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P34078

- LTV1_YEAST

UniProt

P34078 - LTV1_YEAST

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Protein

Protein LTV1

Gene
LTV1, YKL143W, YKL2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome.2 Publications

GO - Biological processi

  1. cellular response to oxidative stress Source: SGD
  2. protein transport Source: UniProtKB-KW
  3. response to osmotic stress Source: SGD
  4. ribosomal small subunit biogenesis Source: SGD
  5. ribosomal small subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LTV1
Alternative name(s):
Low-temperature viability protein 1
Gene namesi
Name:LTV1
Ordered Locus Names:YKL143W
ORF Names:YKL2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL143w.
SGDiS000001626. LTV1.

Subcellular locationi

Nucleus. Cytoplasm
Note: Shuttles between the nucleus and the cytoplasm.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. late endosome membrane Source: SGD
  3. nucleus Source: SGD
  4. preribosome, small subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 463462Protein LTV1PRO_0000084522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei288 – 2881Phosphoserine1 Publication
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei299 – 2991Phosphoserine1 Publication
Modified residuei303 – 3031Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated, leading to its dissociation from the 40S pre-40S ribosome.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP34078.
PaxDbiP34078.

Expressioni

Gene expression databases

GenevestigatoriP34078.

Interactioni

Subunit structurei

Associates with the pre-40S ribosomal subunit. Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Interacts directly with GTR1. Interacts with CRM1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CRM1P308221EBI-10248,EBI-20589
NUP116Q026301EBI-10248,EBI-11703
RPS3P057501EBI-10248,EBI-16140

Protein-protein interaction databases

BioGridi33993. 113 interactions.
DIPiDIP-2801N.
IntActiP34078. 9 interactions.
MINTiMINT-512519.
STRINGi4932.YKL143W.

Structurei

3D structure databases

ProteinModelPortaliP34078.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili355 – 462108 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi168 – 17912Nuclear export signalAdd
BLAST

Sequence similaritiesi

Belongs to the LTV1 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG263248.
HOGENOMiHOG000172553.
KOiK14798.
OMAiWESDATA.
OrthoDBiEOG7VTDX5.

Family and domain databases

InterProiIPR007307. LTV.
[Graphical view]
PfamiPF04180. LTV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34078-1 [UniParc]FASTAAdd to Basket

« Hide

MSKKFSSKNS QRYVVVHRPH DDPSFYDTDA SAHVLVPVSN PNKTSPEADL    50
RKKDVSSTKP KGRRAHVGEA ALYGINFDDS EYDYTQHLKP IGLDPENSIF 100
IASKGNEQKV EKKNIEDLFI EPKYRRDEIE KDDALPVFQR GMAKPEYLLH 150
QQDTTDEIRG FKPDMNPALR EVLEALEDEA YVVNDDVVVE DISKKTQLQG 200
DNYGEEEKED DIFAQLLGSG EAKDEDEFED EFDEWDIDNV ENFEDENYVK 250
EMAQFDNIEN LEDLENIDYQ ADVRRFQKDN SILEKHNSDD EFSNAGLDSV 300
NPSEEEDVLG ELPSIQDKSK TGKKKRKSRQ KKGAMSDVSG FSMSSSAIAR 350
TETMTVLDDQ YDQIINGYEN YEEELEEDEE QNYQPFDMSA ERSDFESMLD 400
DFLDNYELES GGRKLAKKDK EIERLKEAAD EVSKGKLSQR RNRERQEKKK 450
LEKVTNTLSS LKF 463
Length:463
Mass (Da):53,390
Last modified:June 1, 1994 - v2
Checksum:iF432C239B3B0A68A
GO

Sequence cautioni

The sequence CAA80955.1 differs from that shown. Reason: Frameshift at positions 134 and 145.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25464 Genomic DNA. Translation: CAA80955.1. Frameshift.
Z28143 Genomic DNA. Translation: CAA81984.1.
BK006944 Genomic DNA. Translation: DAA09019.1.
PIRiS37972.
RefSeqiNP_012779.1. NM_001179709.1.

Genome annotation databases

EnsemblFungiiYKL143W; YKL143W; YKL143W.
GeneIDi853714.
KEGGisce:YKL143W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25464 Genomic DNA. Translation: CAA80955.1 . Frameshift.
Z28143 Genomic DNA. Translation: CAA81984.1 .
BK006944 Genomic DNA. Translation: DAA09019.1 .
PIRi S37972.
RefSeqi NP_012779.1. NM_001179709.1.

3D structure databases

ProteinModelPortali P34078.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33993. 113 interactions.
DIPi DIP-2801N.
IntActi P34078. 9 interactions.
MINTi MINT-512519.
STRINGi 4932.YKL143W.

Proteomic databases

MaxQBi P34078.
PaxDbi P34078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL143W ; YKL143W ; YKL143W .
GeneIDi 853714.
KEGGi sce:YKL143W.

Organism-specific databases

CYGDi YKL143w.
SGDi S000001626. LTV1.

Phylogenomic databases

eggNOGi NOG263248.
HOGENOMi HOG000172553.
KOi K14798.
OMAi WESDATA.
OrthoDBi EOG7VTDX5.

Enzyme and pathway databases

BioCyci YEAST:G3O-31918-MONOMER.

Miscellaneous databases

NextBioi 974725.
PROi P34078.

Gene expression databases

Genevestigatori P34078.

Family and domain databases

InterProi IPR007307. LTV.
[Graphical view ]
Pfami PF04180. LTV. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes."
    Abraham P.R., Mulder A., Van'T Riet J., Planta R.J., Raue H.A.
    Yeast 8:227-238(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae."
    Loar J.W., Seiser R.M., Sundberg A.E., Sagerson H.J., Ilias N., Zobel-Thropp P., Craig E.A., Lycan D.E.
    Genetics 168:1877-1889(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit."
    Schaefer T., Maco B., Petfalski E., Tollervey D., Boettcher B., Aebi U., Hurt E.
    Nature 441:651-655(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH THE PRE-40S RIBOSOME, PHOSPHORYLATION.
  8. "A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast."
    Gao M., Kaiser C.A.
    Nat. Cell Biol. 8:657-667(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE GSE COMPLEX, INTERACTION WITH GTR1.
  9. "Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae."
    Seiser R.M., Sundberg A.E., Wollam B.J., Zobel-Thropp P., Baldwin K., Spector M.D., Lycan D.E.
    Genetics 174:679-691(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL, INTERACTION WITH CRM1.
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-293; SER-299 AND SER-303, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLTV1_YEAST
AccessioniPrimary (citable) accession number: P34078
Secondary accession number(s): D6VX53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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