ID   CP2BX_CAVPO             Reviewed;          20 AA.
AC   P34033;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   28-JUN-2023, entry version 89.
DE   RecName: Full=Cytochrome P450IIB;
DE            EC=1.14.14.1;
DE   Flags: Fragment;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   STRAIN=Hartley; TISSUE=Liver;
RX   PubMed=2173574; DOI=10.1016/0006-291x(90)90717-2;
RA   Narimatsu S., Akutsu Y., Matsunaga T., Watanabe K., Yamamoto I.,
RA   Yoshimura H.;
RT   "Purification of a cytochrome P450 isozyme belonging to a subfamily of P450
RT   IIB from liver microsomes of guinea pigs.";
RL   Biochem. Biophys. Res. Commun. 172:607-613(1990).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       In liver microsomes, this enzyme is involved in an NADPH-dependent
CC       electron transport pathway. This isozyme is active upon P.nitroanisole,
CC       aniline, D-benzphetamine, delta(9)-tetrahydrocannabinol (THC) and
CC       strychnine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   AlphaFoldDB; P34033; -.
DR   HOGENOM; CLU_3429526_0_0_1; -.
DR   InParanoid; P34033; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane;
KW   Metal-binding; Microsome; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..>20
FT                   /note="Cytochrome P450IIB"
FT                   /id="PRO_0000051691"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2259 MW;  78DC81280C970A55 CRC64;
     MELSLLLFLA LLLGLLLLLF
//