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P34138

- PTP2_DICDI

UniProt

P34138 - PTP2_DICDI

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Protein
Tyrosine-protein phosphatase 2
Gene
ptpB, ptp2, DDB_G0277865
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei281 – 2811Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. phosphatase activity Source: dictyBase
  2. protein tyrosine phosphatase activity Source: dictyBase

GO - Biological processi

  1. aggregation involved in sorocarp development Source: dictyBase
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 2 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase 2
Short name:
PTPA
Gene namesi
Name:ptpB
Synonyms:ptp2
ORF Names:DDB_G0277865
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277865. ptpB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Tyrosine-protein phosphatase 2
PRO_0000094887Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP34138.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 347321Tyrosine-protein phosphatase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 869Poly-Asp
Compositional biasi95 – 1039Poly-Asn

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5599.
KOiK01104.
OMAiEMRNERP.
PhylomeDBiP34138.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34138-1 [UniParc]FASTAAdd to Basket

« Hide

MDESFDAFEI KPNSSIIEHF NNHPTCIDKE FNFILQKTEL RALETDKFRS    50
ALEAKNKLKN RYSNVLPFEE TRVKINIDDD DDDEDDNEDD IIVSNNNNNN 100
NNNEKRIKRN SIGSSGQSDV MSNSSDEEDH GGSGDEGTTL SDYINASFIN 150
NGTYICTQGP LLNTIVDFWK MIWEQNSNII VMLTREEENF KTKCDKYWPD 200
KDEERYGNFI VKFDNNITIP DILIRREFTL ENLKDNKTRK IYHFQYTTWP 250
DHGTPVSTTG FLKFVSFVDH EKRSGPIVVH CSAGIGRSGT FVAIHSIVAK 300
FAKHYDEKKQ APSINLPKLV VEMRNERPGM VQTRDQYRFC YLAISEAMNT 350
VLKKEQKKRK GLSYSYSSIP LTGPEHD 377
Length:377
Mass (Da):43,488
Last modified:February 1, 1994 - v1
Checksum:i5B08F6EB54829FD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15420 mRNA. Translation: AAA33242.1.
AAFI02000023 Genomic DNA. Translation: EAL68105.1.
PIRiA48711.
RefSeqiXP_642173.1. XM_637081.1.

Genome annotation databases

EnsemblProtistsiDDB0214985; DDB0214985; DDB_G0277865.
GeneIDi8621380.
KEGGiddi:DDB_G0277865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15420 mRNA. Translation: AAA33242.1 .
AAFI02000023 Genomic DNA. Translation: EAL68105.1 .
PIRi A48711.
RefSeqi XP_642173.1. XM_637081.1.

3D structure databases

ProteinModelPortali P34138.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0214985 ; DDB0214985 ; DDB_G0277865 .
GeneIDi 8621380.
KEGGi ddi:DDB_G0277865.

Organism-specific databases

dictyBasei DDB_G0277865. ptpB.

Phylogenomic databases

eggNOGi COG5599.
KOi K01104.
OMAi EMRNERP.
PhylomeDBi P34138.

Family and domain databases

Gene3Di 3.90.190.10. 2 hits.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of a Dictyostelium discoideum protein tyrosine phosphatase."
    Ramalingam R., Shaw D.R., Ennis H.
    J. Biol. Chem. 268:22680-22685(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPTP2_DICDI
AccessioniPrimary (citable) accession number: P34138
Secondary accession number(s): Q54YM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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