Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurotrophin-4

Gene

NTF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Target-derived survival factor for peripheral sensory sympathetic neurons.

GO - Molecular functioni

  • growth factor activity Source: ProtInc
  • neurotrophin p75 receptor binding Source: GO_Central

GO - Biological processi

  • adult locomotory behavior Source: UniProtKB
  • cell-cell signaling Source: GO_Central
  • epidermis development Source: UniProtKB
  • ganglion mother cell fate determination Source: UniProtKB
  • innervation Source: Ensembl
  • long-term memory Source: UniProtKB
  • mechanoreceptor differentiation Source: Ensembl
  • negative regulation of neuron apoptotic process Source: GO_Central
  • neuron projection morphogenesis Source: GO_Central
  • regulation of neuron differentiation Source: GO_Central
  • sensory organ boundary specification Source: UniProtKB
  • taste bud development Source: Ensembl
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167744-MONOMER.
SIGNORiP34130.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:NTF4
Synonyms:NTF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8024. NTF4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: GO_Central
  • endoplasmic reticulum lumen Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Glaucoma 1, open angle, O (GLC1O)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
See also OMIM:613100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0631967C → Y in GLC1O; unknown pathological significance. 1 Publication1
Natural variantiVAR_06319784E → K in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs756962734dbSNPEnsembl.1
Natural variantiVAR_06320190R → H in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs766504681dbSNPEnsembl.1
Natural variantiVAR_063205206R → Q in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs121918428dbSNPEnsembl.1
Natural variantiVAR_063206206R → W in GLC1O; also found in patients with normal pressure glaucoma; unknown pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 PublicationsCorresponds to variant rs121918427dbSNPEnsembl.1
Natural variantiVAR_063209209R → G in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs200675509dbSNPEnsembl.1

Keywords - Diseasei

Glaucoma

Organism-specific databases

DisGeNETi4909.
MalaCardsiNTF4.
MIMi613100. phenotype.
OpenTargetsiENSG00000225950.
Orphaneti353225. Primary adult open-angle glaucoma.
PharmGKBiPA162398206.

Polymorphism and mutation databases

BioMutaiNTF4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000001966925 – 80Add BLAST56
ChainiPRO_000001967081 – 210Neurotrophin-4Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 170
Disulfide bondi141 ↔ 199
Disulfide bondi158 ↔ 201

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34130.
PeptideAtlasiP34130.
PRIDEiP34130.

PTM databases

iPTMnetiP34130.
PhosphoSitePlusiP34130.

Expressioni

Tissue specificityi

Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Gene expression databases

BgeeiENSG00000225950.
CleanExiHS_NTF4.
ExpressionAtlasiP34130. baseline and differential.
GenevisibleiP34130. HS.

Organism-specific databases

HPAiHPA049376.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-3907456,EBI-10173507

GO - Molecular functioni

  • growth factor activity Source: ProtInc
  • neurotrophin p75 receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi110964. 5 interactors.
IntActiP34130. 6 interactors.
MINTiMINT-1508589.
STRINGi9606.ENSP00000301411.

