Neurotrophin-4 precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P34130 (NTF4_HUMAN)

Last modified June 16, 2009. Version 86. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Neurotrophin-4
      Short name=NT-4
Alternative name(s):
    Neutrophic factor 4
    Neurotrophin-5
      Short name=NT-5

Gene names

Name:	NTF4
Synonyms:	NTF5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Target-derived survival factor for peripheral sensory sympathetic neurons.
Subcellular location	Secreted.
Tissue specificity	Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
Sequence similarities	Belongs to the NGF-beta family.

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Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	regulation of synaptic plasticity Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	growth factor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Propeptide

25 – 80

PRO_0000019669

Chain

81 – 210

130

Neurotrophin-4

PRO_0000019670

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

97 ↔ 170

Disulfide bond

141 ↔ 199

Disulfide bond

158 ↔ 201

Secondary structure

210

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P34130-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: DBC6A30195E139AD
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FASTA

210

22,427

        10         20         30         40         50         60 
MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR GAPAGPPLLF 

        70         80         90        100        110        120 
LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV 

       130        140        150        160        170        180 
LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL 

       190        200        210 
TADAQGRVGW RWIRIDTACV CTLLSRTGRA

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB." Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., Rosenthal A. Neuron 7:857-866(1991) [PubMed: 1742028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity." Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R., Belluscio L., le Beau M.M., Espinosa R. III, Squinto S.P., Persson H., Yancopoulos G.D. Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992) [PubMed: 1313578] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Prostate.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[6]	"The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site." Robinson R.C., Radziejewski C., Spraggon G., Greenwald J., Kostura M.R., Burtnick L.D., Stuart D.I., Choe S., Jones E.Y. Protein Sci. 8:2589-2597(1999) [PubMed: 10631974] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS).
+	Additional computationally mapped references.

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Cross-references

Sequence databases

M86528 Genomic DNA. Translation: AAA60154.1.
BT019368 mRNA. Translation: AAV38175.1.
BT019369 mRNA. Translation: AAV38176.1.
CR541900 mRNA. Translation: CAG46698.1.
BC012421 mRNA. Translation: AAH12421.1.

IPI

IPI00030097.

PIR

A42687.

RefSeq

NP_006170.1.

UniGene

Hs.266902
Hs.711644

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B8M	X-ray	2.75	B	81-210	[»]
1B98	X-ray	2.75	A/M	81-210	[»]
1HCF	X-ray	2.70	A/B	81-210	[»]

ModBase

Search...

Proteomic databases

PRIDE

P34130.

Genome annotation databases

Ensembl

ENSG00000167744. Homo sapiens. [Contig view]

GeneID

4909.

KEGG

hsa:4909.

Organism-specific databases

GeneCards

GC19M054257.

H-InvDB

HIX0015315.

HGNC

HGNC:8024. NTF4.

HPA

CAB010167.

MIM

162662. gene.

PharmGKB

PA31807.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P34130.

HOVERGEN

P34130.

OMA

P34130. PRVALSR.

Enzyme and pathway databases

Pathway_Interaction_DB

trkrpathway. Neurotrophic factor-mediated Trk receptor signaling.
p75ntrpathway. p75(NTR)-mediated signaling.

Gene expression databases

ArrayExpress

P34130.

Bgee

P34130.

CleanEx

HS_NTF4.

GermOnline

ENSG00000167744. Homo sapiens.

Family and domain databases

InterPro

IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]

PANTHER

PTHR11589. NGF. 1 hit.

Pfam

PF00243. NGF. 1 hit.
[Graphical view]

PIRSF

PIRSF001789. NGF. 1 hit.

PRINTS

PR00268. NGF.

ProDom

PD002052. NGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00140. NGF. 1 hit.
[Graphical view]

PROSITE

PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

18893.

SOURCE

Search...

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Entry information

Entry name

NTF4_HUMAN

Accession

Primary (citable) accession number: P34130
Secondary accession number(s): Q6FH56

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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