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P34064

- PSA5_RAT

UniProt

P34064 - PSA5_RAT

Protein

Proteasome subunit alpha type-5

Gene

Psma5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Protein family/group databases

    MEROPSiT01.975.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-5 (EC:3.4.25.1)
    Alternative name(s):
    Macropain zeta chain
    Multicatalytic endopeptidase complex zeta chain
    Proteasome zeta chain
    Gene namesi
    Name:Psma5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi61848. Psma5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: UniProtKB
    4. proteasome core complex, alpha-subunit complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Proteasome subunit alpha type-5PRO_0000124119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei16 – 161PhosphoserineBy similarity
    Modified residuei55 – 551PhosphothreonineBy similarity
    Modified residuei56 – 561PhosphoserineBy similarity
    Glycosylationi198 – 1981O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP34064.
    PRIDEiP34064.

    Expressioni

    Gene expression databases

    GenevestigatoriP34064.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly By similarity.By similarity

    Protein-protein interaction databases

    BioGridi248293. 1 interaction.
    IntActiP34064. 1 interaction.
    STRINGi10116.ENSRNOP00000026928.

    Structurei

    3D structure databases

    ProteinModelPortaliP34064.
    SMRiP34064. Positions 8-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    HOGENOMiHOG000091085.
    HOVERGENiHBG003005.
    InParanoidiP34064.
    KOiK02729.
    PhylomeDBiP34064.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34064-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLTRSEYDR GVNTFSPEGR LFQVEYAIEG HKLGSTAIGI QTSEGVCLAV    50
    EKRITSPLME PSSIEKIVEI DAHIGCAMSG LIADAKTLID KARVETQNHW 100
    FTYNETMTVE SVTQAVSNLA LQFGEEDADP GAMSRPFGVA LLFGGVDEKG 150
    PQLFHMDPSG TFVQCDARAI GSASEGAQSS LQEVYHKSTT LKEAIKSSLI 200
    ILKQVMEEKL NATNIELATV QPGQNFHMFT KEELEEVIKD I 241
    Length:241
    Mass (Da):26,391
    Last modified:February 1, 1994 - v1
    Checksum:i97491D1974D1483D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10756 mRNA. Translation: BAA01588.1.
    PIRiJX0229.
    RefSeqiNP_058978.1. NM_017282.1.
    UniGeneiRn.1276.

    Genome annotation databases

    GeneIDi29672.
    KEGGirno:29672.
    UCSCiRGD:61848. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10756 mRNA. Translation: BAA01588.1 .
    PIRi JX0229.
    RefSeqi NP_058978.1. NM_017282.1.
    UniGenei Rn.1276.

    3D structure databases

    ProteinModelPortali P34064.
    SMRi P34064. Positions 8-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248293. 1 interaction.
    IntActi P34064. 1 interaction.
    STRINGi 10116.ENSRNOP00000026928.

    Protein family/group databases

    MEROPSi T01.975.

    Proteomic databases

    PaxDbi P34064.
    PRIDEi P34064.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29672.
    KEGGi rno:29672.
    UCSCi RGD:61848. rat.

    Organism-specific databases

    CTDi 5686.
    RGDi 61848. Psma5.

    Phylogenomic databases

    eggNOGi COG0638.
    HOGENOMi HOG000091085.
    HOVERGENi HBG003005.
    InParanoidi P34064.
    KOi K02729.
    PhylomeDBi P34064.

    Miscellaneous databases

    NextBioi 609999.
    PROi P34064.

    Gene expression databases

    Genevestigatori P34064.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNAs for rat proteasomes: deduced primary structures of four other subunits."
      Tamura T., Shimbara N., Aki M., Ishida N., Bey F., Scherrer K., Tanaka K., Ichihara A.
      J. Biochem. 112:530-534(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPSA5_RAT
    AccessioniPrimary (citable) accession number: P34064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3