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Protein

Squalene--hopene cyclase

Gene

shc

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of squalene into hopene.

Catalytic activityi

Squalene = hop-22(29)-ene.
Hopan-22-ol = squalene + H2O.

Pathwayi: hopanoid biosynthesis

This protein is involved in the pathway hopanoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hopanoid biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase

Enzyme and pathway databases

BRENDAi5.4.99.17. 6765.
UniPathwayiUPA00337.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene--hopene cyclase (EC:4.2.1.129, EC:5.4.99.17)
Alternative name(s):
Squalene--hopanol cyclase
Gene namesi
Name:shc
Ordered Locus Names:ZMO0872
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658Squalene--hopene cyclasePRO_0000072653Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP33990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati69 – 11042PFTB 1Add
BLAST
Repeati418 – 45942PFTB 2Add
BLAST
Repeati486 – 52641PFTB 3Add
BLAST
Repeati534 – 58451PFTB 4Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000220823.
KOiK06045.
OMAiAFQYRND.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR006400. Hopene-cyclase.
IPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01507. hopene_cyclase. 1 hit.
TIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSTSSAFH HSPLSDDVEP IIQKATRALL EKQHQDGHWV FELEADATIP
60 70 80 90 100
AEYILLKHYL GEPQDLEIEA KIGRYLRRIQ GEHGGWSLFY GGDLDLSATV
110 120 130 140 150
KAYFALKMIG DSPDAPHMLR ARNEILARGG AMRANVFTRI QLALFGAMSW
160 170 180 190 200
EHVPQMPVEL MLMPEWFPVH INKMAYWART VLVPLLVLQA LKPVARNRRG
210 220 230 240 250
ILVDELFVPD VLPTLQESGD PIWRRFFSAL DKVLHKVEPY WPKNMRAKAI
260 270 280 290 300
HSCVHFVTER LNGEDGLGAI YPAIANSVMM YDALGYPENH PERAIARRAV
310 320 330 340 350
EKLMVLDGTE DQGDKEVYCQ PCLSPIWDTA LVAHAMLEVG GDEAEKSAIS
360 370 380 390 400
ALSWLKPQQI LDVKGDWAWR RPDLRPGGWA FQYRNDYYPD VDDTAVVTMA
410 420 430 440 450
MDRAAKLSDL RDDFEESKAR AMEWTIGMQS DNGGWGAFDA NNSYTYLNNI
460 470 480 490 500
PFADHGALLD PPTVDVSARC VSMMAQAGIS ITDPKMKAAV DYLLKEQEED
510 520 530 540 550
GSWFGRWGVN YIYGTWSALC ALNVAALPHD HLAIQKAVAW LKTIQNEDGG
560 570 580 590 600
WGENCDSYAL DYSGYEPMDS TASQTAWALL GLMAVGEANS EAVTKGINWL
610 620 630 640 650
AQNQDEEGLW KEDYYSGGGF PRVFYLRYHG YSKYFPLWAL ARYRNLKKAN

QPIVHYGM
Length:658
Mass (Da):74,109
Last modified:February 15, 2005 - v2
Checksum:i42D2D8FC06EA1D9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341H → Q (PubMed:7894707).Curated
Sequence conflicti34 – 341H → Q (Ref. 2) Curated
Sequence conflicti34 – 341H → Q (Ref. 3) Curated
Sequence conflicti64 – 641Q → E (PubMed:7894707).Curated
Sequence conflicti64 – 641Q → E (Ref. 2) Curated
Sequence conflicti64 – 641Q → E (Ref. 3) Curated
Sequence conflicti411 – 4111R → H (PubMed:7894707).Curated
Sequence conflicti411 – 4111R → H (Ref. 2) Curated
Sequence conflicti411 – 4111R → H (Ref. 3) Curated
Sequence conflicti534 – 5341I → V (PubMed:7894707).Curated
Sequence conflicti534 – 5341I → V (Ref. 2) Curated
Sequence conflicti534 – 5341I → V (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80766 Genomic DNA. Translation: CAA56749.1.
X73561 Genomic DNA. Translation: CAA51958.1.
AJ001401 Genomic DNA. Translation: CAA04735.1.
AF203881 Genomic DNA. Translation: AAF12829.1.
AE008692 Genomic DNA. Translation: AAV89496.1.
PIRiS37494.
RefSeqiWP_011240738.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89496; AAV89496; ZMO0872.
KEGGizmo:ZMO0872.
PATRICi32567038. VBIZymMob102260_0823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80766 Genomic DNA. Translation: CAA56749.1.
X73561 Genomic DNA. Translation: CAA51958.1.
AJ001401 Genomic DNA. Translation: CAA04735.1.
AF203881 Genomic DNA. Translation: AAF12829.1.
AE008692 Genomic DNA. Translation: AAV89496.1.
PIRiS37494.
RefSeqiWP_011240738.1. NC_006526.2.

3D structure databases

ProteinModelPortaliP33990.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV89496; AAV89496; ZMO0872.
KEGGizmo:ZMO0872.
PATRICi32567038. VBIZymMob102260_0823.

Phylogenomic databases

HOGENOMiHOG000220823.
KOiK06045.
OMAiAFQYRND.

Enzyme and pathway databases

UniPathwayiUPA00337.
BRENDAi5.4.99.17. 6765.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR006400. Hopene-cyclase.
IPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01507. hopene_cyclase. 1 hit.
TIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSQHC_ZYMMO
AccessioniPrimary (citable) accession number: P33990
Secondary accession number(s): Q5NP64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 15, 2005
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.