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P34117

- CDK5_DICDI

UniProt

P34117 - CDK5_DICDI

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Protein

Cyclin-dependent kinase 5 homolog

Gene
cdk5, crp, crpA, DDB_G0288677
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei126 – 1261Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin binding Source: dictyBase
  3. cyclin-dependent protein serine/threonine kinase activity Source: dictyBase
  4. protein binding Source: dictyBase

GO - Biological processi

  1. aggregation involved in sorocarp development Source: dictyBase
  2. cell proliferation Source: dictyBase
  3. phagocytosis Source: dictyBase
  4. pinocytosis Source: dictyBase
  5. protein phosphorylation Source: dictyBase
  6. regulation of aggregate size involved in sorocarp development Source: dictyBase
  7. sporulation resulting in formation of a cellular spore Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 1939.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
Alternative name(s):
CDC2-like serine/threonine-protein kinase CRP
Cell division protein kinase 5
Gene namesi
Name:cdk5
Synonyms:crp, crpA
ORF Names:DDB_G0288677
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288677. cdk5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. intracellular Source: dictyBase
  3. nucleoplasm Source: dictyBase
  4. nucleus Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Cyclin-dependent kinase 5 homologPRO_0000085740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP34117.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0191155.

Structurei

3D structure databases

ProteinModelPortaliP34117.
SMRiP34117. Positions 1-285.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 285282Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK04563.
OMAiLDECGGE.
PhylomeDBiP34117.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34117-1 [UniParc]FASTAAdd to Basket

« Hide

MEKYSKIEKL GEGTYGIVYK AKNRETGEIV ALKRIRLDSE DEGVPCTAIR    50
EISLLKELKH PNIVRLHDVI HTERKLTLVF EYLDQDLKKY LDECGGEISK 100
PTIKSFMYQL LKGVAFCHDH RVLHRDLKPQ NLLINRKGEL KLADFGLARA 150
FGIPVRTYSH EVVTLWYRAP DVLMGSRKYS TPIDIWSAGC IFAEMASGRP 200
LFPGSGTSDQ LFRIFKILGT PNEESWPSIT ELPEYKTDFP VHPAHQLSSI 250
VHGLDEKGLN LLSKMLQYDP NQRITAAAAL KHPYFDGLEP IN 292
Length:292
Mass (Da):33,219
Last modified:December 4, 2007 - v2
Checksum:iD6829B15C0458526
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191Y → N in AAA16056. 1 Publication
Sequence conflicti189 – 1891G → L in AAA16056. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00652 mRNA. Translation: AAA16056.1.
AAFI02000120 Genomic DNA. Translation: EAL63070.1.
PIRiS40021.
RefSeqiXP_636601.1. XM_631509.1.

Genome annotation databases

EnsemblProtistsiDDB0191155; DDB0191155; DDB_G0288677.
GeneIDi8626776.
KEGGiddi:DDB_G0288677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00652 mRNA. Translation: AAA16056.1 .
AAFI02000120 Genomic DNA. Translation: EAL63070.1 .
PIRi S40021.
RefSeqi XP_636601.1. XM_631509.1.

3D structure databases

ProteinModelPortali P34117.
SMRi P34117. Positions 1-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191155.

Proteomic databases

PRIDEi P34117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191155 ; DDB0191155 ; DDB_G0288677 .
GeneIDi 8626776.
KEGGi ddi:DDB_G0288677.

Organism-specific databases

dictyBasei DDB_G0288677. cdk5.

Phylogenomic databases

eggNOGi COG0515.
KOi K04563.
OMAi LDECGGE.
PhylomeDBi P34117.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 1939.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation from a unicellular organism, Dictyostelium discoideum, of a highly-related cdc2 gene with characteristics of the PCTAIRE subfamily."
    Michaelis C.E., Weeks G.
    Biochim. Biophys. Acta 1179:117-124(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCDK5_DICDI
AccessioniPrimary (citable) accession number: P34117
Secondary accession number(s): Q54II5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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