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Protein

Mating hormone A-factor 2

Gene

MFA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.

GO - Molecular functioni

  • mating pheromone activity Source: SGD

GO - Biological processi

  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD

Keywordsi

Molecular functionPheromone

Enzyme and pathway databases

BioCyciYEAST:G3O-33163-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mating hormone A-factor 2
Gene namesi
Name:MFA2
Ordered Locus Names:YNL145W
ORF Names:N1204, N1787
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL145W.
SGDiS000005089. MFA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000216931 – 231 PublicationAdd BLAST23
PeptideiPRO_000002169424 – 35Mating hormone A-factor 2Add BLAST12
PropeptideiPRO_000002169536 – 38Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35Cysteine methyl ester1 Publication1
Lipidationi35S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP34166.
TopDownProteomicsiP34166.

Interactioni

GO - Molecular functioni

  • mating pheromone activity Source: SGD

Protein-protein interaction databases

BioGridi35683. 88 interactors.
DIPiDIP-2140N.
IntActiP34166. 2 interactors.
MINTiMINT-527449.
STRINGi4932.YNL145W.

Structurei

3D structure databases

ProteinModelPortaliP34166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00860000135619.
InParanoidiP34166.
KOiK11235.
OrthoDBiEOG092C5ZYC.

Family and domain databases

InterProiView protein in InterPro
IPR035296. Mfa1/2.
PfamiView protein in Pfam
PF17317. MFA1_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026230. PD026230. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MQPITTASTQ ATQKDKSSEK KDNYIIKGLF WDPACVIA
Length:38
Mass (Da):4,229
Last modified:February 1, 1994 - v1
Checksum:iC71466AEA2F133C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20823 Genomic DNA. Translation: AAA68602.1.
U26204 Genomic DNA. Translation: AAA67688.1.
Z46843 Genomic DNA. Translation: CAA86881.1.
S48033 mRNA. Translation: AAD13854.1.
Z71421 Genomic DNA. Translation: CAA96028.1.
AY693189 Genomic DNA. Translation: AAT93208.1.
BK006947 Genomic DNA. Translation: DAA10404.1.
PIRiS55139.
RefSeqiNP_014254.1. NM_001182983.1.

Genome annotation databases

EnsemblFungiiYNL145W; YNL145W; YNL145W.
GeneIDi855577.
KEGGisce:YNL145W.

Similar proteinsi

Entry informationi

Entry nameiMFA2_YEAST
AccessioniPrimary (citable) accession number: P34166
Secondary accession number(s): D6W138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 27, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names