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P34137

- PTP1_DICDI

UniProt

P34137 - PTP1_DICDI

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Protein

Tyrosine-protein phosphatase 1

Gene

ptpA1-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May have a role in growth and in the early stages of development. Affects the timing of development.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei310 – 3101Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase 1
Gene namesi
Name:ptpA1-1
Synonyms:ptp1
ORF Names:DDB_G0273097
AND
Name:ptpA1-2
Synonyms:ptp1
ORF Names:DDB_G0273817
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273097. ptpA1-1.
DDB_G0273817. ptpA1-2.

Subcellular locationi

Cytoplasm. Cell membrane Curated
Note: Might be tethered to the plasma membrane.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Tyrosine-protein phosphatase 1PRO_0000094886Add
BLAST

Expressioni

Tissue specificityi

Expressed predominantly in anterior-like cells and to a lesser degree in prestalk cells.

Developmental stagei

Expressed at a very low level in vegetative cells, induced by 4 hours, maximally expressed at the tight aggregate stage and through the remainder of development.

Structurei

3D structure databases

ProteinModelPortaliP34137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 471375Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni327 – 426100PTPase insert (Asn-rich)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 114114Ser-richAdd
BLAST
Compositional biasi382 – 40019Poly-AsnAdd
BLAST

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
InParanoidiP34137.
OMAiENCRIKC.
PhylomeDBiP34137.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34137-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSVESSNQM NGSIENKTNK IDISVLRPLP TRSNSSISLS SSSHSSFSRM
60 70 80 90 100
GSLGSLPTNS GSSSPYYNNS SFDLVDEERI KSSIYNLKNH IKCIHKIKEE
110 120 130 140 150
FRLLEESVGP SETSEGDKKH NTSKNRYTNI LPVNHTRVQL KKIQDKEGSD
160 170 180 190 200
YINANYIDGA YPKQFICTQG PLPNTIADFW RMVWENRCRI IVMLSRESEN
210 220 230 240 250
CRIKCDRYWP EQIGGEQFSI YGNGNEVFGT YSVELVEVIQ DPEREIITRN
260 270 280 290 300
IRLTFEGETR DITQYQYEGW PDHNIPDHTQ PFRQLLHSIT NRQNQIIPSS
310 320 330 340 350
DRNVPIIVHC SAGVGRTGTF CTAVIMMKKL DHYFKQLDAT PIDQVVDPFT
360 370 380 390 400
HLPITEYQSD NLDLKGLGYH FKSSIYNSNG INNNNNNNLN NNNNINNNSN
410 420 430 440 450
GSNNTPQTEP NNEEDDDDAA ESDLKYAIMD KYNSRIDFNL FSIVLKLREQ
460 470 480 490 500
RPGMVQQLEQ YLFCYKTILD EIYHRLNCKL GFSLPHVNNI NNYNNYSNTT
510 520
TTTTSSLAST TIIHPSTNSK LN
Length:522
Mass (Da):59,554
Last modified:December 4, 2007 - v2
Checksum:iEFCC04A0F6AEB8BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti423 – 4242DL → T in AAA33241. (PubMed:1423620)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07125 Genomic DNA. Translation: AAA33241.1.
AAFI02000011 Genomic DNA. Translation: EAL70599.1.
AAFI02000009 Genomic DNA. Translation: EAL70766.1.
PIRiA44267.
RefSeqiXP_644525.1. XM_639433.1.
XP_644725.1. XM_639633.1.

Genome annotation databases

EnsemblProtistsiDDB0185117; DDB0185117; DDB_G0273097.
DDB0238491; DDB0238491; DDB_G0273817.
GeneIDi8618825.
8619151.
KEGGiddi:DDB_G0273097.
ddi:DDB_G0273817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07125 Genomic DNA. Translation: AAA33241.1 .
AAFI02000011 Genomic DNA. Translation: EAL70599.1 .
AAFI02000009 Genomic DNA. Translation: EAL70766.1 .
PIRi A44267.
RefSeqi XP_644525.1. XM_639433.1.
XP_644725.1. XM_639633.1.

3D structure databases

ProteinModelPortali P34137.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0185117 ; DDB0185117 ; DDB_G0273097 .
DDB0238491 ; DDB0238491 ; DDB_G0273817 .
GeneIDi 8618825.
8619151.
KEGGi ddi:DDB_G0273097.
ddi:DDB_G0273817.

Organism-specific databases

dictyBasei DDB_G0273097. ptpA1-1.
DDB_G0273817. ptpA1-2.

Phylogenomic databases

eggNOGi COG5599.
InParanoidi P34137.
OMAi ENCRIKC.
PhylomeDBi P34137.

Family and domain databases

Gene3Di 3.90.190.10. 2 hits.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium."
    Howard P.K., Sefton B.M., Firtel R.A.
    Cell 71:637-647(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiPTP1_DICDI
AccessioniPrimary (citable) accession number: P34137
Secondary accession number(s): Q556U4, Q86AJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The PTPase domain is interrupted by a PTPase insert which shares no homologies with other PTPase proteins.

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3