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P34065

- PSB5_CHICK

UniProt

P34065 - PSB5_CHICK

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Protein
Proteasome subunit beta type-5
Gene
PSMB5
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561Nucleophile By similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.P01.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-5 (EC:3.4.25.1)
Alternative name(s):
Macropain chain 1
Multicatalytic endopeptidase complex chain 1
Proteasome chain 1
Proteasome subunit C1
Gene namesi
Name:PSMB5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei‹1 – 55›55Removed in mature form By similarity
PRO_0000026603Add
BLAST
Chaini56 – 256201Proteasome subunit beta type-5
PRO_0000026604Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PRIDEiP34065.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Structurei

3D structure databases

ProteinModelPortaliP34065.
SMRiP34065. Positions 56-256.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

HOVERGENiHBG108297.
KOiK02737.
PhylomeDBiP34065.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34065-1 [UniParc]FASTAAdd to Basket

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CNMALADIVR LPPASEAPFA PLGAPRDLSG PPSKLAVRPW GGADLPGPGL    50
QLLHGTTTLA FKFAHGVVVA VDSRATAGSY IASQTVQKVI EINPSLLGTM 100
AGGAADCSFW ERLLARQCRV YELRNKEPIS VAAASKLLAN MVYQYKGMGL 150
SMGTMICGWD KRGPGLYYVD SEGTRIPGEA FAVGSGSSYA YGVLDGGRRP 200
DMATDEALEL ARRAIFQAAR RDAYSGGSVT VYHVGPRGWR RVSSHDVAGL 250
HDGYGG 256
Length:256
Mass (Da):27,045
Last modified:July 15, 1998 - v2
Checksum:iED467B1C925D5186
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001935 mRNA. Translation: BAA19471.1.
X57210 mRNA. Translation: CAA40494.1.
PIRiS30539.
RefSeqiNP_001264655.1. NM_001277726.1.
UniGeneiGga.4313.
Gga.46493.
Gga.55806.

Genome annotation databases

GeneIDi396003.
KEGGigga:396003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001935 mRNA. Translation: BAA19471.1 .
X57210 mRNA. Translation: CAA40494.1 .
PIRi S30539.
RefSeqi NP_001264655.1. NM_001277726.1.
UniGenei Gga.4313.
Gga.46493.
Gga.55806.

3D structure databases

ProteinModelPortali P34065.
SMRi P34065. Positions 56-256.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.P01.

Proteomic databases

PRIDEi P34065.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396003.
KEGGi gga:396003.

Organism-specific databases

CTDi 5693.

Phylogenomic databases

HOVERGENi HBG108297.
KOi K02737.
PhylomeDBi P34065.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression of proteasome C1 gene in intercostal muscle of chick embryo."
    Hirosaki Y., Sawada K., Aoyama H.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure of the smallest subunit of chicken liver proteasome responsible for its chymotrypsin-like activity."
    Shiratsuch A., Sato S.
    Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-256.
    Tissue: Liver.

Entry informationi

Entry nameiPSB5_CHICK
AccessioniPrimary (citable) accession number: P34065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 15, 1998
Last modified: June 11, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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