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P34065 (PSB5_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-5

EC=3.4.25.1
Alternative name(s):
Macropain chain 1
Multicatalytic endopeptidase complex chain 1
Proteasome chain 1
Proteasome subunit C1
Gene names
Name:PSMB5
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length256 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide‹1 – 55›55Removed in mature form By similarity
PRO_0000026603
Chain56 – 256201Proteasome subunit beta type-5
PRO_0000026604

Sites

Active site561Nucleophile By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P34065 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: ED467B1C925D5186

FASTA25627,045
        10         20         30         40         50         60 
CNMALADIVR LPPASEAPFA PLGAPRDLSG PPSKLAVRPW GGADLPGPGL QLLHGTTTLA 

        70         80         90        100        110        120 
FKFAHGVVVA VDSRATAGSY IASQTVQKVI EINPSLLGTM AGGAADCSFW ERLLARQCRV 

       130        140        150        160        170        180 
YELRNKEPIS VAAASKLLAN MVYQYKGMGL SMGTMICGWD KRGPGLYYVD SEGTRIPGEA 

       190        200        210        220        230        240 
FAVGSGSSYA YGVLDGGRRP DMATDEALEL ARRAIFQAAR RDAYSGGSVT VYHVGPRGWR 

       250 
RVSSHDVAGL HDGYGG 

« Hide

References

[1]"Expression of proteasome C1 gene in intercostal muscle of chick embryo."
Hirosaki Y., Sawada K., Aoyama H.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Primary structure of the smallest subunit of chicken liver proteasome responsible for its chymotrypsin-like activity."
Shiratsuch A., Sato S.
Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-256.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB001935 mRNA. Translation: BAA19471.1.
X57210 mRNA. Translation: CAA40494.1.
PIRS30539.
RefSeqNP_001264655.1. NM_001277726.1.
UniGeneGga.4313.
Gga.46493.
Gga.55806.

3D structure databases

ProteinModelPortalP34065.
SMRP34065. Positions 56-256.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.P01.

Proteomic databases

PRIDEP34065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396003.
KEGGgga:396003.

Organism-specific databases

CTD5693.

Phylogenomic databases

HOVERGENHBG108297.
KOK02737.
PhylomeDBP34065.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSPR00141. PROTEASOME.
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB5_CHICK
AccessionPrimary (citable) accession number: P34065
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 15, 1998
Last modified: June 11, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries