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Protein

Protein LTV1

Gene

LTV1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome.2 Publications

GO - Biological processi

  • ATP export Source: SGD
  • cellular response to oxidative stress Source: SGD
  • protein transport Source: UniProtKB-KW
  • response to osmotic stress Source: SGD
  • ribosomal small subunit biogenesis Source: SGD
  • ribosomal small subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LTV1
Alternative name(s):
Low-temperature viability protein 1
Gene namesi
Name:LTV1
Ordered Locus Names:YKL143W
ORF Names:YKL2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL143W.
SGDiS000001626. LTV1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • late endosome membrane Source: SGD
  • nucleus Source: SGD
  • preribosome, small subunit precursor Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000845222 – 463Protein LTV1Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated, leading to its dissociation from the 40S pre-40S ribosome.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP34078.
PRIDEiP34078.

PTM databases

iPTMnetiP34078.

Interactioni

Subunit structurei

Associates with the pre-40S ribosomal subunit. Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Interacts directly with GTR1. Interacts with CRM1.3 Publications

Protein-protein interaction databases

BioGridi33993. 120 interactors.
DIPiDIP-2801N.
IntActiP34078. 13 interactors.
MINTiMINT-512519.

Structurei

3D structure databases

ProteinModelPortaliP34078.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 462Sequence analysisAdd BLAST108

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi168 – 179Nuclear export signalAdd BLAST12

Sequence similaritiesi

Belongs to the LTV1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000172553.
InParanoidiP34078.
KOiK14798.
OMAiQHFTLVH.
OrthoDBiEOG092C2XSD.

Family and domain databases

InterProiIPR007307. LTV.
[Graphical view]
PfamiPF04180. LTV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34078-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKFSSKNS QRYVVVHRPH DDPSFYDTDA SAHVLVPVSN PNKTSPEADL
60 70 80 90 100
RKKDVSSTKP KGRRAHVGEA ALYGINFDDS EYDYTQHLKP IGLDPENSIF
110 120 130 140 150
IASKGNEQKV EKKNIEDLFI EPKYRRDEIE KDDALPVFQR GMAKPEYLLH
160 170 180 190 200
QQDTTDEIRG FKPDMNPALR EVLEALEDEA YVVNDDVVVE DISKKTQLQG
210 220 230 240 250
DNYGEEEKED DIFAQLLGSG EAKDEDEFED EFDEWDIDNV ENFEDENYVK
260 270 280 290 300
EMAQFDNIEN LEDLENIDYQ ADVRRFQKDN SILEKHNSDD EFSNAGLDSV
310 320 330 340 350
NPSEEEDVLG ELPSIQDKSK TGKKKRKSRQ KKGAMSDVSG FSMSSSAIAR
360 370 380 390 400
TETMTVLDDQ YDQIINGYEN YEEELEEDEE QNYQPFDMSA ERSDFESMLD
410 420 430 440 450
DFLDNYELES GGRKLAKKDK EIERLKEAAD EVSKGKLSQR RNRERQEKKK
460
LEKVTNTLSS LKF
Length:463
Mass (Da):53,390
Last modified:June 1, 1994 - v2
Checksum:iF432C239B3B0A68A
GO

Sequence cautioni

The sequence CAA80955 differs from that shown. Reason: Frameshift at positions 134 and 145.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25464 Genomic DNA. Translation: CAA80955.1. Frameshift.
Z28143 Genomic DNA. Translation: CAA81984.1.
BK006944 Genomic DNA. Translation: DAA09019.1.
PIRiS37972.
RefSeqiNP_012779.1. NM_001179709.1.

Genome annotation databases

EnsemblFungiiYKL143W; YKL143W; YKL143W.
GeneIDi853714.
KEGGisce:YKL143W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25464 Genomic DNA. Translation: CAA80955.1. Frameshift.
Z28143 Genomic DNA. Translation: CAA81984.1.
BK006944 Genomic DNA. Translation: DAA09019.1.
PIRiS37972.
RefSeqiNP_012779.1. NM_001179709.1.

3D structure databases

ProteinModelPortaliP34078.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33993. 120 interactors.
DIPiDIP-2801N.
IntActiP34078. 13 interactors.
MINTiMINT-512519.

PTM databases

iPTMnetiP34078.

Proteomic databases

MaxQBiP34078.
PRIDEiP34078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL143W; YKL143W; YKL143W.
GeneIDi853714.
KEGGisce:YKL143W.

Organism-specific databases

EuPathDBiFungiDB:YKL143W.
SGDiS000001626. LTV1.

Phylogenomic databases

HOGENOMiHOG000172553.
InParanoidiP34078.
KOiK14798.
OMAiQHFTLVH.
OrthoDBiEOG092C2XSD.

Enzyme and pathway databases

BioCyciYEAST:G3O-31918-MONOMER.

Miscellaneous databases

PROiP34078.

Family and domain databases

InterProiIPR007307. LTV.
[Graphical view]
PfamiPF04180. LTV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLTV1_YEAST
AccessioniPrimary (citable) accession number: P34078
Secondary accession number(s): D6VX53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.