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P34065

- PSB5_CHICK

UniProt

P34065 - PSB5_CHICK

Protein

Proteasome subunit beta type-5

Gene

PSMB5

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561NucleophileBy similarity

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. proteolysis involved in cellular protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Protein family/group databases

    MEROPSiT01.P01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit beta type-5 (EC:3.4.25.1)
    Alternative name(s):
    Macropain chain 1
    Multicatalytic endopeptidase complex chain 1
    Proteasome chain 1
    Proteasome subunit C1
    Gene namesi
    Name:PSMB5
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei‹1 – 55›55Removed in mature formBy similarityPRO_0000026603Add
    BLAST
    Chaini56 – 256201Proteasome subunit beta type-5PRO_0000026604Add
    BLAST

    Keywords - PTMi

    Zymogen

    Proteomic databases

    PRIDEiP34065.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP34065.
    SMRiP34065. Positions 56-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1B family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG108297.
    KOiK02737.
    PhylomeDBiP34065.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000243. Pept_T1A_subB.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    [Graphical view]
    PRINTSiPR00141. PROTEASOME.
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34065-1 [UniParc]FASTAAdd to Basket

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    CNMALADIVR LPPASEAPFA PLGAPRDLSG PPSKLAVRPW GGADLPGPGL    50
    QLLHGTTTLA FKFAHGVVVA VDSRATAGSY IASQTVQKVI EINPSLLGTM 100
    AGGAADCSFW ERLLARQCRV YELRNKEPIS VAAASKLLAN MVYQYKGMGL 150
    SMGTMICGWD KRGPGLYYVD SEGTRIPGEA FAVGSGSSYA YGVLDGGRRP 200
    DMATDEALEL ARRAIFQAAR RDAYSGGSVT VYHVGPRGWR RVSSHDVAGL 250
    HDGYGG 256
    Length:256
    Mass (Da):27,045
    Last modified:July 15, 1998 - v2
    Checksum:iED467B1C925D5186
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001935 mRNA. Translation: BAA19471.1.
    X57210 mRNA. Translation: CAA40494.1.
    PIRiS30539.
    RefSeqiNP_001264655.1. NM_001277726.1.
    UniGeneiGga.4313.
    Gga.46493.
    Gga.55806.

    Genome annotation databases

    GeneIDi396003.
    KEGGigga:396003.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB001935 mRNA. Translation: BAA19471.1 .
    X57210 mRNA. Translation: CAA40494.1 .
    PIRi S30539.
    RefSeqi NP_001264655.1. NM_001277726.1.
    UniGenei Gga.4313.
    Gga.46493.
    Gga.55806.

    3D structure databases

    ProteinModelPortali P34065.
    SMRi P34065. Positions 56-256.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi T01.P01.

    Proteomic databases

    PRIDEi P34065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396003.
    KEGGi gga:396003.

    Organism-specific databases

    CTDi 5693.

    Phylogenomic databases

    HOVERGENi HBG108297.
    KOi K02737.
    PhylomeDBi P34065.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000243. Pept_T1A_subB.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    [Graphical view ]
    PRINTSi PR00141. PROTEASOME.
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of proteasome C1 gene in intercostal muscle of chick embryo."
      Hirosaki Y., Sawada K., Aoyama H.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Primary structure of the smallest subunit of chicken liver proteasome responsible for its chymotrypsin-like activity."
      Shiratsuch A., Sato S.
      Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-256.
      Tissue: Liver.

    Entry informationi

    Entry nameiPSB5_CHICK
    AccessioniPrimary (citable) accession number: P34065
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3