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Protein

Squalene--hopene cyclase

Gene

shc

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of squalene into hopene.

Catalytic activityi

Squalene = hop-22(29)-ene.
Hopan-22-ol = squalene + H2O.

Pathwayi: hopanoid biosynthesis

This protein is involved in the pathway hopanoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hopanoid biosynthesis and in Secondary metabolite biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase

Enzyme and pathway databases

BRENDAi5.4.99.17. 6765.
UniPathwayiUPA00337.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene--hopene cyclase (EC:4.2.1.129, EC:5.4.99.17)
Alternative name(s):
Squalene--hopanol cyclase
Gene namesi
Name:shc
Ordered Locus Names:ZMO0872
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000001173 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726531 – 658Squalene--hopene cyclaseAdd BLAST658

Structurei

3D structure databases

ProteinModelPortaliP33990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati69 – 110PFTB 1Add BLAST42
Repeati418 – 459PFTB 2Add BLAST42
Repeati486 – 526PFTB 3Add BLAST41
Repeati534 – 584PFTB 4Add BLAST51

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000220823.
KOiK06045.
OMAiAFQYRND.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR006400. Hopene-cyclase.
IPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01507. hopene_cyclase. 1 hit.
TIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSTSSAFH HSPLSDDVEP IIQKATRALL EKQHQDGHWV FELEADATIP
60 70 80 90 100
AEYILLKHYL GEPQDLEIEA KIGRYLRRIQ GEHGGWSLFY GGDLDLSATV
110 120 130 140 150
KAYFALKMIG DSPDAPHMLR ARNEILARGG AMRANVFTRI QLALFGAMSW
160 170 180 190 200
EHVPQMPVEL MLMPEWFPVH INKMAYWART VLVPLLVLQA LKPVARNRRG
210 220 230 240 250
ILVDELFVPD VLPTLQESGD PIWRRFFSAL DKVLHKVEPY WPKNMRAKAI
260 270 280 290 300
HSCVHFVTER LNGEDGLGAI YPAIANSVMM YDALGYPENH PERAIARRAV
310 320 330 340 350
EKLMVLDGTE DQGDKEVYCQ PCLSPIWDTA LVAHAMLEVG GDEAEKSAIS
360 370 380 390 400
ALSWLKPQQI LDVKGDWAWR RPDLRPGGWA FQYRNDYYPD VDDTAVVTMA
410 420 430 440 450
MDRAAKLSDL RDDFEESKAR AMEWTIGMQS DNGGWGAFDA NNSYTYLNNI
460 470 480 490 500
PFADHGALLD PPTVDVSARC VSMMAQAGIS ITDPKMKAAV DYLLKEQEED
510 520 530 540 550
GSWFGRWGVN YIYGTWSALC ALNVAALPHD HLAIQKAVAW LKTIQNEDGG
560 570 580 590 600
WGENCDSYAL DYSGYEPMDS TASQTAWALL GLMAVGEANS EAVTKGINWL
610 620 630 640 650
AQNQDEEGLW KEDYYSGGGF PRVFYLRYHG YSKYFPLWAL ARYRNLKKAN

QPIVHYGM
Length:658
Mass (Da):74,109
Last modified:February 15, 2005 - v2
Checksum:i42D2D8FC06EA1D9C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34H → Q (PubMed:7894707).Curated1
Sequence conflicti34H → Q (Ref. 2) Curated1
Sequence conflicti34H → Q (Ref. 3) Curated1
Sequence conflicti64Q → E (PubMed:7894707).Curated1
Sequence conflicti64Q → E (Ref. 2) Curated1
Sequence conflicti64Q → E (Ref. 3) Curated1
Sequence conflicti411R → H (PubMed:7894707).Curated1
Sequence conflicti411R → H (Ref. 2) Curated1
Sequence conflicti411R → H (Ref. 3) Curated1
Sequence conflicti534I → V (PubMed:7894707).Curated1
Sequence conflicti534I → V (Ref. 2) Curated1
Sequence conflicti534I → V (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80766 Genomic DNA. Translation: CAA56749.1.
X73561 Genomic DNA. Translation: CAA51958.1.
AJ001401 Genomic DNA. Translation: CAA04735.1.
AF203881 Genomic DNA. Translation: AAF12829.1.
AE008692 Genomic DNA. Translation: AAV89496.1.
PIRiS37494.
RefSeqiWP_011240738.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89496; AAV89496; ZMO0872.
KEGGizmo:ZMO0872.
PATRICi32567038. VBIZymMob102260_0823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80766 Genomic DNA. Translation: CAA56749.1.
X73561 Genomic DNA. Translation: CAA51958.1.
AJ001401 Genomic DNA. Translation: CAA04735.1.
AF203881 Genomic DNA. Translation: AAF12829.1.
AE008692 Genomic DNA. Translation: AAV89496.1.
PIRiS37494.
RefSeqiWP_011240738.1. NC_006526.2.

3D structure databases

ProteinModelPortaliP33990.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV89496; AAV89496; ZMO0872.
KEGGizmo:ZMO0872.
PATRICi32567038. VBIZymMob102260_0823.

Phylogenomic databases

HOGENOMiHOG000220823.
KOiK06045.
OMAiAFQYRND.

Enzyme and pathway databases

UniPathwayiUPA00337.
BRENDAi5.4.99.17. 6765.

Family and domain databases

CDDicd02892. SQCY_1. 1 hit.
Gene3Di1.50.10.20. 2 hits.
InterProiIPR006400. Hopene-cyclase.
IPR032696. SQ_cyclase_C.
IPR032697. SQ_cyclase_N.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF13243. SQHop_cyclase_C. 1 hit.
PF13249. SQHop_cyclase_N. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01507. hopene_cyclase. 1 hit.
TIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSQHC_ZYMMO
AccessioniPrimary (citable) accession number: P33990
Secondary accession number(s): Q5NP64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 15, 2005
Last modified: October 5, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.