UniProtKB - P34082 (FAS2_DROME)
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Protein
Fasciclin-2
Gene
Fas2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles.1 Publication
Caution
GO - Biological processi
- axonal fasciculation Source: FlyBase
- behavioral response to ethanol Source: FlyBase
- Bolwig's organ morphogenesis Source: FlyBase
- cell morphogenesis involved in neuron differentiation Source: FlyBase
- homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
- imaginal disc-derived male genitalia morphogenesis Source: FlyBase
- learning Source: FlyBase
- learning or memory Source: FlyBase
- motor neuron axon guidance Source: FlyBase
- mushroom body development Source: FlyBase
- negative regulation of epidermal growth factor receptor signaling pathway Source: FlyBase
- negative regulation of neuron remodeling Source: FlyBase
- neuromuscular junction development Source: FlyBase
- neuron recognition Source: FlyBase
- olfactory learning Source: FlyBase
- photoreceptor cell axon guidance Source: FlyBase
- regulation of cell shape Source: FlyBase
- regulation of synapse structure or activity Source: FlyBase
- regulation of synaptic growth at neuromuscular junction Source: FlyBase
- regulation of synaptic plasticity Source: FlyBase
- regulation of tube architecture, open tracheal system Source: FlyBase
- regulation of tube diameter, open tracheal system Source: FlyBase
- regulation of tube length, open tracheal system Source: FlyBase
- short-term memory Source: FlyBase
- synapse organization Source: FlyBase
- terminal button organization Source: FlyBase
Keywordsi
Molecular function | Developmental protein |
Biological process | Cell adhesion, Differentiation, Neurogenesis |
Enzyme and pathway databases
Reactomei | R-DME-375165 NCAM signaling for neurite out-growth R-DME-419037 NCAM1 interactions R-DME-445144 Signal transduction by L1 R-DME-5673001 RAF/MAP kinase cascade |
Names & Taxonomyi
Protein namesi | Recommended name: Fasciclin-2Alternative name(s): Fasciclin II Short name: FAS II |
Gene namesi | Name:Fas2 ORF Names:CG3665 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000635 Fas2 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 751 | ExtracellularSequence analysisAdd BLAST | 723 | |
Transmembranei | 752 – 769 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 770 – 873 | CytoplasmicSequence analysisAdd BLAST | 104 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000014758 | 29 – 873 | Fasciclin-2Add BLAST | 845 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 116 | PROSITE-ProRule annotation | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 159 ↔ 207 | PROSITE-ProRule annotation | ||
Glycosylationi | 250 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 251 ↔ 302 | PROSITE-ProRule annotation | ||
Glycosylationi | 330 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 343 ↔ 407 | PROSITE-ProRule annotation | ||
Glycosylationi | 448 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 451 ↔ 504 | PROSITE-ProRule annotation | ||
Glycosylationi | 458 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 576 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 827 | Phosphoserine1 Publication | 1 | |
Modified residuei | 841 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 845 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, PhosphoproteinProteomic databases
PaxDbi | P34082 |
PRIDEi | P34082 |
PTM databases
iPTMneti | P34082 |
Expressioni
Tissue specificityi
In embryos, both isoforms are initially expressed on the surface of the axons in the MP1 pathway and later on several other longitudinal axon fascicles.1 Publication
Gene expression databases
Bgeei | FBgn0000635 |
ExpressionAtlasi | P34082 differential |
Genevisiblei | P34082 DM |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 57881294 interactors. |
IntActi | P34082 671 interactors. |
STRINGi | 7227.FBpp0070633 |
Structurei
3D structure databases
ProteinModelPortali | P34082 |
SMRi | P34082 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 131 | Ig-like C2-type 1Add BLAST | 101 | |
Domaini | 138 – 223 | Ig-like C2-type 2Add BLAST | 86 | |
Domaini | 230 – 318 | Ig-like C2-type 3Add BLAST | 89 | |
