Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase 1

Gene

cdk1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-20 or Tyr-21 inactivates the enzyme, while phosphorylation at Thr-162 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39ATPPROSITE-ProRule annotation1
Active sitei129Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: dictyBase
  • cyclin-dependent protein serine/threonine kinase activity Source: dictyBase
  • RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 1939
ReactomeiR-DDI-110056 MAPK3 (ERK1) activation
R-DDI-1538133 G0 and Early G1
R-DDI-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2 homolog
Cell division protein kinase 1
p34 protein kinase
Gene namesi
Name:cdk1
Synonyms:cdcB
ORF Names:DDB_G0272813
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272813 cdk1

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • intracellular Source: dictyBase
  • mitotic spindle Source: GO_Central
  • nucleus Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857391 – 296Cyclin-dependent kinase 1Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphothreonineBy similarity1
Modified residuei21PhosphotyrosineBy similarity1
Modified residuei162Phosphothreonine; by CAKBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP34112
PRIDEiP34112

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.

Protein-protein interaction databases

STRINGi44689.DDB0185028

Structurei

3D structure databases

ProteinModelPortaliP34112
SMRiP34112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST279

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
InParanoidiP34112
KOiK02206
OMAiLHIMRII
PhylomeDBiP34112

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P34112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESDGGLSRY QKLEKLGEGT YGKVYKAKEK ATGRMVALKK IRLEDDGVPS
60 70 80 90 100
TALREISLLK EVPHPNVVSL FDVLHCQNRL YLVFEYLDQD LKKYMDSVPA
110 120 130 140 150
LCPQLIKSYL YQLLKGLAYS HGHRILHRDL KPQNLLIDRQ GALKLADFGL
160 170 180 190 200
ARAVSIPVRV YTHEIVTLWY RAPEVLLGSK SYSVPVDMWS VGCIFGEMLN
210 220 230 240 250
KKPLFSGDCE IDQIFRIFRV LGTPDDSIWP GVTKLPEYVS TFPNWPGQPY
260 270 280 290
NKIFPRCEPL ALDLIAKMLQ YEPSKRISAK EALLHPYFGD LDTSFF
Length:296
Mass (Da):33,773
Last modified:February 1, 1994 - v1
Checksum:i406B53820AA677B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80808 mRNA Translation: AAA33178.1
AAFI02000008 Genomic DNA Translation: EAL71044.1
PIRiS24386
RefSeqiXP_644979.1, XM_639887.1

Genome annotation databases

EnsemblProtistsiEAL71044; EAL71044; DDB_G0272813
GeneIDi8618656
KEGGiddi:DDB_G0272813

Similar proteinsi

Entry informationi

Entry nameiCDK1_DICDI
AccessioniPrimary (citable) accession number: P34112
Secondary accession number(s): Q558T7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health