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Protein

Cyclin-dependent kinase 5 homolog

Gene

cdk5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: dictyBase
  • cyclin-dependent protein serine/threonine kinase activity Source: dictyBase

GO - Biological processi

  • aggregation involved in sorocarp development Source: dictyBase
  • asexual reproduction Source: dictyBase
  • phagocytosis Source: dictyBase
  • pinocytosis Source: dictyBase
  • protein phosphorylation Source: dictyBase
  • regulation of aggregate size involved in sorocarp development Source: dictyBase
  • sporulation resulting in formation of a cellular spore Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 1939.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
Alternative name(s):
CDC2-like serine/threonine-protein kinase CRP
Cell division protein kinase 5
Gene namesi
Name:cdk5
Synonyms:crp, crpA
ORF Names:DDB_G0288677
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288677. cdk5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • intracellular Source: dictyBase
  • nucleoplasm Source: dictyBase
  • nucleus Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857401 – 292Cyclin-dependent kinase 5 homologAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP34117.
PRIDEiP34117.

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: dictyBase

Protein-protein interaction databases

STRINGi44689.DDB0191155.

Structurei

3D structure databases

ProteinModelPortaliP34117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 285Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
InParanoidiP34117.
KOiK04563.
OMAiFGEMASG.
PhylomeDBiP34117.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYSKIEKL GEGTYGIVYK AKNRETGEIV ALKRIRLDSE DEGVPCTAIR
60 70 80 90 100
EISLLKELKH PNIVRLHDVI HTERKLTLVF EYLDQDLKKY LDECGGEISK
110 120 130 140 150
PTIKSFMYQL LKGVAFCHDH RVLHRDLKPQ NLLINRKGEL KLADFGLARA
160 170 180 190 200
FGIPVRTYSH EVVTLWYRAP DVLMGSRKYS TPIDIWSAGC IFAEMASGRP
210 220 230 240 250
LFPGSGTSDQ LFRIFKILGT PNEESWPSIT ELPEYKTDFP VHPAHQLSSI
260 270 280 290
VHGLDEKGLN LLSKMLQYDP NQRITAAAAL KHPYFDGLEP IN
Length:292
Mass (Da):33,219
Last modified:December 4, 2007 - v2
Checksum:iD6829B15C0458526
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19Y → N in AAA16056 (PubMed:8218353).Curated1
Sequence conflicti189G → L in AAA16056 (PubMed:8218353).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00652 mRNA. Translation: AAA16056.1.
AAFI02000120 Genomic DNA. Translation: EAL63070.1.
PIRiS40021.
RefSeqiXP_636601.1. XM_631509.1.

Genome annotation databases

EnsemblProtistsiEAL63070; EAL63070; DDB_G0288677.
GeneIDi8626776.
KEGGiddi:DDB_G0288677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00652 mRNA. Translation: AAA16056.1.
AAFI02000120 Genomic DNA. Translation: EAL63070.1.
PIRiS40021.
RefSeqiXP_636601.1. XM_631509.1.

3D structure databases

ProteinModelPortaliP34117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0191155.

Proteomic databases

PaxDbiP34117.
PRIDEiP34117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL63070; EAL63070; DDB_G0288677.
GeneIDi8626776.
KEGGiddi:DDB_G0288677.

Organism-specific databases

dictyBaseiDDB_G0288677. cdk5.

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
InParanoidiP34117.
KOiK04563.
OMAiFGEMASG.
PhylomeDBiP34117.

Enzyme and pathway databases

BRENDAi2.7.11.22. 1939.

Miscellaneous databases

PROiP34117.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK5_DICDI
AccessioniPrimary (citable) accession number: P34117
Secondary accession number(s): Q54II5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.