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P34138

- PTP2_DICDI

UniProt

P34138 - PTP2_DICDI

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Protein

Tyrosine-protein phosphatase 2

Gene

ptpB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei281 – 2811Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. phosphatase activity Source: dictyBase
  2. protein tyrosine phosphatase activity Source: dictyBase

GO - Biological processi

  1. aggregation involved in sorocarp development Source: dictyBase
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 2 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase 2
Short name:
PTPA
Gene namesi
Name:ptpB
Synonyms:ptp2
ORF Names:DDB_G0277865
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277865. ptpB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Tyrosine-protein phosphatase 2PRO_0000094887Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP34138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 347321Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 869Poly-Asp
Compositional biasi95 – 1039Poly-Asn

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
InParanoidiP34138.
KOiK01104.
OMAiEMRNERP.
PhylomeDBiP34138.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34138-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDESFDAFEI KPNSSIIEHF NNHPTCIDKE FNFILQKTEL RALETDKFRS
60 70 80 90 100
ALEAKNKLKN RYSNVLPFEE TRVKINIDDD DDDEDDNEDD IIVSNNNNNN
110 120 130 140 150
NNNEKRIKRN SIGSSGQSDV MSNSSDEEDH GGSGDEGTTL SDYINASFIN
160 170 180 190 200
NGTYICTQGP LLNTIVDFWK MIWEQNSNII VMLTREEENF KTKCDKYWPD
210 220 230 240 250
KDEERYGNFI VKFDNNITIP DILIRREFTL ENLKDNKTRK IYHFQYTTWP
260 270 280 290 300
DHGTPVSTTG FLKFVSFVDH EKRSGPIVVH CSAGIGRSGT FVAIHSIVAK
310 320 330 340 350
FAKHYDEKKQ APSINLPKLV VEMRNERPGM VQTRDQYRFC YLAISEAMNT
360 370
VLKKEQKKRK GLSYSYSSIP LTGPEHD
Length:377
Mass (Da):43,488
Last modified:February 1, 1994 - v1
Checksum:i5B08F6EB54829FD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15420 mRNA. Translation: AAA33242.1.
AAFI02000023 Genomic DNA. Translation: EAL68105.1.
PIRiA48711.
RefSeqiXP_642173.1. XM_637081.1.

Genome annotation databases

EnsemblProtistsiDDB0214985; DDB0214985; DDB_G0277865.
GeneIDi8621380.
KEGGiddi:DDB_G0277865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L15420 mRNA. Translation: AAA33242.1 .
AAFI02000023 Genomic DNA. Translation: EAL68105.1 .
PIRi A48711.
RefSeqi XP_642173.1. XM_637081.1.

3D structure databases

ProteinModelPortali P34138.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0214985 ; DDB0214985 ; DDB_G0277865 .
GeneIDi 8621380.
KEGGi ddi:DDB_G0277865.

Organism-specific databases

dictyBasei DDB_G0277865. ptpB.

Phylogenomic databases

eggNOGi COG5599.
InParanoidi P34138.
KOi K01104.
OMAi EMRNERP.
PhylomeDBi P34138.

Family and domain databases

Gene3Di 3.90.190.10. 2 hits.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of a Dictyostelium discoideum protein tyrosine phosphatase."
    Ramalingam R., Shaw D.R., Ennis H.
    J. Biol. Chem. 268:22680-22685(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPTP2_DICDI
AccessioniPrimary (citable) accession number: P34138
Secondary accession number(s): Q54YM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3