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P34137 (PTP1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase 1

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine-phosphate phosphohydrolase 1
Gene names
Name:ptpA1-1
Synonyms:ptp1
ORF Names:DDB_G0273097
AND
Name:ptpA1-2
Synonyms:ptp1
ORF Names:DDB_G0273817
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in growth and in the early stages of development. Affects the timing of development.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm. Cell membrane Probable. Note: Might be tethered to the plasma membrane.

Tissue specificity

Expressed predominantly in anterior-like cells and to a lesser degree in prestalk cells.

Developmental stage

Expressed at a very low level in vegetative cells, induced by 4 hours, maximally expressed at the tight aggregate stage and through the remainder of development.

Miscellaneous

The PTPase domain is interrupted by a PTPase insert which shares no homologies with other PTPase proteins.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Membrane
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Tyrosine-protein phosphatase 1
PRO_0000094886

Regions

Domain97 – 471375Tyrosine-protein phosphatase
Region327 – 426100PTPase insert (Asn-rich)
Compositional bias1 – 114114Ser-rich
Compositional bias382 – 40019Poly-Asn

Sites

Active site3101Phosphocysteine intermediate By similarity

Experimental info

Sequence conflict423 – 4242DL → T in AAA33241. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P34137 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: EFCC04A0F6AEB8BF

FASTA52259,554
        10         20         30         40         50         60 
MGSVESSNQM NGSIENKTNK IDISVLRPLP TRSNSSISLS SSSHSSFSRM GSLGSLPTNS 

        70         80         90        100        110        120 
GSSSPYYNNS SFDLVDEERI KSSIYNLKNH IKCIHKIKEE FRLLEESVGP SETSEGDKKH 

       130        140        150        160        170        180 
NTSKNRYTNI LPVNHTRVQL KKIQDKEGSD YINANYIDGA YPKQFICTQG PLPNTIADFW 

       190        200        210        220        230        240 
RMVWENRCRI IVMLSRESEN CRIKCDRYWP EQIGGEQFSI YGNGNEVFGT YSVELVEVIQ 

       250        260        270        280        290        300 
DPEREIITRN IRLTFEGETR DITQYQYEGW PDHNIPDHTQ PFRQLLHSIT NRQNQIIPSS 

       310        320        330        340        350        360 
DRNVPIIVHC SAGVGRTGTF CTAVIMMKKL DHYFKQLDAT PIDQVVDPFT HLPITEYQSD 

       370        380        390        400        410        420 
NLDLKGLGYH FKSSIYNSNG INNNNNNNLN NNNNINNNSN GSNNTPQTEP NNEEDDDDAA 

       430        440        450        460        470        480 
ESDLKYAIMD KYNSRIDFNL FSIVLKLREQ RPGMVQQLEQ YLFCYKTILD EIYHRLNCKL 

       490        500        510        520 
GFSLPHVNNI NNYNNYSNTT TTTTSSLAST TIIHPSTNSK LN 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium."
Howard P.K., Sefton B.M., Firtel R.A.
Cell 71:637-647(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07125 Genomic DNA. Translation: AAA33241.1.
AAFI02000011 Genomic DNA. Translation: EAL70599.1.
AAFI02000009 Genomic DNA. Translation: EAL70766.1.
PIRA44267.

3D structure databases

ProteinModelPortalP34137.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0185117; DDB0185117; DDB_G0273097.
DDB0238491; DDB0238491; DDB_G0273817.
KEGGddi:DDB_G0273097.
ddi:DDB_G0273817.

Organism-specific databases

dictyBaseDDB_G0273097. ptpA1-1.
DDB_G0273817. ptpA1-2.

Phylogenomic databases

eggNOGCOG5599.
OMAENCRIKC.
PhylomeDBP34137.
ProtClustDBCLSZ2431184.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTP1_DICDI
AccessionPrimary (citable) accession number: P34137
Secondary accession number(s): Q556U4, Q86AJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase