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Protein

Ran-specific GTPase-activating protein

Gene

Ranbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-specific GTPase-activating protein
Alternative name(s):
HpaII tiny fragments locus 9a protein
Ran-binding protein 1
Short name:
RANBP1
Gene namesi
Name:Ranbp1
Synonyms:Htf9-a, Htf9a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:96269. Ranbp1.

Subcellular locationi

GO - Cellular componenti

  • axon cytoplasm Source: Ensembl
  • centrosome Source: MGI
  • cytoplasm Source: MGI
  • nucleus Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 203202Ran-specific GTPase-activating proteinPRO_0000213668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei13 – 131PhosphothreonineBy similarity
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei150 – 1501N6-acetyllysine; alternateCombined sources
Modified residuei150 – 1501N6-succinyllysine; alternateCombined sources
Modified residuei182 – 1821N6-acetyllysineCombined sources
Modified residuei187 – 1871PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP34022.
MaxQBiP34022.
PaxDbiP34022.
PeptideAtlasiP34022.
PRIDEiP34022.
TopDownProteomicsiP34022.

2D gel databases

REPRODUCTION-2DPAGEP34022.

PTM databases

iPTMnetiP34022.
PhosphoSiteiP34022.
SwissPalmiP34022.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005732.
CleanExiMM_RANBP1.
ExpressionAtlasiP34022. baseline and differential.
GenevisibleiP34022. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202581. 21 interactions.
IntActiP34022. 22 interactions.
MINTiMINT-1850829.
STRINGi10090.ENSMUSP00000111309.

Structurei

3D structure databases

ProteinModelPortaliP34022.
SMRiP34022. Positions 22-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 164139RanBD1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RANBP1 family.Curated
Contains 1 RanBD1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
HOGENOMiHOG000176323.
HOVERGENiHBG006958.
InParanoidiP34022.
KOiK15306.
OMAiKGPGKND.
OrthoDBiEOG091G0Y8B.
PhylomeDBiP34022.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKDSHED HDTSTENADE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK
60 70 80 90 100
MRAKLFRFAS ENDLPEWKER GTGDVKLLKH KEKGTIRLLM RRDKTLKICA
110 120 130 140 150
NHYITPMMEL KPNAGSDRAW VWNTHADFAD ECPKPELLAI RFLNAENAQK
160 170 180 190 200
FKTKFEECRK EIEEREKKGP GKNDNAEKVA EKLEALSVRE AREEAEEKSE

EKQ
Length:203
Mass (Da):23,596
Last modified:April 13, 2004 - v2
Checksum:i4CA6C21DDF5B6F4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91E → A (PubMed:1889746).Curated
Sequence conflicti22 – 243NHD → TTH (PubMed:1889746).Curated
Sequence conflicti33 – 331L → V (PubMed:8255297).Curated
Sequence conflicti33 – 331L → V (PubMed:1889746).Curated
Sequence conflicti67 – 671W → R in BAB25569 (PubMed:16141072).Curated
Sequence conflicti70 – 723RGT → PRH (PubMed:1889746).Curated
Sequence conflicti85 – 851T → P in BAB25569 (PubMed:16141072).Curated
Sequence conflicti126 – 1261A → T (PubMed:1889746).Curated
Sequence conflicti126 – 1261A → T (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56046 mRNA. Translation: CAA39517.1.
L25255 mRNA. Translation: AAA16195.1.
X56045 mRNA. Translation: CAA39516.1.
AK002989 mRNA. Translation: BAB22501.1.
AK008276 mRNA. Translation: BAB25569.1.
AK088781 mRNA. Translation: BAC40569.1.
AK151167 mRNA. Translation: BAE30170.1.
AK166642 mRNA. Translation: BAE38911.1.
AK167053 mRNA. Translation: BAE39217.1.
BC061140 mRNA. Translation: AAH61140.1.
CCDSiCCDS37280.1.
PIRiJQ1973.
RefSeqiNP_035369.2. NM_011239.2.
UniGeneiMm.235287.

Genome annotation databases

EnsembliENSMUST00000115645; ENSMUSP00000111309; ENSMUSG00000005732.
ENSMUST00000183528; ENSMUSP00000139059; ENSMUSG00000099164.
GeneIDi19385.
KEGGimmu:19385.
UCSCiuc007ymy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56046 mRNA. Translation: CAA39517.1.
L25255 mRNA. Translation: AAA16195.1.
X56045 mRNA. Translation: CAA39516.1.
AK002989 mRNA. Translation: BAB22501.1.
AK008276 mRNA. Translation: BAB25569.1.
AK088781 mRNA. Translation: BAC40569.1.
AK151167 mRNA. Translation: BAE30170.1.
AK166642 mRNA. Translation: BAE38911.1.
AK167053 mRNA. Translation: BAE39217.1.
BC061140 mRNA. Translation: AAH61140.1.
CCDSiCCDS37280.1.
PIRiJQ1973.
RefSeqiNP_035369.2. NM_011239.2.
UniGeneiMm.235287.

3D structure databases

ProteinModelPortaliP34022.
SMRiP34022. Positions 22-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202581. 21 interactions.
IntActiP34022. 22 interactions.
MINTiMINT-1850829.
STRINGi10090.ENSMUSP00000111309.

PTM databases

iPTMnetiP34022.
PhosphoSiteiP34022.
SwissPalmiP34022.

2D gel databases

REPRODUCTION-2DPAGEP34022.

Proteomic databases

EPDiP34022.
MaxQBiP34022.
PaxDbiP34022.
PeptideAtlasiP34022.
PRIDEiP34022.
TopDownProteomicsiP34022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115645; ENSMUSP00000111309; ENSMUSG00000005732.
ENSMUST00000183528; ENSMUSP00000139059; ENSMUSG00000099164.
GeneIDi19385.
KEGGimmu:19385.
UCSCiuc007ymy.1. mouse.

Organism-specific databases

CTDi5902.
MGIiMGI:96269. Ranbp1.

Phylogenomic databases

eggNOGiKOG0864. Eukaryota.
COG5171. LUCA.
GeneTreeiENSGT00840000129823.
HOGENOMiHOG000176323.
HOVERGENiHBG006958.
InParanoidiP34022.
KOiK15306.
OMAiKGPGKND.
OrthoDBiEOG091G0Y8B.
PhylomeDBiP34022.

Miscellaneous databases

ChiTaRSiRanbp1. mouse.
PROiP34022.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005732.
CleanExiMM_RANBP1.
ExpressionAtlasiP34022. baseline and differential.
GenevisibleiP34022. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRANG_MOUSE
AccessioniPrimary (citable) accession number: P34022
Secondary accession number(s): P34023
, Q3TL81, Q9D894, Q9DCA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 13, 2004
Last modified: September 7, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Htf9a (RanBP1) and Htf9c are transcribed with opposite polarity from complementary DNA strands from a shared bidirectional TATA-less promoter.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.