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Protein

Enterotoxin type C-2

Gene

entC2

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Zinc1
Metal bindingi110Zinc1
Metal bindingi145Zinc1
Metal bindingi149Zinc1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type C-2
Alternative name(s):
SEC2
Gene namesi
Name:entC2
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2141. Sta a SEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000003560828 – 266Enterotoxin type C-2Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 137

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP34071.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2009.

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 37Combined sources3
Helixi41 – 43Combined sources3
Helixi49 – 52Combined sources4
Turni53 – 55Combined sources3
Beta strandi60 – 65Combined sources6
Beta strandi75 – 79Combined sources5
Turni83 – 85Combined sources3
Beta strandi89 – 94Combined sources6
Helixi98 – 104Combined sources7
Beta strandi109 – 113Combined sources5
Beta strandi127 – 133Combined sources7
Beta strandi135 – 139Combined sources5
Beta strandi142 – 145Combined sources4
Helixi151 – 153Combined sources3
Beta strandi156 – 166Combined sources11
Beta strandi168 – 182Combined sources15
Helixi183 – 198Combined sources16
Beta strandi209 – 216Combined sources8
Beta strandi222 – 226Combined sources5
Beta strandi231 – 233Combined sources3
Helixi237 – 241Combined sources5
Helixi242 – 244Combined sources3
Beta strandi249 – 251Combined sources3
Turni252 – 254Combined sources3
Beta strandi256 – 262Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CQVX-ray2.06A28-266[»]
1I4PX-ray2.00A28-266[»]
1I4QX-ray2.20A28-266[»]
1I4RX-ray2.10A28-266[»]
1I4XX-ray2.40A28-266[»]
1SE2X-ray2.70A28-266[»]
1STEX-ray2.00A28-266[»]
1UNSX-ray2.00A28-266[»]
ProteinModelPortaliP34071.
SMRiP34071.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34071.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSRFISCV ILIFALILVL FTPNVLAESQ PDPTPDELHK SSEFTGTMGN
60 70 80 90 100
MKYLYDDHYV SATKVMSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEDL
110 120 130 140 150
AKKYKDEVVD VYGSNYYVNC YFSSKDNVGK VTGGKTCMYG GITKHEGNHF
160 170 180 190 200
DNGNLQNVLI RVYENKRNTI SFEVQTDKKS VTAQELDIKA RNFLINKKNL
210 220 230 240 250
YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY LMMYNDNKTV
260
DSKSVKIEVH LTTKNG
Length:266
Mass (Da):30,604
Last modified:February 1, 1994 - v1
Checksum:i8407FB18536FAC08
GO

Sequence databases

PIRiA60114.
RefSeqiWP_001043552.1. NZ_LWMF01000003.1.

Cross-referencesi

Sequence databases

PIRiA60114.
RefSeqiWP_001043552.1. NZ_LWMF01000003.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CQVX-ray2.06A28-266[»]
1I4PX-ray2.00A28-266[»]
1I4QX-ray2.20A28-266[»]
1I4RX-ray2.10A28-266[»]
1I4XX-ray2.40A28-266[»]
1SE2X-ray2.70A28-266[»]
1STEX-ray2.00A28-266[»]
1UNSX-ray2.00A28-266[»]
ProteinModelPortaliP34071.
SMRiP34071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2009.

Protein family/group databases

Allergomei2141. Sta a SEC.

Proteomic databases

PaxDbiP34071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP34071.
PROiP34071.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiENTC2_STAAU
AccessioniPrimary (citable) accession number: P34071
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.