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Protein

Ran-specific GTPase-activating protein

Gene

Ranbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (PubMed:9428644). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (PubMed:9428644). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:9428644). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity).By similarity1 Publication

Miscellaneous

Htf9a (RanBP1) and Htf9c are transcribed with opposite polarity from complementary DNA strands from a shared bidirectional TATA-less promoter.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-specific GTPase-activating protein
Alternative name(s):
HpaII tiny fragments locus 9a protein
Ran-binding protein 1
Short name:
RANBP1
Gene namesi
Name:Ranbp1
Synonyms:Htf9-a, Htf9a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:96269 Ranbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002136682 – 203Ran-specific GTPase-activating proteinAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei60PhosphoserineCombined sources1
Modified residuei150N6-acetyllysine; alternateCombined sources1
Modified residuei150N6-succinyllysine; alternateCombined sources1
Modified residuei182N6-acetyllysineCombined sources1
Modified residuei187PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP34022
MaxQBiP34022
PaxDbiP34022
PeptideAtlasiP34022
PRIDEiP34022
TopDownProteomicsiP34022

2D gel databases

REPRODUCTION-2DPAGEiP34022

PTM databases

iPTMnetiP34022
PhosphoSitePlusiP34022
SwissPalmiP34022

Expressioni

Gene expression databases

BgeeiENSMUSG00000005732
CleanExiMM_RANBP1
ExpressionAtlasiP34022 baseline and differential
GenevisibleiP34022 MM

Interactioni

Subunit structurei

Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN (PubMed:8255297, PubMed:7891706, PubMed:8896452). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (By similarity). Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (PubMed:9428644). Identified in a complex with nucleotide-free RAN and RCC1 (By similarity).By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202581, 21 interactors
IntActiP34022, 22 interactors
MINTiP34022
STRINGi10090.ENSMUSP00000111309

Structurei

3D structure databases

ProteinModelPortaliP34022
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 164RanBD1PROSITE-ProRule annotationAdd BLAST139

Sequence similaritiesi

Belongs to the RANBP1 family.Curated

Phylogenomic databases

eggNOGiKOG0864 Eukaryota
COG5171 LUCA
GeneTreeiENSGT00900000141073
HOGENOMiHOG000176323
HOVERGENiHBG006958
InParanoidiP34022
KOiK15306
OMAiSEDVHFE
OrthoDBiEOG091G0Y8B
PhylomeDBiP34022

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000156 Ran_bind_dom
PfamiView protein in Pfam
PF00638 Ran_BP1, 1 hit
SMARTiView protein in SMART
SM00160 RanBD, 1 hit
PROSITEiView protein in PROSITE
PS50196 RANBD1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKDSHED HDTSTENADE SNHDPQFEPI VSLPEQEIKT LEEDEEELFK
60 70 80 90 100
MRAKLFRFAS ENDLPEWKER GTGDVKLLKH KEKGTIRLLM RRDKTLKICA
110 120 130 140 150
NHYITPMMEL KPNAGSDRAW VWNTHADFAD ECPKPELLAI RFLNAENAQK
160 170 180 190 200
FKTKFEECRK EIEEREKKGP GKNDNAEKVA EKLEALSVRE AREEAEEKSE

EKQ
Length:203
Mass (Da):23,596
Last modified:April 13, 2004 - v2
Checksum:i4CA6C21DDF5B6F4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9E → A (PubMed:1889746).Curated1
Sequence conflicti22 – 24NHD → TTH (PubMed:1889746).Curated3
Sequence conflicti33L → V (PubMed:8255297).Curated1
Sequence conflicti33L → V (PubMed:1889746).Curated1
Sequence conflicti67W → R in BAB25569 (PubMed:16141072).Curated1
Sequence conflicti70 – 72RGT → PRH (PubMed:1889746).Curated3
Sequence conflicti85T → P in BAB25569 (PubMed:16141072).Curated1
Sequence conflicti126A → T (PubMed:1889746).Curated1
Sequence conflicti126A → T (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56046 mRNA Translation: CAA39517.1
L25255 mRNA Translation: AAA16195.1
X56045 mRNA Translation: CAA39516.1
AK002989 mRNA Translation: BAB22501.1
AK008276 mRNA Translation: BAB25569.1
AK088781 mRNA Translation: BAC40569.1
AK151167 mRNA Translation: BAE30170.1
AK166642 mRNA Translation: BAE38911.1
AK167053 mRNA Translation: BAE39217.1
BC061140 mRNA Translation: AAH61140.1
CCDSiCCDS37280.1
PIRiJQ1973
RefSeqiNP_035369.2, NM_011239.2
UniGeneiMm.235287

Genome annotation databases

EnsembliENSMUST00000115645; ENSMUSP00000111309; ENSMUSG00000005732
ENSMUST00000183528; ENSMUSP00000139059; ENSMUSG00000099164
GeneIDi19385
KEGGimmu:19385
UCSCiuc007ymy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRANG_MOUSE
AccessioniPrimary (citable) accession number: P34022
Secondary accession number(s): P34023
, Q3TL81, Q9D894, Q9DCA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: April 13, 2004
Last modified: April 25, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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