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P34078 (LTV1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein LTV1
Alternative name(s):
Low-temperature viability protein 1
Gene names
Name:LTV1
Ordered Locus Names:YKL143W
ORF Names:YKL2
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Ref.6 Ref.9

Subunit structure

Associates with the pre-40S ribosomal subunit. Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Interacts directly with GTR1. Interacts with CRM1. Ref.7 Ref.8 Ref.9

Subcellular location

Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm. Ref.4 Ref.9

Post-translational modification

Phosphorylated, leading to its dissociation from the 40S pre-40S ribosome. Ref.7

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the LTV1 family.

Sequence caution

The sequence CAA80955.1 differs from that shown. Reason: Frameshift at positions 134 and 145.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.12
Chain2 – 463462Protein LTV1
PRO_0000084522

Regions

Coiled coil355 – 462108 Potential
Motif168 – 17912Nuclear export signal

Amino acid modifications

Modified residue21N-acetylserine Ref.12
Modified residue2881Phosphoserine Ref.11
Modified residue2931Phosphoserine Ref.11
Modified residue2991Phosphoserine Ref.11
Modified residue3031Phosphoserine Ref.10 Ref.11

Sequences

Sequence LengthMass (Da)Tools
P34078 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: F432C239B3B0A68A

FASTA46353,390
        10         20         30         40         50         60 
MSKKFSSKNS QRYVVVHRPH DDPSFYDTDA SAHVLVPVSN PNKTSPEADL RKKDVSSTKP 

        70         80         90        100        110        120 
KGRRAHVGEA ALYGINFDDS EYDYTQHLKP IGLDPENSIF IASKGNEQKV EKKNIEDLFI 

       130        140        150        160        170        180 
EPKYRRDEIE KDDALPVFQR GMAKPEYLLH QQDTTDEIRG FKPDMNPALR EVLEALEDEA 

       190        200        210        220        230        240 
YVVNDDVVVE DISKKTQLQG DNYGEEEKED DIFAQLLGSG EAKDEDEFED EFDEWDIDNV 

       250        260        270        280        290        300 
ENFEDENYVK EMAQFDNIEN LEDLENIDYQ ADVRRFQKDN SILEKHNSDD EFSNAGLDSV 

       310        320        330        340        350        360 
NPSEEEDVLG ELPSIQDKSK TGKKKRKSRQ KKGAMSDVSG FSMSSSAIAR TETMTVLDDQ 

       370        380        390        400        410        420 
YDQIINGYEN YEEELEEDEE QNYQPFDMSA ERSDFESMLD DFLDNYELES GGRKLAKKDK 

       430        440        450        460 
EIERLKEAAD EVSKGKLSQR RNRERQEKKK LEKVTNTLSS LKF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes."
Abraham P.R., Mulder A., Van'T Riet J., Planta R.J., Raue H.A.
Yeast 8:227-238(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete DNA sequence of yeast chromosome XI."
Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. expand/collapse author list , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae."
Loar J.W., Seiser R.M., Sundberg A.E., Sagerson H.J., Ilias N., Zobel-Thropp P., Craig E.A., Lycan D.E.
Genetics 168:1877-1889(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit."
Schaefer T., Maco B., Petfalski E., Tollervey D., Boettcher B., Aebi U., Hurt E.
Nature 441:651-655(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH THE PRE-40S RIBOSOME, PHOSPHORYLATION.
[8]"A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast."
Gao M., Kaiser C.A.
Nat. Cell Biol. 8:657-667(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE GSE COMPLEX, INTERACTION WITH GTR1.
[9]"Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae."
Seiser R.M., Sundberg A.E., Wollam B.J., Zobel-Thropp P., Baldwin K., Spector M.D., Lycan D.E.
Genetics 174:679-691(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL, INTERACTION WITH CRM1.
[10]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-293; SER-299 AND SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z25464 Genomic DNA. Translation: CAA80955.1. Frameshift.
Z28143 Genomic DNA. Translation: CAA81984.1.
BK006944 Genomic DNA. Translation: DAA09019.1.
PIRS37972.
RefSeqNP_012779.1. NM_001179709.1.

3D structure databases

ProteinModelPortalP34078.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33993. 113 interactions.
DIPDIP-2801N.
IntActP34078. 9 interactions.
MINTMINT-512519.
STRING4932.YKL143W.

Proteomic databases

MaxQBP34078.
PaxDbP34078.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYKL143W; YKL143W; YKL143W.
GeneID853714.
KEGGsce:YKL143W.

Organism-specific databases

CYGDYKL143w.
SGDS000001626. LTV1.

Phylogenomic databases

eggNOGNOG263248.
HOGENOMHOG000172553.
KOK14798.
OMAWESDATA.
OrthoDBEOG7VTDX5.

Enzyme and pathway databases

BioCycYEAST:G3O-31918-MONOMER.

Gene expression databases

GenevestigatorP34078.

Family and domain databases

InterProIPR007307. LTV.
[Graphical view]
PfamPF04180. LTV. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio974725.
PROP34078.

Entry information

Entry nameLTV1_YEAST
AccessionPrimary (citable) accession number: P34078
Secondary accession number(s): D6VX53
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families