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Protein

Autolytic lysozyme

Gene

lyc

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5PROSITE-ProRule annotation1
Active sitei91PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH25. Glycoside Hydrolase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Autolytic lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Autolysin
Gene namesi
Name:lyc
Ordered Locus Names:CA_C0554
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002082641 – 324Autolytic lysozymeAdd BLAST324

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi272562.CA_C0554.

Structurei

3D structure databases

ProteinModelPortaliP34020.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati212 – 2341Add BLAST23
Repeati235 – 2542Add BLAST20
Repeati255 – 2773Add BLAST23
Repeati278 – 3004Add BLAST23
Repeati301 – 3245Add BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 3245 X 23 AA tandem repeatsAdd BLAST113

Sequence similaritiesi

Belongs to the glycosyl hydrolase 25 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107YXZ. Bacteria.
COG3409. LUCA.
COG3757. LUCA.
HOGENOMiHOG000057939.
KOiK01185.
OMAiPISILQF.

Family and domain databases

Gene3Di1.10.101.10. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF01183. Glyco_hydro_25. 1 hit.
PF01471. PG_binding_1. 2 hits.
[Graphical view]
SMARTiSM00641. Glyco_25. 2 hits.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGIDIYSGQ GSVDFNAVKE SGVEVVYIKA TEGLTYTDST YKDFYDGAKN
60 70 80 90 100
AGLKIGFYHY LRANDPTSEA EHFFNTISGL SLDCKCAIDV EVTLGQSIDQ
110 120 130 140 150
ISSNVRKFAD YLINKGLDVC VYTYTNFYKD NLNSTVKDLP LWIAEYGVSK
160 170 180 190 200
PNIDASYVGF QYSDSGSVNG ISGSADLDEF SEGILVGGTV VIDPGQGGDD
210 220 230 240 250
NIKAIQQDLN ILLKRGLEVD GIEGPETEAA IKDFQSIMGL TVDGIWGTNT
260 270 280 290 300
SGAAQQIFSR PLDGVAYPHY EYATRYIQYR VGASVDGTFG SGTKAKVAAW
310 320
QSNQGLMADG VVGSATWSKL LDEN
Length:324
Mass (Da):34,978
Last modified:February 1, 1994 - v1
Checksum:i32F09D6D77D015E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68865 Genomic DNA. Translation: AAA23250.1.
AE001437 Genomic DNA. Translation: AAK78533.1.
PIRiB96968.
JH0441.
RefSeqiNP_347193.1. NC_003030.1.
WP_010963875.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK78533; AAK78533; CA_C0554.
GeneIDi1116737.
KEGGicac:CA_C0554.
PATRICi32035475. VBICloAce74127_0759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68865 Genomic DNA. Translation: AAA23250.1.
AE001437 Genomic DNA. Translation: AAK78533.1.
PIRiB96968.
JH0441.
RefSeqiNP_347193.1. NC_003030.1.
WP_010963875.1. NC_003030.1.

3D structure databases

ProteinModelPortaliP34020.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C0554.

Protein family/group databases

CAZyiGH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK78533; AAK78533; CA_C0554.
GeneIDi1116737.
KEGGicac:CA_C0554.
PATRICi32035475. VBICloAce74127_0759.

Phylogenomic databases

eggNOGiENOG4107YXZ. Bacteria.
COG3409. LUCA.
COG3757. LUCA.
HOGENOMiHOG000057939.
KOiK01185.
OMAiPISILQF.

Family and domain databases

Gene3Di1.10.101.10. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF01183. Glyco_hydro_25. 1 hit.
PF01471. PG_binding_1. 2 hits.
[Graphical view]
SMARTiSM00641. Glyco_25. 2 hits.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYS_CLOAB
AccessioniPrimary (citable) accession number: P34020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.