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P34130

- NTF4_HUMAN

UniProt

P34130 - NTF4_HUMAN

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Protein

Neurotrophin-4

Gene
NTF4, NTF5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Target-derived survival factor for peripheral sensory sympathetic neurons.

GO - Molecular functioni

  1. growth factor activity Source: ProtInc

GO - Biological processi

  1. adult locomotory behavior Source: UniProtKB
  2. epidermis development Source: UniProtKB
  3. ganglion mother cell fate determination Source: UniProtKB
  4. long-term memory Source: UniProtKB
  5. mechanoreceptor differentiation Source: Ensembl
  6. sensory organ boundary specification Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:NTF4
Synonyms:NTF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8024. NTF4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
  2. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Keywords - Diseasei

Glaucoma

Organism-specific databases

MIMi613100. phenotype.
Orphaneti353225. Primary adult open-angle glaucoma.
PharmGKBiPA162398206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Propeptidei25 – 8056PRO_0000019669Add
BLAST
Chaini81 – 210130Neurotrophin-4PRO_0000019670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 170
Disulfide bondi141 ↔ 199
Disulfide bondi158 ↔ 201

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34130.
PRIDEiP34130.

Expressioni

Tissue specificityi

Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Gene expression databases

BgeeiP34130.
CleanExiHS_NTF4.
GenevestigatoriP34130.

Interactioni

Protein-protein interaction databases

BioGridi110964. 2 interactions.
IntActiP34130. 1 interaction.
MINTiMINT-1508589.
STRINGi9606.ENSP00000301411.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi83 – 853
Helixi88 – 903
Beta strandi94 – 974
Beta strandi99 – 1046
Beta strandi109 – 1124
Beta strandi117 – 1204
Beta strandi122 – 1254
Beta strandi127 – 1337
Beta strandi136 – 1416
Turni146 – 1483
Beta strandi153 – 1564
Turni163 – 1653
Beta strandi166 – 18217
Beta strandi188 – 20518

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B8MX-ray2.75B81-210[»]
1B98X-ray2.75A/M81-210[»]
1HCFX-ray2.70A/B81-210[»]
ProteinModelPortaliP34130.
SMRiP34130. Positions 85-208.

Miscellaneous databases

EvolutionaryTraceiP34130.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42623.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP34130.
KOiK12457.
OMAiRIRNGVF.
PhylomeDBiP34130.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34130-1 [UniParc]FASTAAdd to Basket

« Hide

MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR    50
GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV 100
SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG 150
PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV 200
CTLLSRTGRA 210
Length:210
Mass (Da):22,427
Last modified:February 1, 1994 - v1
Checksum:iDBC6A30195E139AD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71C → Y in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
VAR_063196
Natural varianti84 – 841E → K in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
VAR_063197
Natural varianti88 – 881A → V.2 Publications
VAR_063198
Natural varianti89 – 891S → N.1 Publication
VAR_063199
Natural varianti90 – 901R → C.1 Publication
VAR_063200
Natural varianti90 – 901R → H in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
VAR_063201
Natural varianti114 – 1141R → G.1 Publication
VAR_063202
Natural varianti133 – 1331R → H.1 Publication
VAR_063203
Natural varianti140 – 1401R → C.1 Publication
VAR_063204
Natural varianti206 – 2061R → Q in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
VAR_063205
Natural varianti206 – 2061R → W in patients with primary open-angle glaucoma and normal pressure glaucoma; uncertain pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 Publications
VAR_063206
Natural varianti207 – 2071T → I.1 Publication
VAR_063207
Natural varianti207 – 2071T → S.1 Publication
VAR_063208
Natural varianti209 – 2091R → G in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
VAR_063209

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86528 Genomic DNA. Translation: AAA60154.1.
BT019368 mRNA. Translation: AAV38175.1.
BT019369 mRNA. Translation: AAV38176.1.
CR541900 mRNA. Translation: CAG46698.1.
BC012421 mRNA. Translation: AAH12421.1.
CCDSiCCDS12754.1.
PIRiA42687.
RefSeqiNP_006170.1. NM_006179.4.
XP_005259019.1. XM_005258962.1.
XP_006723295.1. XM_006723232.1.
UniGeneiHs.266902.
Hs.743915.

