Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P34117

- CDK5_DICDI

UniProt

P34117 - CDK5_DICDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cyclin-dependent kinase 5 homolog

Gene

cdk5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin binding Source: dictyBase
  3. cyclin-dependent protein serine/threonine kinase activity Source: dictyBase

GO - Biological processi

  1. aggregation involved in sorocarp development Source: dictyBase
  2. cell proliferation Source: dictyBase
  3. phagocytosis Source: dictyBase
  4. pinocytosis Source: dictyBase
  5. protein phosphorylation Source: dictyBase
  6. regulation of aggregate size involved in sorocarp development Source: dictyBase
  7. regulation of cell cycle Source: GOC
  8. sporulation resulting in formation of a cellular spore Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 1939.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
Alternative name(s):
CDC2-like serine/threonine-protein kinase CRP
Cell division protein kinase 5
Gene namesi
Name:cdk5
Synonyms:crp, crpA
ORF Names:DDB_G0288677
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0288677. cdk5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. intracellular Source: dictyBase
  3. nucleoplasm Source: dictyBase
  4. nucleus Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Cyclin-dependent kinase 5 homologPRO_0000085740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP34117.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0191155.

Structurei

3D structure databases

ProteinModelPortaliP34117.
SMRiP34117. Positions 1-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 285282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiP34117.
KOiK04563.
OMAiLDECGGE.
PhylomeDBiP34117.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34117 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKYSKIEKL GEGTYGIVYK AKNRETGEIV ALKRIRLDSE DEGVPCTAIR
60 70 80 90 100
EISLLKELKH PNIVRLHDVI HTERKLTLVF EYLDQDLKKY LDECGGEISK
110 120 130 140 150
PTIKSFMYQL LKGVAFCHDH RVLHRDLKPQ NLLINRKGEL KLADFGLARA
160 170 180 190 200
FGIPVRTYSH EVVTLWYRAP DVLMGSRKYS TPIDIWSAGC IFAEMASGRP
210 220 230 240 250
LFPGSGTSDQ LFRIFKILGT PNEESWPSIT ELPEYKTDFP VHPAHQLSSI
260 270 280 290
VHGLDEKGLN LLSKMLQYDP NQRITAAAAL KHPYFDGLEP IN
Length:292
Mass (Da):33,219
Last modified:December 4, 2007 - v2
Checksum:iD6829B15C0458526
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191Y → N in AAA16056. (PubMed:8218353)Curated
Sequence conflicti189 – 1891G → L in AAA16056. (PubMed:8218353)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00652 mRNA. Translation: AAA16056.1.
AAFI02000120 Genomic DNA. Translation: EAL63070.1.
PIRiS40021.
RefSeqiXP_636601.1. XM_631509.1.

Genome annotation databases

EnsemblProtistsiDDB0191155; DDB0191155; DDB_G0288677.
GeneIDi8626776.
KEGGiddi:DDB_G0288677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00652 mRNA. Translation: AAA16056.1 .
AAFI02000120 Genomic DNA. Translation: EAL63070.1 .
PIRi S40021.
RefSeqi XP_636601.1. XM_631509.1.

3D structure databases

ProteinModelPortali P34117.
SMRi P34117. Positions 1-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191155.

Proteomic databases

PRIDEi P34117.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191155 ; DDB0191155 ; DDB_G0288677 .
GeneIDi 8626776.
KEGGi ddi:DDB_G0288677.

Organism-specific databases

dictyBasei DDB_G0288677. cdk5.

Phylogenomic databases

eggNOGi COG0515.
InParanoidi P34117.
KOi K04563.
OMAi LDECGGE.
PhylomeDBi P34117.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 1939.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation from a unicellular organism, Dictyostelium discoideum, of a highly-related cdc2 gene with characteristics of the PCTAIRE subfamily."
    Michaelis C.E., Weeks G.
    Biochim. Biophys. Acta 1179:117-124(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCDK5_DICDI
AccessioniPrimary (citable) accession number: P34117
Secondary accession number(s): Q54II5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3