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Protein

Neurotrophin-4

Gene

Ntf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could serve as a target-derived trophic factor for sensory and sympathetic neurons.

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: UniProtKB
  • cell-cell signaling Source: GO_Central
  • epidermis development Source: UniProtKB
  • ganglion mother cell fate determination Source: UniProtKB
  • innervation Source: Ensembl
  • long-term memory Source: UniProtKB
  • mechanoreceptor differentiation Source: Ensembl
  • negative regulation of neuron apoptotic process Source: GO_Central
  • neuron projection morphogenesis Source: GO_Central
  • regulation of neuron differentiation Source: GO_Central
  • regulation of synaptic plasticity Source: RGD
  • sensory organ boundary specification Source: UniProtKB
  • taste bud development Source: Ensembl
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-RNO-9026527 Activated NTRK2 signals through PLCG1
R-RNO-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:Ntf4
Synonyms:Nt4, Ntf5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi3212 Ntf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001967322 – 79Add BLAST58
ChainiPRO_000001967480 – 209Neurotrophin-4Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 169By similarity
Disulfide bondi140 ↔ 198By similarity
Disulfide bondi157 ↔ 200By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34131

PTM databases

PhosphoSitePlusiP34131

Expressioni

Tissue specificityi

Expressed in thymus, muscle, ovary, brain, heart, stomach and kidney. Expressed in both embryo and adult tissues.

Gene expression databases

BgeeiENSRNOG00000020783
GenevisibleiP34131 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028195

Structurei

3D structure databases

ProteinModelPortaliP34131
SMRiP34131
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIFY Eukaryota
ENOG4111839 LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP34131
KOiK12457
OMAiSVPMEPH
OrthoDBiEOG091G0GHL
PhylomeDBiP34131
TreeFamiTF106463

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR020432 Neurotrophin-4
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF8 PTHR11589:SF8, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01915 NEUROTROPHN4
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRHSCSLL LFLLLLPSVP MEPQPPSSTL PPFLAPEWDL LSPRVALSRG
60 70 80 90 100
TPAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS
110 120 130 140 150
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP
160 170 180 190 200
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC

TLLSRTGRA
Length:209
Mass (Da):22,333
Last modified:February 1, 1994 - v1
Checksum:iDF5112C05C5D5B85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177R → P in AAB20548 (PubMed:1313578).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69323 mRNA Translation: AAB20548.1
M86742 Genomic DNA Translation: AAA41728.1
PIRiB42687
RefSeqiNP_037316.2, NM_013184.3
UniGeneiRn.44225

Genome annotation databases

EnsembliENSRNOT00000028194; ENSRNOP00000028195; ENSRNOG00000020783
GeneIDi25730
KEGGirno:25730
UCSCiRGD:3212 rat

Similar proteinsi

Entry informationi

Entry nameiNTF4_RAT
AccessioniPrimary (citable) accession number: P34131
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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