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Protein

Neurotrophin-4

Gene

Ntf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could serve as a target-derived trophic factor for sensory and sympathetic neurons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-167021. PLC-gamma1 signalling.
R-RNO-167044. Signalling to RAS.
R-RNO-170968. Frs2-mediated activation.
R-RNO-170984. ARMS-mediated activation.
R-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-187042. TRKA activation by NGF.
R-RNO-187706. Signalling to p38 via RIT and RIN.
R-RNO-193648. NRAGE signals death through JNK.
R-RNO-198745. Signalling to STAT3.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:Ntf4
Synonyms:Nt4, Ntf5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3212. Ntf4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: GO_Central
  • endoplasmic reticulum lumen Source: UniProtKB
  • extracellular region Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 7958PRO_0000019673Add
BLAST
Chaini80 – 209130Neurotrophin-4PRO_0000019674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 169By similarity
Disulfide bondi140 ↔ 198By similarity
Disulfide bondi157 ↔ 200By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34131.

Expressioni

Tissue specificityi

Expressed in thymus, muscle, ovary, brain, heart, stomach and kidney. Expressed in both embryo and adult tissues.

Gene expression databases

GenevisibleiP34131. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1506472.
STRINGi10116.ENSRNOP00000028195.

Structurei

3D structure databases

ProteinModelPortaliP34131.
SMRiP34131. Positions 80-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIFY. Eukaryota.
ENOG4111839. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP34131.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP34131.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34131-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRHSCSLL LFLLLLPSVP MEPQPPSSTL PPFLAPEWDL LSPRVALSRG
60 70 80 90 100
TPAGPPLLFL LEAGAYGEPA GAPANRSRRG VSETAPASRR GELAVCDAVS
110 120 130 140 150
GWVTDRRTAV DLRGREVEVL GEVPAAGGSP LRQYFFETRC KAESAGEGGP
160 170 180 190 200
GVGGGGCRGV DRRHWLSECK AKQSYVRALT ADSQGRVGWR WIRIDTACVC

TLLSRTGRA
Length:209
Mass (Da):22,333
Last modified:February 1, 1994 - v1
Checksum:iDF5112C05C5D5B85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771R → P in AAB20548 (PubMed:1313578).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69323 mRNA. Translation: AAB20548.1.
M86742 Genomic DNA. Translation: AAA41728.1.
PIRiB42687.
RefSeqiNP_037316.2. NM_013184.3.
UniGeneiRn.44225.

Genome annotation databases

EnsembliENSRNOT00000028194; ENSRNOP00000028195; ENSRNOG00000020783.
GeneIDi25730.
KEGGirno:25730.
UCSCiRGD:3212. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S69323 mRNA. Translation: AAB20548.1.
M86742 Genomic DNA. Translation: AAA41728.1.
PIRiB42687.
RefSeqiNP_037316.2. NM_013184.3.
UniGeneiRn.44225.

3D structure databases

ProteinModelPortaliP34131.
SMRiP34131. Positions 80-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1506472.
STRINGi10116.ENSRNOP00000028195.

Proteomic databases

PaxDbiP34131.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028194; ENSRNOP00000028195; ENSRNOG00000020783.
GeneIDi25730.
KEGGirno:25730.
UCSCiRGD:3212. rat.

Organism-specific databases

CTDi4909.
RGDi3212. Ntf4.

Phylogenomic databases

eggNOGiENOG410IIFY. Eukaryota.
ENOG4111839. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP34131.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP34131.
TreeFamiTF106463.

Enzyme and pathway databases

ReactomeiR-RNO-167021. PLC-gamma1 signalling.
R-RNO-167044. Signalling to RAS.
R-RNO-170968. Frs2-mediated activation.
R-RNO-170984. ARMS-mediated activation.
R-RNO-177504. Retrograde neurotrophin signalling.
R-RNO-187042. TRKA activation by NGF.
R-RNO-187706. Signalling to p38 via RIT and RIN.
R-RNO-193648. NRAGE signals death through JNK.
R-RNO-198745. Signalling to STAT3.

Miscellaneous databases

PROiP34131.

Gene expression databases

GenevisibleiP34131. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB."
    Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., Rosenthal A.
    Neuron 7:857-866(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity."
    Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R., Belluscio L., le Beau M.M., Espinosa R. III, Squinto S.P., Persson H., Yancopoulos G.D.
    Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNTF4_RAT
AccessioniPrimary (citable) accession number: P34131
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.