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Protein

Negative regulator of RAS-cAMP pathway

Gene

MKS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of Ras-cAMP pathway. Involved in transcriptional regulation of galactose-inducible genes.

GO - Biological processi

  • mitochondria-nucleus signaling pathway Source: SGD
  • negative regulation of transcription by RNA polymerase II Source: SGD
  • regulation of nitrogen utilization Source: SGD
  • regulation of pseudohyphal growth Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33105-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of RAS-cAMP pathway
Gene namesi
Name:MKS1
Synonyms:LYS80
Ordered Locus Names:YNL076W
ORF Names:N2344, N2347
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL076W
SGDiS000005020 MKS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964941 – 584Negative regulator of RAS-cAMP pathwayAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphothreonineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei518Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34072
PaxDbiP34072
PRIDEiP34072

PTM databases

iPTMnetiP34072

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35747, 374 interactors
DIPiDIP-6677N
IntActiP34072, 23 interactors
MINTiP34072
STRINGi4932.YNL076W

Structurei

3D structure databases

ProteinModelPortaliP34072
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000113596
InParanoidiP34072
OMAiMDIPSKN
OrthoDBiEOG092C1MC8

Family and domain databases

InterProiView protein in InterPro
IPR013860 DUF1752_fun
PfamiView protein in Pfam
PF08550 DUF1752, 1 hit

Sequencei

Sequence statusi: Complete.

P34072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREAFDVPN IGTNKFLKVT PNLFTPERLN LFDDVELYLT LIKASKCVEQ
60 70 80 90 100
GERLHNISWR ILNKAVLKEH NINRSKKRDG VKNIYYVLNP NNKQPIKPKQ
110 120 130 140 150
AAVKQPPLQK ANLPPTTAKQ NVLTRPMTSP AIAQGAHDRS LDNPNSTNND
160 170 180 190 200
VKNDVAPNRQ FSKSTTSGLF SNFADKYQKM KNVNHVANKE EPQTIITGFD
210 220 230 240 250
TSTVITKKPL QSRRSRSPFQ HIGDMNMNCI DNETSKSTSP TLENMGSRKS
260 270 280 290 300
SFPQKESLFG RPRSYKNDQN GQLSLSKTSS RKGKNKIFFS SEDEDSDWDS
310 320 330 340 350
VSNDSEFYAD EDDEEYDDYN EEEADQYYRR QWDKLLFAKN QQNLDSTKSS
360 370 380 390 400
VSSANTINSN TSHDPVRKSL LSGLFLSEAN SNSNNHNTAH SEYASKHVSP
410 420 430 440 450
TPQSSHSNIG PQPQQNPPSA NGIKQQKPSL KTSNVTALAS LSPPQPSNNE
460 470 480 490 500
RLSMDIQKDF KTDNESNHLY ESNAPLTAQT ILPTALSTHM FLPNNIHQQR
510 520 530 540 550
MAIATGSNTR HRFSRRQSMD IPSKNRNTGF LKTRMEISEE EKMVRTISRL
560 570 580
DNTSIANSNG NGNDDTSNQR TEALGRKTSN GGRI
Length:584
Mass (Da):65,643
Last modified:February 1, 1996 - v2
Checksum:i79B0EE5F8DDE0145
GO

Sequence cautioni

The sequence CAA60181 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA Translation: CAA60181.1 Sequence problems.
X86470 Genomic DNA Translation: CAA60182.1
Z71352 Genomic DNA Translation: CAA95950.1
D13715 Genomic DNA Translation: BAA02868.1
BK006947 Genomic DNA Translation: DAA10469.1
PIRiS53902
RefSeqiNP_014323.1, NM_001182914.1

Genome annotation databases

EnsemblFungiiYNL076W; YNL076W; YNL076W
GeneIDi855648
KEGGisce:YNL076W

Similar proteinsi

Entry informationi

Entry nameiMKS1_YEAST
AccessioniPrimary (citable) accession number: P34072
Secondary accession number(s): D6W1A3, Q02533
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health