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi83 – 85Combined sources3
Helixi88 – 90Combined sources3
Beta strandi94 – 97Combined sources4
Beta strandi99 – 104Combined sources6
Beta strandi109 – 112Combined sources4
Beta strandi117 – 120Combined sources4
Beta strandi122 – 125Combined sources4
Beta strandi127 – 133Combined sources7
Beta strandi136 – 141Combined sources6
Turni146 – 148Combined sources3
Beta strandi153 – 156Combined sources4
Turni163 – 165Combined sources3
Beta strandi166 – 182Combined sources17
Beta strandi184 – 186Combined sources3
Beta strandi188 – 205Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8MX-ray2.75B81-210[»]
1B98X-ray2.75A/M81-210[»]
1HCFX-ray2.70A/B81-210[»]
ProteinModelPortaliP34130.
SMRiP34130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34130.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIFY. Eukaryota.
ENOG4111839. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP34130.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG091G0GHL.
PhylomeDBiP34130.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR
60 70 80 90 100
GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV
110 120 130 140 150
SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG
160 170 180 190 200
PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV
210
CTLLSRTGRA
Length:210
Mass (Da):22,427
Last modified:February 1, 1994 - v1
Checksum:iDBC6A30195E139AD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0631967C → Y in GLC1O; unknown pathological significance. 1 Publication1
Natural variantiVAR_06319784E → K in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs756962734dbSNPEnsembl.1
Natural variantiVAR_06319888A → V.2 PublicationsCorresponds to variant rs61732310dbSNPEnsembl.1
Natural variantiVAR_06319989S → N.1 PublicationCorresponds to variant rs374367338dbSNPEnsembl.1
Natural variantiVAR_06320090R → C.1 PublicationCorresponds to variant rs751743400dbSNPEnsembl.1
Natural variantiVAR_06320190R → H in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs766504681dbSNPEnsembl.1
Natural variantiVAR_063202114R → G.1 PublicationCorresponds to variant rs377553005dbSNPEnsembl.1
Natural variantiVAR_063203133R → H.1 Publication1
Natural variantiVAR_063204140R → C.1 PublicationCorresponds to variant rs201069064dbSNPEnsembl.1
Natural variantiVAR_063205206R → Q in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs121918428dbSNPEnsembl.1
Natural variantiVAR_063206206R → W in GLC1O; also found in patients with normal pressure glaucoma; unknown pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 PublicationsCorresponds to variant rs121918427dbSNPEnsembl.1
Natural variantiVAR_063207207T → I.1 PublicationCorresponds to variant rs371861346dbSNPEnsembl.1
Natural variantiVAR_063208207T → S.1 Publication1
Natural variantiVAR_063209209R → G in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant rs200675509dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86528 Genomic DNA. Translation: AAA60154.1.
BT019368 mRNA. Translation: AAV38175.1.
BT019369 mRNA. Translation: AAV38176.1.
CR541900 mRNA. Translation: CAG46698.1.
BC012421 mRNA. Translation: AAH12421.1.
CCDSiCCDS12754.1.
PIRiA42687.
RefSeqiNP_006170.1. NM_006179.4.
XP_005259019.1. XM_005258962.3.
XP_006723295.1. XM_006723232.3.
XP_011525311.1. XM_011527009.2.
XP_011525312.1. XM_011527010.2.
UniGeneiHs.266902.
Hs.743915.

Genome annotation databases

EnsembliENST00000593537; ENSP00000469455; ENSG00000225950.
GeneIDi4909.
KEGGihsa:4909.
UCSCiuc061ayz.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86528 Genomic DNA. Translation: AAA60154.1.
BT019368 mRNA. Translation: AAV38175.1.
BT019369 mRNA. Translation: AAV38176.1.
CR541900 mRNA. Translation: CAG46698.1.
BC012421 mRNA. Translation: AAH12421.1.
CCDSiCCDS12754.1.
PIRiA42687.
RefSeqiNP_006170.1. NM_006179.4.
XP_005259019.1. XM_005258962.3.
XP_006723295.1. XM_006723232.3.
XP_011525311.1. XM_011527009.2.
XP_011525312.1. XM_011527010.2.
UniGeneiHs.266902.
Hs.743915.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8MX-ray2.75B81-210[»]
1B98X-ray2.75A/M81-210[»]
1HCFX-ray2.70A/B81-210[»]
ProteinModelPortaliP34130.
SMRiP34130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110964. 5 interactors.
IntActiP34130. 6 interactors.
MINTiMINT-1508589.
STRINGi9606.ENSP00000301411.

PTM databases

iPTMnetiP34130.
PhosphoSitePlusiP34130.

Polymorphism and mutation databases

BioMutaiNTF4.

Proteomic databases

PaxDbiP34130.
PeptideAtlasiP34130.
PRIDEiP34130.

Protocols and materials databases

DNASUi4909.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593537; ENSP00000469455; ENSG00000225950.
GeneIDi4909.
KEGGihsa:4909.
UCSCiuc061ayz.1. human.

Organism-specific databases

CTDi4909.
DisGeNETi4909.
GeneCardsiNTF4.
HGNCiHGNC:8024. NTF4.
HPAiHPA049376.
MalaCardsiNTF4.
MIMi162662. gene.
613100. phenotype.
neXtProtiNX_P34130.
OpenTargetsiENSG00000225950.
Orphaneti353225. Primary adult open-angle glaucoma.
PharmGKBiPA162398206.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIFY. Eukaryota.
ENOG4111839. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP34130.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG091G0GHL.
PhylomeDBiP34130.
TreeFamiTF106463.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167744-MONOMER.
SIGNORiP34130.

Miscellaneous databases

EvolutionaryTraceiP34130.
GenomeRNAii4909.
PROiP34130.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000225950.
CleanExiHS_NTF4.
ExpressionAtlasiP34130. baseline and differential.
GenevisibleiP34130. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTF4_HUMAN
AccessioniPrimary (citable) accession number: P34130
Secondary accession number(s): Q6FH56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.