Genome annotation databases

EnsembliENST00000301411; ENSP00000301411; ENSG00000225950.
ENST00000593537; ENSP00000469455; ENSG00000225950.
GeneIDi4909.
KEGGihsa:4909.
UCSCiuc002pmf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86528 Genomic DNA. Translation: AAA60154.1 .
BT019368 mRNA. Translation: AAV38175.1 .
BT019369 mRNA. Translation: AAV38176.1 .
CR541900 mRNA. Translation: CAG46698.1 .
BC012421 mRNA. Translation: AAH12421.1 .
CCDSi CCDS12754.1.
PIRi A42687.
RefSeqi NP_006170.1. NM_006179.4.
XP_005259019.1. XM_005258962.1.
XP_006723295.1. XM_006723232.1.
UniGenei Hs.266902.
Hs.743915.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B8M X-ray 2.75 B 81-210 [» ]
1B98 X-ray 2.75 A/M 81-210 [» ]
1HCF X-ray 2.70 A/B 81-210 [» ]
ProteinModelPortali P34130.
SMRi P34130. Positions 85-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110964. 2 interactions.
IntActi P34130. 1 interaction.
MINTi MINT-1508589.
STRINGi 9606.ENSP00000301411.

Proteomic databases

PaxDbi P34130.
PRIDEi P34130.

Protocols and materials databases

DNASUi 4909.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301411 ; ENSP00000301411 ; ENSG00000225950 .
ENST00000593537 ; ENSP00000469455 ; ENSG00000225950 .
GeneIDi 4909.
KEGGi hsa:4909.
UCSCi uc002pmf.4. human.

Organism-specific databases

CTDi 4909.
GeneCardsi GC19M049564.
HGNCi HGNC:8024. NTF4.
MIMi 162662. gene.
613100. phenotype.
neXtProti NX_P34130.
Orphaneti 353225. Primary adult open-angle glaucoma.
PharmGKBi PA162398206.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42623.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi P34130.
KOi K12457.
OMAi RIRNGVF.
PhylomeDBi P34130.
TreeFami TF106463.

Miscellaneous databases

EvolutionaryTracei P34130.
GenomeRNAii 4909.
NextBioi 18893.
PROi P34130.
SOURCEi Search...

Gene expression databases

Bgeei P34130.
CleanExi HS_NTF4.
Genevestigatori P34130.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB."
    Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., Rosenthal A.
    Neuron 7:857-866(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity."
    Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R., Belluscio L., le Beau M.M., Espinosa R. III, Squinto S.P., Persson H., Yancopoulos G.D.
    Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Prostate.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  6. "The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site."
    Robinson R.C., Radziejewski C., Spraggon G., Greenwald J., Kostura M.R., Burtnick L.D., Stuart D.I., Choe S., Jones E.Y.
    Protein Sci. 8:2589-2597(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS).
  7. Cited for: VARIANTS TYR-7; LYS-84; VAL-88; HIS-90; TRP-206; GLN-206; SER-207 AND GLY-209, CHARACTERIZATION OF VARIANT TRP-206, INVOLVEMENT IN SUSCEPTIBILITY TO GLAUCOMA.
  8. "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma."
    Liu Y., Liu W., Crooks K., Schmidt S., Allingham R.R., Hauser M.A.
    Am. J. Hum. Genet. 86:498-499(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-88; ASN-89; CYS-90; GLY-114; HIS-133; CYS-140; TRP-206 AND ILE-207, DISCUSSION OF ASSOCIATION WITH GLAUCOMA.

Entry informationi

Entry nameiNTF4_HUMAN
AccessioniPrimary (citable) accession number: P34130
Secondary accession number(s): Q6FH56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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