P34033 (CP2BX_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Cytochrome P450IIB EC=1.14.14.1
Organism	Cavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier	10141 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme is active upon P.nitroanisole, aniline, D-benzphetamine, delta(9)-tetrahydrocannabinol (THC) and strychnine.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Cytochrome P450IIB		PRO_0000051691
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P34033 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 78DC81280C970A55	FASTA	20	2,259
	10 20 MELSLLLFLA LLLGLLLLLF

References

[1]

"Purification of a cytochrome P450 isozyme belonging to a subfamily of P450 IIB from liver microsomes of guinea pigs." Narimatsu S., Akutsu Y., Matsunaga T., Watanabe K., Yamamoto I., Yoshimura H. Biochem. Biophys. Res. Commun. 172:607-613(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, CHARACTERIZATION. Strain: Hartley. Tissue: Liver.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000023042; ENSCPOP00000020155; ENSCPOG00000014373. ENSCPOT00000023301; ENSCPOP00000017659; ENSCPOG00000024851. ENSCPOT00000023540; ENSCPOP00000014850; ENSCPOG00000020370.
Phylogenomic databases
GeneTree	ENSGT00670000097868.
Family and domain databases
PROSITE	PS00086. CYTOCHROME_P450. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP2BX_CAVPO

Accession

Primary (citable) accession number: P34033

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program