLF 400
TGFSLHDTWT KIHFGVMFIG VNLTFFPQHF LGLAGMPRRY SDYPDAYTLW 450
NTVSSIGSLI SLVAVIIFLF ILWEAFASKR QVMSVELTMT NVEWLHGCPP 500
PYHTFEEPAF VQVRSN 516
Length:516
Mass (Da):56,953
Last modified:February 1, 1994 - v1
Checksum:iE5DBD18C495E9167
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91245 Genomic DNA. Translation: AAB96813.1.
PIRiS35464.
RefSeqiNP_008305.1. NC_001727.1.

Genome annotation databases

GeneIDi807987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91245 Genomic DNA. Translation: AAB96813.1 .
PIRi S35464.
RefSeqi NP_008305.1. NC_001727.1.

3D structure databases

ProteinModelPortali P34188.
SMRi P34188. Positions 3-514.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 807987.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

HOVERGENi HBG003841.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome: conservation and variations among vertebrates."
    Tzeng C.-S., Hui C.-F., Shen S.-C., Huang P.C.
    Nucleic Acids Res. 20:4853-4858(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Oocyte.

Entry informationi

Entry nameiCOX1_FORLA
AccessioniPrimary (citable) accession number: P34188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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