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Protein

Cytochrome P450IIB

Gene
N/A
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme is active upon P.nitroanisole, aniline, D-benzphetamine, delta9-tetrahydrocannabinol (THC) and strychnine.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450IIB (EC:1.14.14.1)
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516911 – ›20Cytochrome P450IIBAdd BLAST›20

Expressioni

Gene expression databases

BgeeiENSCPOG00000014373.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00880000137861.

Sequencei

Sequence statusi: Fragment.

P34033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
MELSLLLFLA LLLGLLLLLF
Length:20
Mass (Da):2,259
Last modified:February 1, 1994 - v1
Checksum:i78DC81280C970A55
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei201

Genome annotation databases

EnsembliENSCPOT00000023042; ENSCPOP00000020155; ENSCPOG00000014373.
ENSCPOT00000023301; ENSCPOP00000017659; ENSCPOG00000024851.
ENSCPOT00000023540; ENSCPOP00000014850; ENSCPOG00000020370.

Similar proteinsi

Entry informationi

Entry nameiCP2BX_CAVPO
AccessioniPrimary (citable) accession number: P34033
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families