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P34102 (PK3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein kinase 3
Short name=PK3
EC=2.7.11.1
Gene names
Name:pkgC
ORF Names:DDB_G0286125
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 910910Protein kinase 3
PRO_0000086548

Regions

Domain498 – 763266Protein kinase
Domain764 – 85491AGC-kinase C-terminal
Nucleotide binding504 – 5129ATP By similarity
Compositional bias119 – 269151Ser-rich
Compositional bias226 – 28055Asn-rich
Compositional bias282 – 2909Poly-Thr
Compositional bias391 – 44353Asn-rich
Compositional bias469 – 4724Poly-Ser
Compositional bias879 – 8824Poly-Asn

Sites

Active site6211Proton acceptor By similarity
Binding site5271ATP By similarity

Amino acid modifications

Modified residue6641Phosphothreonine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P34102 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: 298EE6422EE86BFD

FASTA91099,305
        10         20         30         40         50         60 
MSFKKQTKTP TSWFPGLKKE RDLSHHKERY CTQYDVIKVN AYGKRQQRTL AVSSLGVSNL 

        70         80         90        100        110        120 
NGQSCQWFVR NSDVYSIEQD PTDSHKFSLT FLHRYHFEAE TPEQAKSIIS EFKRLGVGSP 

       130        140        150        160        170        180 
SGGGGGGSGV SSNGSNSTAT SPNTSPIRLY VSDPSNQPTS SSPPPQPPLS ESVGVHRSSP 

       190        200        210        220        230        240 
MLSSSRMISQ LSQSTSENNI SSPTYHPQGL SGSSTSSSSA SGGGGNNNNA NNSTPPNLIA 

       250        260        270        280        290        300 
SSASNSSLYS SSINSSGIIN SSNNNSSISF NNNNNNNNSN LTTTTTTTST FKTPTLPISQ 

       310        320        330        340        350        360 
ASKFNNESES MGLSPLTPNS NSQTALMQHI NAMPNTPNSN STEGSRVWKI RAEELKKQFL 

       370        380        390        400        410        420 
LKKSSKSTQT VATTTPTPIT KADIKIVLDD NKDDKNKDNN IGSGGSGNSS SKINKEKDNP 

       430        440        450        460        470        480 
YINQPSSLPS NNNSNNNNIT KSNSTTTSQT NDKKDVCSST INFDNLEVSS SSDRDLSSSK 

       490        500        510        520        530        540 
SLNKKNKQSI KKLTIDDFEL LKVLGVGSFG RVYLVRRKDT GKFYAMKVLN KKDMLKKKQI 

       550        560        570        580        590        600 
AHTNTEKMVL STMDHPFIVR LHFAFQNEDF LFMCMDYVPG GELFHHLQKA GKFPEELAKF 

       610        620        630        640        650        660 
YIAEVICSLH YLHSNNIIYR DIKPENILLD EEGHIKLTDF GLSKSGITSV VGSKNGGEGG 

       670        680        690        700        710        720 
FATTFCGTPE YLAPEIITGA GHGKAADWWS VGILLFEMLT GRSPFLASNR NDMYKSMIQG 

       730        740        750        760        770        780 
NLRMPMFLSS DAQDLLEKLL VPDPNKRLGS TQGFEEISSH PFFELIPWRM LESKMITPPF 

       790        800        810        820        830        840 
KPTIKEISLP NSNSNSNNNS QQPTNNNLTL SCDPELNAKI NFQRRKSSAA SVYNLDSPFK 

       850        860        870        880        890        900 
NFSWNKEEED GIMGERESIG SISSNNSISS SPTSSSPINN NNSGGSNTAG GHRILTRKST 

       910 
IGKNLRKGSV

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Identification of a protein kinase multigene family of Dictyostelium discoideum: molecular cloning and expression of a cDNA encoding a developmentally regulated protein kinase."
Haribabu B., Dottin R.P.
Proc. Natl. Acad. Sci. U.S.A. 88:1115-1119(1991) [PubMed: 1996312] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 626-666.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFI02000085 Genomic DNA. Translation: EAL64355.1.
M59746 Genomic DNA. Translation: AAA33188.1.
PIRC38578.
RefSeqXP_637858.1. XM_632766.1.

3D structure databases

ProteinModelPortalP34102.
ModBaseSearch...

Protein-protein interaction databases

STRINGP34102.

Proteomic databases

PRIDEP34102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0220130; DDB0220130; DDB_G0286125.
GeneID8625455.
GenomeReviewsGene locus pkgC in contig CM000153_GR.
KEGGddi:DDB_G0286125.

Organism-specific databases

dictyBaseDDB_G0286125. pkgC.

Phylogenomic databases

eggNOGKOG0598.
GeneTreeEPrGT00050000001059.
PhylomeDBP34102.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePK3_DICDI
AccessionPrimary (citable) accession number: P34102
Secondary accession number(s): Q54M90
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: September 21, 2011
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

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