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P34033

- CP2BX_CAVPO

UniProt

P34033 - CP2BX_CAVPO

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Protein

Cytochrome P450IIB

Gene
N/A
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme is active upon P.nitroanisole, aniline, D-benzphetamine, delta(9)-tetrahydrocannabinol (THC) and strychnine.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450IIB (EC:1.14.14.1)
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›20›20Cytochrome P450IIBPRO_0000051691Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118775.

Sequencei

Sequence statusi: Fragment.

P34033-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
MELSLLLFLA LLLGLLLLLF
Length:20
Mass (Da):2,259
Last modified:February 1, 1994 - v1
Checksum:i78DC81280C970A55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei20 – 201

Genome annotation databases

EnsembliENSCPOT00000023042; ENSCPOP00000020155; ENSCPOG00000014373.
ENSCPOT00000023301; ENSCPOP00000017659; ENSCPOG00000024851.
ENSCPOT00000023540; ENSCPOP00000014850; ENSCPOG00000020370.

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000023042 ; ENSCPOP00000020155 ; ENSCPOG00000014373 .
ENSCPOT00000023301 ; ENSCPOP00000017659 ; ENSCPOG00000024851 .
ENSCPOT00000023540 ; ENSCPOP00000014850 ; ENSCPOG00000020370 .

Phylogenomic databases

GeneTreei ENSGT00760000118775.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Purification of a cytochrome P450 isozyme belonging to a subfamily of P450 IIB from liver microsomes of guinea pigs."
    Narimatsu S., Akutsu Y., Matsunaga T., Watanabe K., Yamamoto I., Yoshimura H.
    Biochem. Biophys. Res. Commun. 172:607-613(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: Hartley.
    Tissue: Liver.

Entry informationi

Entry nameiCP2BX_CAVPO
AccessioniPrimary (citable) accession number: P34033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3