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P34161

- YOX1_YEAST

UniProt

P34161 - YOX1_YEAST

Protein

Homeobox protein YOX1

Gene

YOX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during the interval from late G1 to M phases. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. In vitro, is capable of binding to the DNA of the leucine tRNA gene.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi176 – 23560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: SGD
    2. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: SGD
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Cell cycle, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32629-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein YOX1
    Gene namesi
    Name:YOX1
    Ordered Locus Names:YML027W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML027w.
    SGDiS000004489. YOX1.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: SGD
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Homeobox protein YOX1PRO_0000049387Add
    BLAST

    Proteomic databases

    MaxQBiP34161.
    PaxDbiP34161.

    Expressioni

    Developmental stagei

    Expressed from late G1 phase.1 Publication

    Inductioni

    Transcriptionally activated by SWI4-SWI6 heterodimer.

    Gene expression databases

    GenevestigatoriP34161.

    Interactioni

    Subunit structurei

    Interacts with MCM1.1 Publication

    Protein-protein interaction databases

    BioGridi35142. 29 interactions.
    DIPiDIP-4566N.
    IntActiP34161. 8 interactions.
    MINTiMINT-557333.
    STRINGi4932.YML027W.

    Structurei

    3D structure databases

    ProteinModelPortaliP34161.
    SMRiP34161. Positions 175-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiCOG5576.
    GeneTreeiENSGT00530000068906.
    HOGENOMiHOG000000747.
    KOiK12411.
    OrthoDBiEOG7KM64C.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34161-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQETKMLPS LSSLLSGTEI SSSPVSPSFT NPRTSFHLDD RGTIKLPPLN    50
    TSINRPRSVE SALRHTVTSL HENSSAYGDD MLKHTQSDSA LSSQLNSSQE 100
    TVDESHENLL LTPLNSKKRD YSVSSKKNDI LTPLSAAKSI IIPSASKEKR 150
    RAFAFITHSQ ETFPKKEPKI DNAPLARRKR RRTSSQELSI LQAEFEKCPA 200
    PSKEKRIELA ESCHMTEKAV QIWFQNKRQA VKRQRIATSK STTIIQTVSP 250
    PSPPLDVHAT PLASRVKADI LRDGSSCSRS SSSSPLENTP PRPHHSLNRR 300
    SSTPSIKRSQ ALTFHLNPQK KTLTPVKTSP NSRVNKLINS IDHSPSKAKR 350
    PVSNPSGSPK RKRKFGFKIV DQQPLKDLDP NAFRG 385
    Length:385
    Mass (Da):42,739
    Last modified:October 1, 1996 - v2
    Checksum:iF21A295CDD97A282
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti291 – 2966PRPHHS → QGLIIP(PubMed:9169872)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46659 Genomic DNA. Translation: CAA86628.1.
    AY693100 Genomic DNA. Translation: AAT93119.1.
    X62392 Genomic DNA. Translation: CAA44264.1.
    BK006946 Genomic DNA. Translation: DAA09871.1.
    PIRiS49752.
    RefSeqiNP_013685.1. NM_001182385.1.

    Genome annotation databases

    EnsemblFungiiYML027W; YML027W; YML027W.
    GeneIDi854981.
    KEGGisce:YML027W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46659 Genomic DNA. Translation: CAA86628.1 .
    AY693100 Genomic DNA. Translation: AAT93119.1 .
    X62392 Genomic DNA. Translation: CAA44264.1 .
    BK006946 Genomic DNA. Translation: DAA09871.1 .
    PIRi S49752.
    RefSeqi NP_013685.1. NM_001182385.1.

    3D structure databases

    ProteinModelPortali P34161.
    SMRi P34161. Positions 175-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35142. 29 interactions.
    DIPi DIP-4566N.
    IntActi P34161. 8 interactions.
    MINTi MINT-557333.
    STRINGi 4932.YML027W.

    Proteomic databases

    MaxQBi P34161.
    PaxDbi P34161.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML027W ; YML027W ; YML027W .
    GeneIDi 854981.
    KEGGi sce:YML027W.

    Organism-specific databases

    CYGDi YML027w.
    SGDi S000004489. YOX1.

    Phylogenomic databases

    eggNOGi COG5576.
    GeneTreei ENSGT00530000068906.
    HOGENOMi HOG000000747.
    KOi K12411.
    OrthoDBi EOG7KM64C.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32629-MONOMER.

    Miscellaneous databases

    NextBioi 978100.

    Gene expression databases

    Genevestigatori P34161.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "In vitro binding to the leucine tRNA gene identifies a novel yeast homeobox gene."
      Kaufmann E.
      Chromosoma 102:174-179(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-296.
    5. "Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle."
      Pramila T., Miles S., GuhaThakurta D., Jemiolo D., Breeden L.L.
      Genes Dev. 16:3034-3045(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING, DEVELOPMENTAL STAGE, INTERACTION WITH MCM1.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYOX1_YEAST
    AccessioniPrimary (citable) accession number: P34161
    Secondary accession number(s): D6VZE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 861 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3