Domaini | 323 – 423 | Ig-like C2-type 4Add BLAST | 101 | |
Domaini | 428 – 520 | Ig-like C2-type 5Add BLAST | 93 | |
Domaini | 524 – 622 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 638 – 738 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 101 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IQJI Eukaryota ENOG410XTGB LUCA |
GeneTreei | ENSGT00910000144011 |
InParanoidi | P34082 |
KOi | K06491 |
OMAi | VDWLYNG |
OrthoDBi | EOG091G02K3 |
PhylomeDBi | P34082 |
Family and domain databases
CDDi | cd00063 FN3, 2 hits |
Gene3Di | 2.60.40.107 hits |
InterProi | View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR009138 Neural_cell_adh |
Pfami | View protein in Pfam PF00041 fn3, 2 hits PF07679 I-set, 3 hits |
PRINTSi | PR01838 NCAMFAMILY |
SMARTi | View protein in SMART SM00060 FN3, 2 hits SM00409 IG, 5 hits SM00408 IGc2, 5 hits |
SUPFAMi | SSF48726 SSF48726, 5 hits SSF49265 SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853 FN3, 2 hits PS50835 IG_LIKE, 5 hits |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P34082-1) [UniParc]FASTAAdd to basket
Also known as: A, Membrane-linked
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGELPPNSVG VFLALLLCSC SLIELTRAQS PILEIYPKQE VQRKPVGKPL
60 70 80 90 100
ILTCRPTVPE PSLVADLQWK DNRNNTILPK PNGRNQPPMY TETLPGESLA
110 120 130 140 150
LMITSLSVEM GGKYYCTASY ANTEILEKGV TIKTYVAITW TNAPENQYPT
160 170 180 190 200
LGQDYVVMCE VKADPNPTID WLRNGDPIRT TNDKYVVQTN GLLIRNVQES
210 220 230 240 250
DEGIYTCRAA VIETGELLER TIRVEVFIQP EIISLPTNLE AVEGKPFAAN
260 270 280 290 300
CTARGKPVPE ISWIRDATQL NVATADRFQV NPQTGLVTIS SVSQDDYGTY
310 320 330 340 350
TCLAKNRAGV VDQKTKLNVL VRPQIYELYN VTGARTKEIA ITCRAKGRPA
360 370 380 390 400
PAITFRRWGT QEEYTNGQQD DDPRIILEPN FDEERGESTG TLRISNAERS
410 420 430 440 450
DDGLYQCIAR NKGADAYKTG HITVEFAPDF SHMKELPPVF SWEQRKANLS
460 470 480 490 500
CLAMGIPNAT IEWHWNGRKI KDLYDTNLKI VGTGPRSDLI VHPVTRQYYS
510 520 530 540 550
GYKCIATNIH GTAEHDMQLK EARVPDFVSE AKPSQLTATT MTFDIRGPST
560 570 580 590 600
ELGLPILAYS VQYKEALNPD WSTAYNRSWS PDSPYIVEGL RPQTEYSFRF
610 620 630 640 650
AARNQVGLGN WGVNQQQSTP RRSAPEEPKP LHNPVQHDKE EPVVVSPYSD
660 670 680 690 700
HFELRWGVPA DNGEPIDRYQ IKYCPGVKIS GTWTELENSC NTVEVMETTS
710 720 730 740 750
FEMTQLVGNT YYRIELKAHN AIGYSSPASI IMKTTRGIDV IQVAERQVFS
760 770 780 790 800
SAAIVGIAIG GVLLLLFVVD LLCCITVHMG VMATMCRKAK RSPSEIDDEA
810 820 830 840 850
KLGSGQLVKE PPPSPLPLPP PVKLGGSPMS TPLDEKEPLR TPTGSIKQNS
860 870
TIEFDGRFVH SRSGEIIGKN SAV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 804 | S → R in CAA21826 (PubMed:10731137).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002506 | 737 – 773 | GIDVI…VDLLC → DNPHPSTSGAAPLAQLLVIF TALPTMLLILPPTTHTA in isoform 3. CuratedAdd BLAST | 37 | |
Alternative sequenceiVSP_002508 | 738 – 811 | IDVIQ…LVKEP → ESDSANNNLGTLLYSAGFNS GVGALHKRLFTTTTTTTATS TTTITSITTATTTIITLATT ISITLLSVLASMLA in isoform 2. 1 PublicationAdd BLAST | 74 | |
Alternative sequenceiVSP_002507 | 774 – 873 | Missing in isoform 3. CuratedAdd BLAST | 100 | |
Alternative sequenceiVSP_002509 | 812 – 873 | Missing in isoform 2. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77165 mRNA Translation: AAA28527.1 M77166 mRNA Translation: AAA28528.1 AL033125 Genomic DNA Translation: CAA21825.1 AE014298 Genomic DNA Translation: AAF45925.2 AE014298 Genomic DNA Translation: AAN09118.1 AE014298 Genomic DNA Translation: AAN09119.1 BT014661 mRNA Translation: AAT27285.1 AL033125 Genomic DNA Translation: CAA21826.1 |
PIRi | A41054 B41054 |
RefSeqi | NP_525066.1, NM_080327.3 [P34082-1] NP_726911.1, NM_167004.2 [P34082-3] NP_726912.1, NM_167005.2 [P34082-2] |
UniGenei | Dm.1687 |
Genome annotation databases
EnsemblMetazoai | FBtr0070665; FBpp0070633; FBgn0000635 [P34082-1] FBtr0070666; FBpp0070634; FBgn0000635 [P34082-3] FBtr0070667; FBpp0070635; FBgn0000635 [P34082-2] |
GeneIDi | 31364 |
KEGGi | dme:Dmel_CG3665 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | FAS2_DROME | |
Accessioni | P34082Primary (citable) accession number: P34082 Secondary accession number(s): P34083 Q9W4M6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | March 28, 2018 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |