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P34064 (PSA5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-5

EC=3.4.25.1
Alternative name(s):
Macropain zeta chain
Multicatalytic endopeptidase complex zeta chain
Proteasome zeta chain
Gene names
Name:Psma5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly By similarity.

Subcellular location

Cytoplasm. Nucleus.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Proteasome subunit alpha type-5
PRO_0000124119

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue161Phosphoserine By similarity
Modified residue551Phosphothreonine By similarity
Modified residue561Phosphoserine By similarity
Glycosylation1981O-linked (GlcNAc) By similarity

Sequences

Sequence LengthMass (Da)Tools
P34064 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 97491D1974D1483D

FASTA24126,391
        10         20         30         40         50         60 
MFLTRSEYDR GVNTFSPEGR LFQVEYAIEG HKLGSTAIGI QTSEGVCLAV EKRITSPLME 

        70         80         90        100        110        120 
PSSIEKIVEI DAHIGCAMSG LIADAKTLID KARVETQNHW FTYNETMTVE SVTQAVSNLA 

       130        140        150        160        170        180 
LQFGEEDADP GAMSRPFGVA LLFGGVDEKG PQLFHMDPSG TFVQCDARAI GSASEGAQSS 

       190        200        210        220        230        240 
LQEVYHKSTT LKEAIKSSLI ILKQVMEEKL NATNIELATV QPGQNFHMFT KEELEEVIKD 


I 

« Hide

References

[1]"Molecular cloning of cDNAs for rat proteasomes: deduced primary structures of four other subunits."
Tamura T., Shimbara N., Aki M., Ishida N., Bey F., Scherrer K., Tanaka K., Ichihara A.
J. Biochem. 112:530-534(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10756 mRNA. Translation: BAA01588.1.
PIRJX0229.
RefSeqNP_058978.1. NM_017282.1.
UniGeneRn.1276.

3D structure databases

ProteinModelPortalP34064.
SMRP34064. Positions 8-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248293. 1 interaction.
IntActP34064. 1 interaction.
STRING10116.ENSRNOP00000026928.

Protein family/group databases

MEROPST01.975.

Proteomic databases

PaxDbP34064.
PRIDEP34064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29672.
KEGGrno:29672.
UCSCRGD:61848. rat.

Organism-specific databases

CTD5686.
RGD61848. Psma5.

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000091085.
HOVERGENHBG003005.
InParanoidP34064.
KOK02729.
PhylomeDBP34064.

Gene expression databases

GenevestigatorP34064.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609999.
PROP34064.

Entry information

Entry namePSA5_RAT
AccessionPrimary (citable) accession number: P34064
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries