ID NTF4_HUMAN Reviewed; 210 AA. AC P34130; Q6FH56; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 03-NOV-2009, entry version 91. DE RecName: Full=Neurotrophin-4; DE Short=NT-4; DE AltName: Full=Neutrophic factor 4; DE AltName: Full=Neurotrophin-5; DE Short=NT-5; DE Flags: Precursor; GN Name=NTF4; Synonyms=NTF5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=92075279; PubMed=1742028; DOI=10.1016/0896-6273(91)90287-A; RA Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., RA Rosenthal A.; RT "Neurotrophin-5: a novel neurotrophic factor that activates trk and RT trkB."; RL Neuron 7:857-866(1991). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Prostate; RX MEDLINE=92212967; PubMed=1313578; DOI=10.1073/pnas.89.7.3060; RA Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R., RA Belluscio L., le Beau M.M., Espinosa R. III, Squinto S.P., Persson H., RA Yancopoulos G.D.; RT "Mammalian neurotrophin-4: structure, chromosomal localization, tissue RT distribution, and receptor specificity."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS). RX MEDLINE=20095835; PubMed=10631974; RA Robinson R.C., Radziejewski C., Spraggon G., Greenwald J., RA Kostura M.R., Burtnick L.D., Stuart D.I., Choe S., Jones E.Y.; RT "The structures of the neurotrophin 4 homodimer and the brain-derived RT neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk- RT binding site."; RL Protein Sci. 8:2589-2597(1999). CC -!- FUNCTION: Target-derived survival factor for peripheral sensory CC sympathetic neurons. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Highest levels in prostate, lower levels in CC thymus, placenta, and skeletal muscle. Expressed in embryonic and CC adult tissues. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M86528; AAA60154.1; -; Genomic_DNA. DR EMBL; BT019368; AAV38175.1; -; mRNA. DR EMBL; BT019369; AAV38176.1; -; mRNA. DR EMBL; CR541900; CAG46698.1; -; mRNA. DR EMBL; BC012421; AAH12421.1; -; mRNA. DR IPI; IPI00030097; -. DR PIR; A42687; A42687. DR RefSeq; NP_006170.1; -. DR UniGene; Hs.266902; -. DR UniGene; Hs.711644; -. DR PDB; 1B8M; X-ray; 2.75 A; B=81-210. DR PDB; 1B98; X-ray; 2.75 A; A/M=81-210. DR PDB; 1HCF; X-ray; 2.70 A; A/B=81-210. DR PDBsum; 1B8M; -. DR PDBsum; 1B98; -. DR PDBsum; 1HCF; -. DR STRING; P34130; -. DR PRIDE; P34130; -. DR Ensembl; ENST00000301411; ENSP00000301411; ENSG00000167744; Homo sapiens. DR GeneID; 4909; -. DR KEGG; hsa:4909; -. DR UCSC; uc002pmf.2; human. DR CTD; 4909; -. DR GeneCards; GC19M054257; -. DR H-InvDB; HIX0015315; -. DR HGNC; HGNC:8024; NTF4. DR HPA; CAB010167; -. DR MIM; 162662; gene. DR PharmGKB; PA31807; -. DR HOGENOM; P34130; -. DR HOVERGEN; P34130; -. DR OMA; PRVALSR; -. DR Pathway_Interaction_DB; trkrpathway; Neurotrophic factor-mediated Trk receptor signaling. DR Pathway_Interaction_DB; p75ntrpathway; p75(NTR)-mediated signaling. DR NextBio; 18893; -. DR ArrayExpress; P34130; -. DR Bgee; P34130; -. DR CleanEx; HS_NTF4; -. DR Genevestigator; P34130; -. DR GermOnline; ENSG00000167744; Homo sapiens. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; TAS:ProtInc. DR GO; GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR InterPro; IPR020432; Neurotrophin-4. DR PANTHER; PTHR11589; NGF; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01915; NEUROTROPHN4. DR PRINTS; PR00268; NGF. DR ProDom; PD002052; NGF; 1. DR SMART; SM00140; NGF; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cleavage on pair of basic residues; Complete proteome; KW Disulfide bond; Glycoprotein; Growth factor; Secreted; Signal. FT SIGNAL 1 24 Potential. FT PROPEP 25 80 FT /FTId=PRO_0000019669. FT CHAIN 81 210 Neurotrophin-4. FT /FTId=PRO_0000019670. FT CARBOHYD 76 76 N-linked (GlcNAc...) (Potential). FT DISULFID 97 170 FT DISULFID 141 199 FT DISULFID 158 201 FT STRAND 83 85 FT HELIX 88 90 FT STRAND 95 97 FT STRAND 99 104 FT STRAND 109 112 FT STRAND 117 120 FT STRAND 136 141 FT TURN 146 148 FT STRAND 150 153 FT TURN 163 165 FT STRAND 168 182 FT STRAND 184 186 FT STRAND 189 203 SQ SEQUENCE 210 AA; 22427 MW; DBC6A30195E139AD CRC64; MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA //