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P34130

- NTF4_HUMAN

UniProt

P34130 - NTF4_HUMAN

Protein

Neurotrophin-4

Gene

NTF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Target-derived survival factor for peripheral sensory sympathetic neurons.

    GO - Molecular functioni

    1. growth factor activity Source: ProtInc

    GO - Biological processi

    1. adult locomotory behavior Source: UniProtKB
    2. epidermis development Source: UniProtKB
    3. ganglion mother cell fate determination Source: UniProtKB
    4. long-term memory Source: UniProtKB
    5. mechanoreceptor differentiation Source: Ensembl
    6. sensory organ boundary specification Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrophin-4
    Short name:
    NT-4
    Alternative name(s):
    Neurotrophin-5
    Short name:
    NT-5
    Neutrophic factor 4
    Gene namesi
    Name:NTF4
    Synonyms:NTF5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8024. NTF4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB
    2. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
    Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry.

    Keywords - Diseasei

    Glaucoma

    Organism-specific databases

    MIMi613100. phenotype.
    Orphaneti353225. Primary adult open-angle glaucoma.
    PharmGKBiPA162398206.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 8056PRO_0000019669Add
    BLAST
    Chaini81 – 210130Neurotrophin-4PRO_0000019670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 170
    Disulfide bondi141 ↔ 199
    Disulfide bondi158 ↔ 201

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP34130.
    PRIDEiP34130.

    Expressioni

    Tissue specificityi

    Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

    Gene expression databases

    BgeeiP34130.
    CleanExiHS_NTF4.
    GenevestigatoriP34130.

    Interactioni

    Protein-protein interaction databases

    BioGridi110964. 2 interactions.
    IntActiP34130. 3 interactions.
    MINTiMINT-1508589.
    STRINGi9606.ENSP00000301411.

    Structurei

    Secondary structure

    1
    210
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi83 – 853
    Helixi88 – 903
    Beta strandi94 – 974
    Beta strandi99 – 1046
    Beta strandi109 – 1124
    Beta strandi117 – 1204
    Beta strandi122 – 1254
    Beta strandi127 – 1337
    Beta strandi136 – 1416
    Turni146 – 1483
    Beta strandi153 – 1564
    Turni163 – 1653
    Beta strandi166 – 18217
    Beta strandi188 – 20518

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B8MX-ray2.75B81-210[»]
    1B98X-ray2.75A/M81-210[»]
    1HCFX-ray2.70A/B81-210[»]
    ProteinModelPortaliP34130.
    SMRiP34130. Positions 85-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP34130.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42623.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiP34130.
    KOiK12457.
    OMAiRIRNGVF.
    PhylomeDBiP34130.
    TreeFamiTF106463.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR020432. Neurotrophin-4.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01915. NEUROTROPHN4.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR    50
    GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV 100
    SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG 150
    PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV 200
    CTLLSRTGRA 210
    Length:210
    Mass (Da):22,427
    Last modified:February 1, 1994 - v1
    Checksum:iDBC6A30195E139AD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71C → Y in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
    VAR_063196
    Natural varianti84 – 841E → K in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
    VAR_063197
    Natural varianti88 – 881A → V.2 Publications
    VAR_063198
    Natural varianti89 – 891S → N.1 Publication
    VAR_063199
    Natural varianti90 – 901R → C.1 Publication
    VAR_063200
    Natural varianti90 – 901R → H in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
    VAR_063201
    Natural varianti114 – 1141R → G.1 Publication
    VAR_063202
    Natural varianti133 – 1331R → H.1 Publication
    VAR_063203
    Natural varianti140 – 1401R → C.1 Publication
    VAR_063204
    Natural varianti206 – 2061R → Q in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
    VAR_063205
    Natural varianti206 – 2061R → W in patients with primary open-angle glaucoma and normal pressure glaucoma; uncertain pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 Publications
    VAR_063206
    Natural varianti207 – 2071T → I.1 Publication
    VAR_063207
    Natural varianti207 – 2071T → S.1 Publication
    VAR_063208
    Natural varianti209 – 2091R → G in a patient with primary open-angle glaucoma; uncertain pathological significance. 1 Publication
    VAR_063209

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86528 Genomic DNA. Translation: AAA60154.1.
    BT019368 mRNA. Translation: AAV38175.1.
    BT019369 mRNA. Translation: AAV38176.1.
    CR541900 mRNA. Translation: CAG46698.1.
    BC012421 mRNA. Translation: AAH12421.1.
    CCDSiCCDS12754.1.
    PIRiA42687.
    RefSeqiNP_006170.1. NM_006179.4.
    XP_005259019.1. XM_005258962.1.
    XP_006723295.1. XM_006723232.1.
    UniGeneiHs.266902.
    Hs.743915.

    Genome annotation databases

    EnsembliENST00000593537; ENSP00000469455; ENSG00000225950.
    GeneIDi4909.
    KEGGihsa:4909.
    UCSCiuc002pmf.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86528 Genomic DNA. Translation: AAA60154.1 .
    BT019368 mRNA. Translation: AAV38175.1 .
    BT019369 mRNA. Translation: AAV38176.1 .
    CR541900 mRNA. Translation: CAG46698.1 .
    BC012421 mRNA. Translation: AAH12421.1 .
    CCDSi CCDS12754.1.
    PIRi A42687.
    RefSeqi NP_006170.1. NM_006179.4.
    XP_005259019.1. XM_005258962.1.
    XP_006723295.1. XM_006723232.1.
    UniGenei Hs.266902.
    Hs.743915.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B8M X-ray 2.75 B 81-210 [» ]
    1B98 X-ray 2.75 A/M 81-210 [» ]
    1HCF X-ray 2.70 A/B 81-210 [» ]
    ProteinModelPortali P34130.
    SMRi P34130. Positions 85-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110964. 2 interactions.
    IntActi P34130. 3 interactions.
    MINTi MINT-1508589.
    STRINGi 9606.ENSP00000301411.

    Proteomic databases

    PaxDbi P34130.
    PRIDEi P34130.

    Protocols and materials databases

    DNASUi 4909.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000593537 ; ENSP00000469455 ; ENSG00000225950 .
    GeneIDi 4909.
    KEGGi hsa:4909.
    UCSCi uc002pmf.4. human.

    Organism-specific databases

    CTDi 4909.
    GeneCardsi GC19M049564.
    HGNCi HGNC:8024. NTF4.
    MIMi 162662. gene.
    613100. phenotype.
    neXtProti NX_P34130.
    Orphaneti 353225. Primary adult open-angle glaucoma.
    PharmGKBi PA162398206.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42623.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi P34130.
    KOi K12457.
    OMAi RIRNGVF.
    PhylomeDBi P34130.
    TreeFami TF106463.

    Miscellaneous databases

    EvolutionaryTracei P34130.
    GenomeRNAii 4909.
    NextBioi 18893.
    PROi P34130.
    SOURCEi Search...

    Gene expression databases

    Bgeei P34130.
    CleanExi HS_NTF4.
    Genevestigatori P34130.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR020432. Neurotrophin-4.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01915. NEUROTROPHN4.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB."
      Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., Rosenthal A.
      Neuron 7:857-866(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity."
      Ip N.Y., Ibanez C.F., Nye S.H., McClain J., Jones P.F., Gies D.R., Belluscio L., le Beau M.M., Espinosa R. III, Squinto S.P., Persson H., Yancopoulos G.D.
      Proc. Natl. Acad. Sci. U.S.A. 89:3060-3064(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Prostate.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    6. "The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site."
      Robinson R.C., Radziejewski C., Spraggon G., Greenwald J., Kostura M.R., Burtnick L.D., Stuart D.I., Choe S., Jones E.Y.
      Protein Sci. 8:2589-2597(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS).
    7. Cited for: VARIANTS TYR-7; LYS-84; VAL-88; HIS-90; TRP-206; GLN-206; SER-207 AND GLY-209, CHARACTERIZATION OF VARIANT TRP-206, INVOLVEMENT IN SUSCEPTIBILITY TO GLAUCOMA.
    8. "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma."
      Liu Y., Liu W., Crooks K., Schmidt S., Allingham R.R., Hauser M.A.
      Am. J. Hum. Genet. 86:498-499(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-88; ASN-89; CYS-90; GLY-114; HIS-133; CYS-140; TRP-206 AND ILE-207, DISCUSSION OF ASSOCIATION WITH GLAUCOMA.

    Entry informationi

    Entry nameiNTF4_HUMAN
    AccessioniPrimary (citable) accession number: P34130
    Secondary accession number(s): Q6FH56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3