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P34033 (CP2BX_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome P450IIB

EC=1.14.14.1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length20 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme is active upon P.nitroanisole, aniline, D-benzphetamine, delta(9)-tetrahydrocannabinol (THC) and strychnine.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›20›20Cytochrome P450IIB
PRO_0000051691

Experimental info

Non-terminal residue201

Sequences

Sequence LengthMass (Da)Tools
P34033 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 78DC81280C970A55

FASTA202,259
        10         20 
MELSLLLFLA LLLGLLLLLF 

« Hide

References

[1]"Purification of a cytochrome P450 isozyme belonging to a subfamily of P450 IIB from liver microsomes of guinea pigs."
Narimatsu S., Akutsu Y., Matsunaga T., Watanabe K., Yamamoto I., Yoshimura H.
Biochem. Biophys. Res. Commun. 172:607-613(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
Strain: Hartley.
Tissue: Liver.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000023042; ENSCPOP00000020155; ENSCPOG00000014373.
ENSCPOT00000023301; ENSCPOP00000017659; ENSCPOG00000024851.
ENSCPOT00000023540; ENSCPOP00000014850; ENSCPOG00000020370.

Phylogenomic databases

GeneTreeENSGT00670000097868.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameCP2BX_CAVPO
AccessionPrimary (citable) accession number: P34033
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families