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Protein

Pore-forming peptide ameobapore A

Gene
N/A
Organism
Entamoeba histolytica
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms pores in the cytoplasmic membrane of host cells. Has antibacterial activity against M.luteus, no activity against E.coli. Implicated in the cytolytic activity of the parasite.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Protein family/group databases

TCDBi1.C.35.1.1. the amoebapore (amoebapore) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Pore-forming peptide ameobapore A
Alternative name(s):
EH-APP
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
PeptideiPRO_000003166822 – 98Pore-forming peptide ameobapore AAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 98PROSITE-ProRule annotation
Disulfide bondi29 ↔ 92PROSITE-ProRule annotation
Disulfide bondi56 ↔ 67PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi5759.rna_EHI_159480-1.

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 39Combined sources14
Beta strandi41 – 43Combined sources3
Helixi46 – 56Combined sources11
Helixi64 – 73Combined sources10
Helixi75 – 84Combined sources10
Helixi88 – 95Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OF9NMR-A22-98[»]
ProteinModelPortaliP34095.
SMRiP34095.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34095.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 98Saposin B-typePROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Contains 1 saposin B-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
InterProiIPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF03489. SapB_2. 1 hit.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIVFVLIF AVAFAVTATH QGEILCNLCT GLINTLENLL TTKGADKVKD
60 70 80 90
YISSLCNKAS GFIATLCTKV LDFGIDKLIQ LIEDKVDANA ICAKIHAC
Length:98
Mass (Da):10,504
Last modified:February 1, 1994 - v1
Checksum:iF9592FDC1FAC7FFA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti71L → F.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83945 mRNA. Translation: AAA29111.1.
X70851 Genomic DNA. Translation: CAA50203.1.
PIRiS25283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83945 mRNA. Translation: AAA29111.1.
X70851 Genomic DNA. Translation: CAA50203.1.
PIRiS25283.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OF9NMR-A22-98[»]
ProteinModelPortaliP34095.
SMRiP34095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5759.rna_EHI_159480-1.

Protein family/group databases

TCDBi1.C.35.1.1. the amoebapore (amoebapore) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP34095.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
InterProiIPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
[Graphical view]
PfamiPF03489. SapB_2. 1 hit.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPFPA_ENTHI
AccessioniPrimary (citable) accession number: P34095
Secondary accession number(s): Q24839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.