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Protein

Mating hormone A-factor 1

Gene

MFA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.

Miscellaneous

Present with 28900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mating pheromone activity Source: SGD

GO - Biological processi

  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD

Keywordsi

Molecular functionPheromone

Enzyme and pathway databases

BioCyciYEAST:G3O-29989-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mating hormone A-factor 1
Gene namesi
Name:MFA1
Ordered Locus Names:YDR461W
ORF Names:D8035.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR461W.
SGDiS000002869. MFA1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000216901 – 211 PublicationAdd BLAST21
PeptideiPRO_000002169122 – 33Mating hormone A-factor 1Add BLAST12
PropeptideiPRO_000002169234 – 36Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33Cysteine methyl ester1 Publication1
Lipidationi33S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP34165.

Miscellaneous databases

PMAP-CutDBiP34165.

Interactioni

GO - Molecular functioni

  • mating pheromone activity Source: SGD

Protein-protein interaction databases

BioGridi32515. 11 interactors.
DIPiDIP-4646N.
IntActiP34165. 1 interactor.
MINTiMINT-567416.
STRINGi4932.YDR461W.

Structurei

3D structure databases

ProteinModelPortaliP34165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00860000135619.
InParanoidiP34165.
KOiK11235.
OrthoDBiEOG092C5ZYC.

Family and domain databases

InterProiView protein in InterPro
IPR035296. Mfa1/2.
PfamiView protein in Pfam
PF17317. MFA1_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026230. PD026230. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MQPSTATAAP KEKTSSEKKD NYIIKGVFWD PACVIA
Length:36
Mass (Da):3,927
Last modified:February 1, 1994 - v1
Checksum:i03E051D7D6C2522F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20817 Genomic DNA. Translation: AAA68601.1.
U26203 Genomic DNA. Translation: AAA67687.1.
U33050 Genomic DNA. Translation: AAB64920.1.
AY557797 Genomic DNA. Translation: AAS56123.1.
BK006938 Genomic DNA. Translation: DAA12295.1.
PIRiS59735.
RefSeqiNP_010749.3. NM_001180769.3.

Genome annotation databases

EnsemblFungiiYDR461W; YDR461W; YDR461W.
GeneIDi852072.
KEGGisce:YDR461W.

Similar proteinsi

Entry informationi

Entry nameiMFA1_YEAST
AccessioniPrimary (citable) accession number: P34165
Secondary accession number(s): D6VT85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 22, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names