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P34020

- LYS_CLOAB

UniProt

P34020 - LYS_CLOAB

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Protein

Autolytic lysozyme

Gene
lyc, CA_C0554
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei5 – 51 By similarity
Active sitei91 – 911 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell wall macromolecule catabolic process Source: InterPro
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
  5. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciCACE272562:GJIH-595-MONOMER.

Protein family/group databases

CAZyiGH25. Glycoside Hydrolase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Autolytic lysozyme (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase
Autolysin
Gene namesi
Name:lyc
Ordered Locus Names:CA_C0554
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Autolytic lysozymePRO_0000208264Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi272562.CA_C0554.

Structurei

3D structure databases

ProteinModelPortaliP34020.
SMRiP34020. Positions 285-320.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati212 – 234231Add
BLAST
Repeati235 – 254202Add
BLAST
Repeati255 – 277233Add
BLAST
Repeati278 – 300234Add
BLAST
Repeati301 – 324245Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 3241135 X 23 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3409.
HOGENOMiHOG000057939.
KOiK01185.
OMAiDITEVCL.
OrthoDBiEOG6SV55S.

Family and domain databases

Gene3Di1.10.101.10. 2 hits.
3.20.20.80. 1 hit.
InterProiIPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PfamiPF01183. Glyco_hydro_25. 1 hit.
PF01471. PG_binding_1. 2 hits.
[Graphical view]
SMARTiSM00641. Glyco_25. 2 hits.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34020-1 [UniParc]FASTAAdd to Basket

« Hide

MKGIDIYSGQ GSVDFNAVKE SGVEVVYIKA TEGLTYTDST YKDFYDGAKN    50
AGLKIGFYHY LRANDPTSEA EHFFNTISGL SLDCKCAIDV EVTLGQSIDQ 100
ISSNVRKFAD YLINKGLDVC VYTYTNFYKD NLNSTVKDLP LWIAEYGVSK 150
PNIDASYVGF QYSDSGSVNG ISGSADLDEF SEGILVGGTV VIDPGQGGDD 200
NIKAIQQDLN ILLKRGLEVD GIEGPETEAA IKDFQSIMGL TVDGIWGTNT 250
SGAAQQIFSR PLDGVAYPHY EYATRYIQYR VGASVDGTFG SGTKAKVAAW 300
QSNQGLMADG VVGSATWSKL LDEN 324
Length:324
Mass (Da):34,978
Last modified:February 1, 1994 - v1
Checksum:i32F09D6D77D015E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68865 Genomic DNA. Translation: AAA23250.1.
AE001437 Genomic DNA. Translation: AAK78533.1.
PIRiB96968.
JH0441.
RefSeqiNP_347193.1. NC_003030.1.
WP_010963875.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK78533; AAK78533; CA_C0554.
GeneIDi1116737.
KEGGicac:CA_C0554.
PATRICi32035475. VBICloAce74127_0759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M68865 Genomic DNA. Translation: AAA23250.1 .
AE001437 Genomic DNA. Translation: AAK78533.1 .
PIRi B96968.
JH0441.
RefSeqi NP_347193.1. NC_003030.1.
WP_010963875.1. NC_003030.1.

3D structure databases

ProteinModelPortali P34020.
SMRi P34020. Positions 285-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_C0554.

Protein family/group databases

CAZyi GH25. Glycoside Hydrolase Family 25.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK78533 ; AAK78533 ; CA_C0554 .
GeneIDi 1116737.
KEGGi cac:CA_C0554.
PATRICi 32035475. VBICloAce74127_0759.

Phylogenomic databases

eggNOGi COG3409.
HOGENOMi HOG000057939.
KOi K01185.
OMAi DITEVCL.
OrthoDBi EOG6SV55S.

Enzyme and pathway databases

BioCyci CACE272562:GJIH-595-MONOMER.

Family and domain databases

Gene3Di 1.10.101.10. 2 hits.
3.20.20.80. 1 hit.
InterProi IPR002053. Glyco_hydro_25.
IPR008270. Glyco_hydro_25_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR018077. Glyco_hydro_fam25_subgr.
IPR017853. Glycoside_hydrolase_SF.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
Pfami PF01183. Glyco_hydro_25. 1 hit.
PF01471. PG_binding_1. 2 hits.
[Graphical view ]
SMARTi SM00641. Glyco_25. 2 hits.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00953. GLYCOSYL_HYDROL_F25. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the lyc gene encoding the autolytic lysozyme of Clostridium acetobutylicum ATCC824: comparison with other lytic enzymes."
    Croux C., Garcia J.L.
    Gene 104:25-31(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  3. "Purification and characterization of an extracellular muramidase of Clostridium acetobutylicum ATCC 824 that acts on non-N-acetylated peptidoglycan."
    Croux C., Canard B., Goma G., Soucaille P.
    Appl. Environ. Microbiol. 58:1075-1081(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-23, CHARACTERIZATION.
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  4. "Autolysis of Clostridium acetobutylicum ATCC 824."
    Croux C., Canard B., Goma G., Soucaille P.
    J. Gen. Microbiol. 138:861-869(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiLYS_CLOAB
AccessioniPrimary (citable) accession number: P34020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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