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P34138 (PTP2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 2

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase 2
Short name=PTPA
Gene names
Name:ptpB
Synonyms:ptp2
ORF Names:DDB_G0277865
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Tyrosine-protein phosphatase 2
PRO_0000094887

Regions

Domain27 – 347321Tyrosine-protein phosphatase
Compositional bias78 – 869Poly-Asp
Compositional bias95 – 1039Poly-Asn

Sites

Active site2811Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P34138 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 5B08F6EB54829FD9

FASTA37743,488
        10         20         30         40         50         60 
MDESFDAFEI KPNSSIIEHF NNHPTCIDKE FNFILQKTEL RALETDKFRS ALEAKNKLKN 

        70         80         90        100        110        120 
RYSNVLPFEE TRVKINIDDD DDDEDDNEDD IIVSNNNNNN NNNEKRIKRN SIGSSGQSDV 

       130        140        150        160        170        180 
MSNSSDEEDH GGSGDEGTTL SDYINASFIN NGTYICTQGP LLNTIVDFWK MIWEQNSNII 

       190        200        210        220        230        240 
VMLTREEENF KTKCDKYWPD KDEERYGNFI VKFDNNITIP DILIRREFTL ENLKDNKTRK 

       250        260        270        280        290        300 
IYHFQYTTWP DHGTPVSTTG FLKFVSFVDH EKRSGPIVVH CSAGIGRSGT FVAIHSIVAK 

       310        320        330        340        350        360 
FAKHYDEKKQ APSINLPKLV VEMRNERPGM VQTRDQYRFC YLAISEAMNT VLKKEQKKRK 

       370 
GLSYSYSSIP LTGPEHD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression of a Dictyostelium discoideum protein tyrosine phosphatase."
Ramalingam R., Shaw D.R., Ennis H.
J. Biol. Chem. 268:22680-22685(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L15420 mRNA. Translation: AAA33242.1.
AAFI02000023 Genomic DNA. Translation: EAL68105.1.
PIRA48711.
RefSeqXP_642173.1. XM_637081.1.

3D structure databases

ProteinModelPortalP34138.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0214985; DDB0214985; DDB_G0277865.
GeneID8621380.
KEGGddi:DDB_G0277865.

Organism-specific databases

dictyBaseDDB_G0277865. ptpB.

Phylogenomic databases

eggNOGCOG5599.
OMAEMRNERP.
PhylomeDBP34138.

Family and domain databases

Gene3D3.90.190.10. 2 hits.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 2 hits.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTP2_DICDI
AccessionPrimary (citable) accession number: P34138
Secondary accession number(s): Q54YM9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase