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Protein

Mating hormone A-factor 1

Gene

MFA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.

GO - Molecular functioni

  • mating pheromone activity Source: SGD

GO - Biological processi

  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Pheromone

Enzyme and pathway databases

BioCyciYEAST:G3O-29989-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mating hormone A-factor 1
Gene namesi
Name:MFA1
Ordered Locus Names:YDR461W
ORF Names:D8035.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR461W.
SGDiS000002869. MFA1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000216901 – 211 PublicationAdd BLAST21
PeptideiPRO_000002169122 – 33Mating hormone A-factor 1Add BLAST12
PropeptideiPRO_000002169234 – 36Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33Cysteine methyl ester1 Publication1
Lipidationi33S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP34165.

Miscellaneous databases

PMAP-CutDBP34165.

Interactioni

GO - Molecular functioni

  • mating pheromone activity Source: SGD

Protein-protein interaction databases

BioGridi32515. 8 interactors.
DIPiDIP-4646N.
MINTiMINT-567416.

Structurei

3D structure databases

ProteinModelPortaliP34165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00860000135619.
InParanoidiP34165.
KOiK11235.
OrthoDBiEOG092C5ZYC.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MQPSTATAAP KEKTSSEKKD NYIIKGVFWD PACVIA
Length:36
Mass (Da):3,927
Last modified:February 1, 1994 - v1
Checksum:i03E051D7D6C2522F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20817 Genomic DNA. Translation: AAA68601.1.
U26203 Genomic DNA. Translation: AAA67687.1.
U33050 Genomic DNA. Translation: AAB64920.1.
AY557797 Genomic DNA. Translation: AAS56123.1.
BK006938 Genomic DNA. Translation: DAA12295.1.
PIRiS59735.
RefSeqiNP_010749.3. NM_001180769.3.

Genome annotation databases

EnsemblFungiiYDR461W; YDR461W; YDR461W.
GeneIDi852072.
KEGGisce:YDR461W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20817 Genomic DNA. Translation: AAA68601.1.
U26203 Genomic DNA. Translation: AAA67687.1.
U33050 Genomic DNA. Translation: AAB64920.1.
AY557797 Genomic DNA. Translation: AAS56123.1.
BK006938 Genomic DNA. Translation: DAA12295.1.
PIRiS59735.
RefSeqiNP_010749.3. NM_001180769.3.

3D structure databases

ProteinModelPortaliP34165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32515. 8 interactors.
DIPiDIP-4646N.
MINTiMINT-567416.

Proteomic databases

PRIDEiP34165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR461W; YDR461W; YDR461W.
GeneIDi852072.
KEGGisce:YDR461W.

Organism-specific databases

EuPathDBiFungiDB:YDR461W.
SGDiS000002869. MFA1.

Phylogenomic databases

GeneTreeiENSGT00860000135619.
InParanoidiP34165.
KOiK11235.
OrthoDBiEOG092C5ZYC.

Enzyme and pathway databases

BioCyciYEAST:G3O-29989-MONOMER.

Miscellaneous databases

PMAP-CutDBP34165.
PROiP34165.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMFA1_YEAST
AccessioniPrimary (citable) accession number: P34165
Secondary accession number(s): D6VT85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 28900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.