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P34137

- PTP1_DICDI

UniProt

P34137 - PTP1_DICDI

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Protein
Tyrosine-protein phosphatase 1
Gene
ptpA1-1, ptp1, DDB_G0273097
ptpA1-2, ptp1, DDB_G0273817
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May have a role in growth and in the early stages of development. Affects the timing of development.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei310 – 3101Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Organism-specific databases

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine-phosphate phosphohydrolase 1
    Gene namesi
    Name:ptpA1-1
    Synonyms:ptp1
    ORF Names:DDB_G0273097
    AND
    Name:ptpA1-2
    Synonyms:ptp1
    ORF Names:DDB_G0273817
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence
    dictyBaseiDDB_G0273097. ptpA1-1.
    DDB_G0273817. ptpA1-2.

    Subcellular locationi

    Cytoplasm. Cell membrane Inferred
    Note: Might be tethered to the plasma membrane.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Tyrosine-protein phosphatase 1
    PRO_0000094886Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed predominantly in anterior-like cells and to a lesser degree in prestalk cells.

    Developmental stagei

    Expressed at a very low level in vegetative cells, induced by 4 hours, maximally expressed at the tight aggregate stage and through the remainder of development.

    Structurei

    3D structure databases

    ProteinModelPortaliP34137.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 471375Tyrosine-protein phosphatase
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni327 – 426100PTPase insert (Asn-rich)
    Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 114114Ser-rich
    Add
    BLAST
    Compositional biasi382 – 40019Poly-Asn
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5599.
    OMAiENCRIKC.
    PhylomeDBiP34137.

    Family and domain databases

    Gene3Di3.90.190.10. 2 hits.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34137-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSVESSNQM NGSIENKTNK IDISVLRPLP TRSNSSISLS SSSHSSFSRM    50
    GSLGSLPTNS GSSSPYYNNS SFDLVDEERI KSSIYNLKNH IKCIHKIKEE 100
    FRLLEESVGP SETSEGDKKH NTSKNRYTNI LPVNHTRVQL KKIQDKEGSD 150
    YINANYIDGA YPKQFICTQG PLPNTIADFW RMVWENRCRI IVMLSRESEN 200
    CRIKCDRYWP EQIGGEQFSI YGNGNEVFGT YSVELVEVIQ DPEREIITRN 250
    IRLTFEGETR DITQYQYEGW PDHNIPDHTQ PFRQLLHSIT NRQNQIIPSS 300
    DRNVPIIVHC SAGVGRTGTF CTAVIMMKKL DHYFKQLDAT PIDQVVDPFT 350
    HLPITEYQSD NLDLKGLGYH FKSSIYNSNG INNNNNNNLN NNNNINNNSN 400
    GSNNTPQTEP NNEEDDDDAA ESDLKYAIMD KYNSRIDFNL FSIVLKLREQ 450
    RPGMVQQLEQ YLFCYKTILD EIYHRLNCKL GFSLPHVNNI NNYNNYSNTT 500
    TTTTSSLAST TIIHPSTNSK LN 522
    Length:522
    Mass (Da):59,554
    Last modified:December 4, 2007 - v2
    Checksum:iEFCC04A0F6AEB8BF
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti423 – 4242DL → T in AAA33241. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07125 Genomic DNA. Translation: AAA33241.1.
    AAFI02000011 Genomic DNA. Translation: EAL70599.1.
    AAFI02000009 Genomic DNA. Translation: EAL70766.1.
    PIRiA44267.
    RefSeqiXP_644525.1. XM_639433.1.
    XP_644725.1. XM_639633.1.

    Genome annotation databases

    EnsemblProtistsiDDB0185117; DDB0185117; DDB_G0273097.
    DDB0238491; DDB0238491; DDB_G0273817.
    GeneIDi8618825.
    8619151.
    KEGGiddi:DDB_G0273097.
    ddi:DDB_G0273817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07125 Genomic DNA. Translation: AAA33241.1 .
    AAFI02000011 Genomic DNA. Translation: EAL70599.1 .
    AAFI02000009 Genomic DNA. Translation: EAL70766.1 .
    PIRi A44267.
    RefSeqi XP_644525.1. XM_639433.1.
    XP_644725.1. XM_639633.1.

    3D structure databases

    ProteinModelPortali P34137.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0185117 ; DDB0185117 ; DDB_G0273097 .
    DDB0238491 ; DDB0238491 ; DDB_G0273817 .
    GeneIDi 8618825.
    8619151.
    KEGGi ddi:DDB_G0273097.
    ddi:DDB_G0273817.

    Organism-specific databases

    dictyBasei DDB_G0273097. ptpA1-1.
    DDB_G0273817. ptpA1-2.

    Phylogenomic databases

    eggNOGi COG5599.
    OMAi ENCRIKC.
    PhylomeDBi P34137.

    Family and domain databases

    Gene3Di 3.90.190.10. 2 hits.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium."
      Howard P.K., Sefton B.M., Firtel R.A.
      Cell 71:637-647(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPTP1_DICDI
    AccessioniPrimary (citable) accession number: P34137
    Secondary accession number(s): Q556U4, Q86AJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: December 4, 2007
    Last modified: June 11, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The PTPase domain is interrupted by a PTPase insert which shares no homologies with other PTPase proteins.

    Caution

    The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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