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P34078

- LTV1_YEAST

UniProt

P34078 - LTV1_YEAST

Protein

Protein LTV1

Gene

LTV1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome.2 Publications

    GO - Biological processi

    1. cellular response to oxidative stress Source: SGD
    2. protein transport Source: UniProtKB-KW
    3. response to osmotic stress Source: SGD
    4. ribosomal small subunit biogenesis Source: SGD
    5. ribosomal small subunit export from nucleus Source: SGD

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31918-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein LTV1
    Alternative name(s):
    Low-temperature viability protein 1
    Gene namesi
    Name:LTV1
    Ordered Locus Names:YKL143W
    ORF Names:YKL2
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL143w.
    SGDiS000001626. LTV1.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Shuttles between the nucleus and the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. late endosome membrane Source: SGD
    3. nucleus Source: SGD
    4. preribosome, small subunit precursor Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 463462Protein LTV1PRO_0000084522Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei288 – 2881Phosphoserine2 Publications
    Modified residuei293 – 2931Phosphoserine2 Publications
    Modified residuei299 – 2991Phosphoserine2 Publications
    Modified residuei303 – 3031Phosphoserine3 Publications

    Post-translational modificationi

    Phosphorylated, leading to its dissociation from the 40S pre-40S ribosome.3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP34078.
    PaxDbiP34078.

    Expressioni

    Gene expression databases

    GenevestigatoriP34078.

    Interactioni

    Subunit structurei

    Associates with the pre-40S ribosomal subunit. Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Interacts directly with GTR1. Interacts with CRM1.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CRM1P308221EBI-10248,EBI-20589
    NUP116Q026301EBI-10248,EBI-11703
    RPS3P057501EBI-10248,EBI-16140

    Protein-protein interaction databases

    BioGridi33993. 113 interactions.
    DIPiDIP-2801N.
    IntActiP34078. 9 interactions.
    MINTiMINT-512519.
    STRINGi4932.YKL143W.

    Structurei

    3D structure databases

    ProteinModelPortaliP34078.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili355 – 462108Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi168 – 17912Nuclear export signalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LTV1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG263248.
    HOGENOMiHOG000172553.
    KOiK14798.
    OMAiWESDATA.
    OrthoDBiEOG7VTDX5.

    Family and domain databases

    InterProiIPR007307. LTV.
    [Graphical view]
    PfamiPF04180. LTV. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34078-1 [UniParc]FASTAAdd to Basket

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    MSKKFSSKNS QRYVVVHRPH DDPSFYDTDA SAHVLVPVSN PNKTSPEADL    50
    RKKDVSSTKP KGRRAHVGEA ALYGINFDDS EYDYTQHLKP IGLDPENSIF 100
    IASKGNEQKV EKKNIEDLFI EPKYRRDEIE KDDALPVFQR GMAKPEYLLH 150
    QQDTTDEIRG FKPDMNPALR EVLEALEDEA YVVNDDVVVE DISKKTQLQG 200
    DNYGEEEKED DIFAQLLGSG EAKDEDEFED EFDEWDIDNV ENFEDENYVK 250
    EMAQFDNIEN LEDLENIDYQ ADVRRFQKDN SILEKHNSDD EFSNAGLDSV 300
    NPSEEEDVLG ELPSIQDKSK TGKKKRKSRQ KKGAMSDVSG FSMSSSAIAR 350
    TETMTVLDDQ YDQIINGYEN YEEELEEDEE QNYQPFDMSA ERSDFESMLD 400
    DFLDNYELES GGRKLAKKDK EIERLKEAAD EVSKGKLSQR RNRERQEKKK 450
    LEKVTNTLSS LKF 463
    Length:463
    Mass (Da):53,390
    Last modified:June 1, 1994 - v2
    Checksum:iF432C239B3B0A68A
    GO

    Sequence cautioni

    The sequence CAA80955.1 differs from that shown. Reason: Frameshift at positions 134 and 145.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25464 Genomic DNA. Translation: CAA80955.1. Frameshift.
    Z28143 Genomic DNA. Translation: CAA81984.1.
    BK006944 Genomic DNA. Translation: DAA09019.1.
    PIRiS37972.
    RefSeqiNP_012779.1. NM_001179709.1.

    Genome annotation databases

    EnsemblFungiiYKL143W; YKL143W; YKL143W.
    GeneIDi853714.
    KEGGisce:YKL143W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25464 Genomic DNA. Translation: CAA80955.1 . Frameshift.
    Z28143 Genomic DNA. Translation: CAA81984.1 .
    BK006944 Genomic DNA. Translation: DAA09019.1 .
    PIRi S37972.
    RefSeqi NP_012779.1. NM_001179709.1.

    3D structure databases

    ProteinModelPortali P34078.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33993. 113 interactions.
    DIPi DIP-2801N.
    IntActi P34078. 9 interactions.
    MINTi MINT-512519.
    STRINGi 4932.YKL143W.

    Proteomic databases

    MaxQBi P34078.
    PaxDbi P34078.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL143W ; YKL143W ; YKL143W .
    GeneIDi 853714.
    KEGGi sce:YKL143W.

    Organism-specific databases

    CYGDi YKL143w.
    SGDi S000001626. LTV1.

    Phylogenomic databases

    eggNOGi NOG263248.
    HOGENOMi HOG000172553.
    KOi K14798.
    OMAi WESDATA.
    OrthoDBi EOG7VTDX5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31918-MONOMER.

    Miscellaneous databases

    NextBioi 974725.
    PROi P34078.

    Gene expression databases

    Genevestigatori P34078.

    Family and domain databases

    InterProi IPR007307. LTV.
    [Graphical view ]
    Pfami PF04180. LTV. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes."
      Abraham P.R., Mulder A., Van'T Riet J., Planta R.J., Raue H.A.
      Yeast 8:227-238(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae."
      Loar J.W., Seiser R.M., Sundberg A.E., Sagerson H.J., Ilias N., Zobel-Thropp P., Craig E.A., Lycan D.E.
      Genetics 168:1877-1889(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit."
      Schaefer T., Maco B., Petfalski E., Tollervey D., Boettcher B., Aebi U., Hurt E.
      Nature 441:651-655(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH THE PRE-40S RIBOSOME, PHOSPHORYLATION.
    8. "A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast."
      Gao M., Kaiser C.A.
      Nat. Cell Biol. 8:657-667(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE GSE COMPLEX, INTERACTION WITH GTR1.
    9. "Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae."
      Seiser R.M., Sundberg A.E., Wollam B.J., Zobel-Thropp P., Baldwin K., Spector M.D., Lycan D.E.
      Genetics 174:679-691(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL, INTERACTION WITH CRM1.
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-293; SER-299 AND SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLTV1_YEAST
    AccessioniPrimary (citable) accession number: P34078
    Secondary accession number(s): D6VX53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 589 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3