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P34161 (YOX1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein YOX1
Gene names
Name:YOX1
Ordered Locus Names:YML027W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during the interval from late G1 to M phases. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. In vitro, is capable of binding to the DNA of the leucine tRNA gene. Ref.5

Subunit structure

Interacts with MCM1. Ref.5

Subcellular location

Nucleus.

Developmental stage

Expressed from late G1 phase. Ref.5

Induction

Transcriptionally activated by SWI4-SWI6 heterodimer.

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385Homeobox protein YOX1
PRO_0000049387

Regions

DNA binding176 – 23560Homeobox Ref.5

Experimental info

Sequence conflict291 – 2966PRPHHS → QGLIIP Ref.1

Sequences

Sequence LengthMass (Da)Tools
P34161 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: F21A295CDD97A282

FASTA38542,739
        10         20         30         40         50         60 
MSQETKMLPS LSSLLSGTEI SSSPVSPSFT NPRTSFHLDD RGTIKLPPLN TSINRPRSVE 

        70         80         90        100        110        120 
SALRHTVTSL HENSSAYGDD MLKHTQSDSA LSSQLNSSQE TVDESHENLL LTPLNSKKRD 

       130        140        150        160        170        180 
YSVSSKKNDI LTPLSAAKSI IIPSASKEKR RAFAFITHSQ ETFPKKEPKI DNAPLARRKR 

       190        200        210        220        230        240 
RRTSSQELSI LQAEFEKCPA PSKEKRIELA ESCHMTEKAV QIWFQNKRQA VKRQRIATSK 

       250        260        270        280        290        300 
STTIIQTVSP PSPPLDVHAT PLASRVKADI LRDGSSCSRS SSSSPLENTP PRPHHSLNRR 

       310        320        330        340        350        360 
SSTPSIKRSQ ALTFHLNPQK KTLTPVKTSP NSRVNKLINS IDHSPSKAKR PVSNPSGSPK 

       370        380 
RKRKFGFKIV DQQPLKDLDP NAFRG 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"In vitro binding to the leucine tRNA gene identifies a novel yeast homeobox gene."
Kaufmann E.
Chromosoma 102:174-179(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-296.
[5]"Conserved homeodomain proteins interact with MADS box protein Mcm1 to restrict ECB-dependent transcription to the M/G1 phase of the cell cycle."
Pramila T., Miles S., GuhaThakurta D., Jemiolo D., Breeden L.L.
Genes Dev. 16:3034-3045(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING, DEVELOPMENTAL STAGE, INTERACTION WITH MCM1.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z46659 Genomic DNA. Translation: CAA86628.1.
AY693100 Genomic DNA. Translation: AAT93119.1.
X62392 Genomic DNA. Translation: CAA44264.1.
BK006946 Genomic DNA. Translation: DAA09871.1.
PIRS49752.
RefSeqNP_013685.1. NM_001182385.1.

3D structure databases

ProteinModelPortalP34161.
SMRP34161. Positions 175-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35142. 29 interactions.
DIPDIP-4566N.
IntActP34161. 8 interactions.
MINTMINT-557333.
STRING4932.YML027W.

Proteomic databases

MaxQBP34161.
PaxDbP34161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYML027W; YML027W; YML027W.
GeneID854981.
KEGGsce:YML027W.

Organism-specific databases

CYGDYML027w.
SGDS000004489. YOX1.

Phylogenomic databases

eggNOGCOG5576.
GeneTreeENSGT00530000068906.
HOGENOMHOG000000747.
KOK12411.
OrthoDBEOG7KM64C.

Enzyme and pathway databases

BioCycYEAST:G3O-32629-MONOMER.

Gene expression databases

GenevestigatorP34161.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978100.

Entry information

Entry nameYOX1_YEAST
AccessionPrimary (citable) accession number: P34161
Secondary accession number(s): D6VZE7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families