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Protein

Pheromone-binding protein

Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This major soluble protein in olfactory sensilla of male moths serves to solubilize the extremely hydrophobic pheromone molecules such as bombykol and to transport pheromone through the aqueous lymph to receptors located on olfactory cilia.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Pheromone response, Transport

Keywords - Ligandi

Pheromone-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-binding protein
Short name:
PBP
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
Proteomesi
  • UP000005204 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 164142Pheromone-binding proteinPRO_0000012559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 76
Disulfide bondi72 ↔ 130
Disulfide bondi119 ↔ 139

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Antenna.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi7091.BGIBMGA012615-TA.

Structurei

Secondary structure

1
164
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi24 – 3512Combined sources
Helixi38 – 447Combined sources
Helixi51 – 566Combined sources
Turni57 – 593Combined sources
Beta strandi60 – 623Combined sources
Helixi68 – 8013Combined sources
Helixi81 – 833Combined sources
Beta strandi88 – 903Combined sources
Helixi92 – 10110Combined sources
Helixi106 – 12217Combined sources
Helixi129 – 14618Combined sources
Beta strandi147 – 1493Combined sources
Helixi153 – 16311Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DQEX-ray1.80A/B23-159[»]
1GM0NMR-A23-164[»]
1LS8NMR-A23-164[»]
1XFRNMR-A23-150[»]
2FJYX-ray2.30A/B23-164[»]
2P70X-ray2.10A23-154[»]
2P71X-ray2.01A23-154[»]
ProteinModelPortaliP34174.
SMRiP34174. Positions 23-164.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34174.

Family & Domainsi

Sequence similaritiesi

Belongs to the PBP/GOBP family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.238.20. 1 hit.
InterProiIPR006072. Odorant/phero-bd_Lep.
IPR006170. PBP_GOBP.
[Graphical view]
PfamiPF01395. PBP_GOBP. 1 hit.
[Graphical view]
PIRSFiPIRSF015604. Odorant/phero_bd. 1 hit.
PRINTSiPR00484. PBPGOBP.
SMARTiSM00708. PhBP. 1 hit.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIQGQIALA LMVNMAVGSV DASQEVMKNL SLNFGKALDE CKKEMTLTDA
60 70 80 90 100
INEDFYNFWK EGYEIKNRET GCAIMCLSTK LNMLDPEGNL HHGNAMEFAK
110 120 130 140 150
KHGADETMAQ QLIDIVHGCE KSTPANDDKC IWTLGVATCF KAEIHKLNWA
160
PSMDVAVGEI LAEV
Length:164
Mass (Da):18,086
Last modified:November 1, 1997 - v2
Checksum:i57591C4C98C0F553
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94987 mRNA. Translation: CAA64443.1.
RefSeqiNP_001037494.1. NM_001044029.1.
UniGeneiBmo.15.

Genome annotation databases

GeneIDi693050.
KEGGibmor:693050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94987 mRNA. Translation: CAA64443.1.
RefSeqiNP_001037494.1. NM_001044029.1.
UniGeneiBmo.15.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DQEX-ray1.80A/B23-159[»]
1GM0NMR-A23-164[»]
1LS8NMR-A23-164[»]
1XFRNMR-A23-150[»]
2FJYX-ray2.30A/B23-164[»]
2P70X-ray2.10A23-154[»]
2P71X-ray2.01A23-154[»]
ProteinModelPortaliP34174.
SMRiP34174. Positions 23-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7091.BGIBMGA012615-TA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi693050.
KEGGibmor:693050.

Organism-specific databases

CTDi693050.

Miscellaneous databases

EvolutionaryTraceiP34174.

Family and domain databases

Gene3Di1.10.238.20. 1 hit.
InterProiIPR006072. Odorant/phero-bd_Lep.
IPR006170. PBP_GOBP.
[Graphical view]
PfamiPF01395. PBP_GOBP. 1 hit.
[Graphical view]
PIRSFiPIRSF015604. Odorant/phero_bd. 1 hit.
PRINTSiPR00484. PBPGOBP.
SMARTiSM00708. PhBP. 1 hit.
[Graphical view]
SUPFAMiSSF47565. SSF47565. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Antenna.
  2. "Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects."
    Vogt R.G., Prestwich G.D., Lerner M.R.
    J. Neurobiol. 22:74-84(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-57.
  3. "Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex."
    Sandler B.H., Nikonova L., Leal W.S., Clardy J.
    Chem. Biol. 7:143-151(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Entry informationi

Entry nameiPBP_BOMMO
AccessioniPrimary (citable) accession number: P34174
Secondary accession number(s): Q17235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1997
Last modified: October 14, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.