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P34033

- CP2BX_CAVPO

UniProt

P34033 - CP2BX_CAVPO

Protein

Cytochrome P450IIB

Gene
N/A
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme is active upon P.nitroanisole, aniline, D-benzphetamine, delta(9)-tetrahydrocannabinol (THC) and strychnine.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450IIB (EC:1.14.14.1)
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›20›20Cytochrome P450IIBPRO_0000051691Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00670000097868.

    Sequencei

    Sequence statusi: Fragment.

    P34033-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELSLLLFLA LLLGLLLLLF                                    20
    Length:20
    Mass (Da):2,259
    Last modified:February 1, 1994 - v1
    Checksum:i78DC81280C970A55
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei20 – 201

    Genome annotation databases

    EnsembliENSCPOT00000023042; ENSCPOP00000020155; ENSCPOG00000014373.
    ENSCPOT00000023301; ENSCPOP00000017659; ENSCPOG00000024851.
    ENSCPOT00000023540; ENSCPOP00000014850; ENSCPOG00000020370.

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000023042 ; ENSCPOP00000020155 ; ENSCPOG00000014373 .
    ENSCPOT00000023301 ; ENSCPOP00000017659 ; ENSCPOG00000024851 .
    ENSCPOT00000023540 ; ENSCPOP00000014850 ; ENSCPOG00000020370 .

    Phylogenomic databases

    GeneTreei ENSGT00670000097868.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Purification of a cytochrome P450 isozyme belonging to a subfamily of P450 IIB from liver microsomes of guinea pigs."
      Narimatsu S., Akutsu Y., Matsunaga T., Watanabe K., Yamamoto I., Yoshimura H.
      Biochem. Biophys. Res. Commun. 172:607-613(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
      Strain: Hartley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2BX_CAVPO
    AccessioniPrimary (citable) accession number: P34033
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3