##gff-version 3
P34184	UniProtKB	Chain	1	706	.	.	.	ID=PRO_0000145140;Note=DNA topoisomerase 1	
P34184	UniProtKB	Domain	1	140	.	.	.	Note=Toprim;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995	
P34184	UniProtKB	Domain	157	596	.	.	.	Note=Topo IA-type catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01383	
P34184	UniProtKB	Region	199	204	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000250;evidence=ECO:0000250	
P34184	UniProtKB	Active site	323	323	.	.	.	Note=O-(5'-phospho-DNA)-tyrosine intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01383	
P34184	UniProtKB	Site	48	48	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995	
P34184	UniProtKB	Site	167	167	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995	
P34184	UniProtKB	Site	171	171	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995	
P34184	UniProtKB	Site	325	325	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995	
P34184	UniProtKB	Site	529	529	.	.	.	Note=Interaction with DNA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00995	
P34184	UniProtKB	Sequence conflict	126	126	.	.	.	Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	142	142	.	.	.	Note=T->F;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	218	218	.	.	.	Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	254	254	.	.	.	Note=K->T;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	258	258	.	.	.	Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	352	352	.	.	.	Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	443	443	.	.	.	Note=W->R;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	523	524	.	.	.	Note=IT->TH;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P34184	UniProtKB	Sequence conflict	548	548	.	.	.	Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305