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P34117

- CDK5_DICDI

UniProt

P34117 - CDK5_DICDI

Protein

Cyclin-dependent kinase 5 homolog

Gene

cdk5

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calmodulin binding Source: dictyBase
    3. cyclin-dependent protein serine/threonine kinase activity Source: dictyBase
    4. protein binding Source: dictyBase

    GO - Biological processi

    1. aggregation involved in sorocarp development Source: dictyBase
    2. cell proliferation Source: dictyBase
    3. phagocytosis Source: dictyBase
    4. pinocytosis Source: dictyBase
    5. protein phosphorylation Source: dictyBase
    6. regulation of aggregate size involved in sorocarp development Source: dictyBase
    7. regulation of cell cycle Source: GOC
    8. sporulation resulting in formation of a cellular spore Source: dictyBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 1939.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 5 homolog (EC:2.7.11.22)
    Alternative name(s):
    CDC2-like serine/threonine-protein kinase CRP
    Cell division protein kinase 5
    Gene namesi
    Name:cdk5
    Synonyms:crp, crpA
    ORF Names:DDB_G0288677
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0288677. cdk5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: dictyBase
    2. intracellular Source: dictyBase
    3. nucleoplasm Source: dictyBase
    4. nucleus Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Cyclin-dependent kinase 5 homologPRO_0000085740Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP34117.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0191155.

    Structurei

    3D structure databases

    ProteinModelPortaliP34117.
    SMRiP34117. Positions 1-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 285282Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK04563.
    OMAiLDECGGE.
    PhylomeDBiP34117.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34117-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKYSKIEKL GEGTYGIVYK AKNRETGEIV ALKRIRLDSE DEGVPCTAIR    50
    EISLLKELKH PNIVRLHDVI HTERKLTLVF EYLDQDLKKY LDECGGEISK 100
    PTIKSFMYQL LKGVAFCHDH RVLHRDLKPQ NLLINRKGEL KLADFGLARA 150
    FGIPVRTYSH EVVTLWYRAP DVLMGSRKYS TPIDIWSAGC IFAEMASGRP 200
    LFPGSGTSDQ LFRIFKILGT PNEESWPSIT ELPEYKTDFP VHPAHQLSSI 250
    VHGLDEKGLN LLSKMLQYDP NQRITAAAAL KHPYFDGLEP IN 292
    Length:292
    Mass (Da):33,219
    Last modified:December 4, 2007 - v2
    Checksum:iD6829B15C0458526
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191Y → N in AAA16056. (PubMed:8218353)Curated
    Sequence conflicti189 – 1891G → L in AAA16056. (PubMed:8218353)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00652 mRNA. Translation: AAA16056.1.
    AAFI02000120 Genomic DNA. Translation: EAL63070.1.
    PIRiS40021.
    RefSeqiXP_636601.1. XM_631509.1.

    Genome annotation databases

    EnsemblProtistsiDDB0191155; DDB0191155; DDB_G0288677.
    GeneIDi8626776.
    KEGGiddi:DDB_G0288677.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00652 mRNA. Translation: AAA16056.1 .
    AAFI02000120 Genomic DNA. Translation: EAL63070.1 .
    PIRi S40021.
    RefSeqi XP_636601.1. XM_631509.1.

    3D structure databases

    ProteinModelPortali P34117.
    SMRi P34117. Positions 1-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0191155.

    Proteomic databases

    PRIDEi P34117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0191155 ; DDB0191155 ; DDB_G0288677 .
    GeneIDi 8626776.
    KEGGi ddi:DDB_G0288677.

    Organism-specific databases

    dictyBasei DDB_G0288677. cdk5.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K04563.
    OMAi LDECGGE.
    PhylomeDBi P34117.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 1939.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The isolation from a unicellular organism, Dictyostelium discoideum, of a highly-related cdc2 gene with characteristics of the PCTAIRE subfamily."
      Michaelis C.E., Weeks G.
      Biochim. Biophys. Acta 1179:117-124(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCDK5_DICDI
    AccessioniPrimary (citable) accession number: P34117
    Secondary accession number(s): Q54II5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3