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Protein

Dual specificity protein kinase TTK

Gene

TTK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Inhibited by the ATP-competitive kinase inhibitor, SP600125.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei553ATPPROSITE-ProRule annotation1
Active sitei647Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi531 – 539ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
  • protein serine/threonine kinase activity Source: ProtInc
  • protein tyrosine kinase activity Source: ProtInc

GO - Biological processi

  • chromosome separation Source: InterPro
  • female meiosis chromosome segregation Source: Ensembl
  • meiotic spindle assembly checkpoint Source: Ensembl
  • mitotic spindle assembly checkpoint Source: ProtInc
  • mitotic spindle organization Source: ProtInc
  • peptidyl-serine phosphorylation Source: Ensembl
  • peptidyl-threonine phosphorylation Source: Ensembl
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  • protein autophosphorylation Source: Ensembl
  • protein localization to kinetochore Source: Ensembl
  • protein localization to meiotic spindle midzone Source: Ensembl
  • spindle organization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS03614-MONOMER.
BRENDAi2.7.12.1. 2681.
SignaLinkiP33981.
SIGNORiP33981.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein kinase TTK (EC:2.7.12.1)
Alternative name(s):
Phosphotyrosine picked threonine-protein kinase
Short name:
PYT
Gene namesi
Name:TTK
Synonyms:MPS1, MPS1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12401. TTK.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • kinetochore Source: Ensembl
  • membrane Source: UniProtKB
  • spindle Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi664D → A: Loss of kinase activity. 2 Publications1
Mutagenesisi686T → A: Loss of kinase activity. 1 Publication1

Organism-specific databases

DisGeNETi7272.
OpenTargetsiENSG00000112742.
PharmGKBiPA37066.

Chemistry databases

ChEMBLiCHEMBL3983.
GuidetoPHARMACOLOGYi2264.

Polymorphism and mutation databases

BioMutaiTTK.
DMDMi160112977.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867741 – 857Dual specificity protein kinase TTKAdd BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei33PhosphothreonineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei821PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP33981.
MaxQBiP33981.
PaxDbiP33981.
PeptideAtlasiP33981.
PRIDEiP33981.

PTM databases

iPTMnetiP33981.
PhosphoSitePlusiP33981.

Expressioni

Tissue specificityi

Present in rapidly proliferating cell lines.

Gene expression databases

BgeeiENSG00000112742.
CleanExiHS_TTK.
ExpressionAtlasiP33981. baseline and differential.
GenevisibleiP33981. HS.

Organism-specific databases

HPAiCAB010166.
CAB013229.
HPA016834.

Interactioni

Subunit structurei

Interacts with TPR; the interactions occurs in a microtubule-independent manner.2 Publications

Protein-protein interaction databases

BioGridi113123. 71 interactors.
DIPiDIP-40642N.
IntActiP33981. 35 interactors.
MINTiMINT-1203816.
STRINGi9606.ENSP00000358813.

Chemistry databases

BindingDBiP33981.

Structurei

Secondary structure

1857
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi62 – 75Combined sources14
Helixi81 – 97Combined sources17
Helixi100 – 103Combined sources4
Helixi107 – 123Combined sources17
Helixi125 – 127Combined sources3
Helixi129 – 138Combined sources10
Helixi143 – 155Combined sources13
Helixi159 – 171Combined sources13
Helixi177 – 188Combined sources12
Beta strandi517 – 520Combined sources4
Beta strandi523 – 533Combined sources11
Beta strandi535 – 543Combined sources9
Beta strandi549 – 556Combined sources8
Turni557 – 559Combined sources3
Helixi562 – 577Combined sources16
Turni578 – 581Combined sources4
Beta strandi583 – 585Combined sources3
Beta strandi588 – 593Combined sources6
Beta strandi595 – 602Combined sources8
Beta strandi606 – 608Combined sources3
Helixi609 – 614Combined sources6
Beta strandi616 – 618Combined sources3
Helixi621 – 640Combined sources20
Helixi650 – 652Combined sources3
Beta strandi653 – 656Combined sources4
Beta strandi659 – 662Combined sources4
Beta strandi666 – 668Combined sources3
Turni686 – 689Combined sources4
Helixi692 – 696Combined sources5
Helixi713 – 729Combined sources17
Turni733 – 736Combined sources4
Helixi740 – 748Combined sources9
Beta strandi750 – 752Combined sources3
Helixi762 – 771Combined sources10
Turni776 – 778Combined sources3
Helixi782 – 785Combined sources4
Helixi789 – 792Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X9EX-ray3.10A514-828[»]
2ZMCX-ray3.14A510-857[»]
2ZMDX-ray2.88A510-857[»]
3CEKX-ray2.30A519-808[»]
3DBQX-ray2.70A515-857[»]
3GFWX-ray2.74A519-808[»]
3H9FX-ray2.60A519-808[»]
3HMNX-ray2.70A510-809[»]
3HMOX-ray2.40A510-809[»]
3HMPX-ray2.30A510-809[»]
3VQUX-ray2.40A516-820[»]
3W1FX-ray2.70A516-820[»]
3WYXX-ray2.90A516-820[»]
3WYYX-ray3.05A516-820[»]
3WZJX-ray2.75A516-820[»]
3WZKX-ray2.30A516-820[»]
4B94X-ray2.20A/B/C/D62-239[»]
4BHZX-ray2.85A519-808[»]
4BI0X-ray2.84A519-808[»]
4BI1X-ray2.70A519-808[»]
4BI2X-ray3.11A519-808[»]
4C4EX-ray2.60A519-808[»]
4C4FX-ray2.36A519-808[»]
4C4GX-ray2.65A519-808[»]
4C4HX-ray2.80A519-808[»]
4C4IX-ray2.65A519-808[»]
4C4JX-ray2.50A519-808[»]
4CV8X-ray3.00A519-808[»]
4CV9X-ray2.50A519-808[»]
4CVAX-ray2.50A519-808[»]
4D2SX-ray2.50A514-795[»]
4H7XX-ray2.60A/B55-210[»]
4H7YX-ray1.80A/B/C/D55-210[»]
4JS8X-ray1.94A515-795[»]
4JT3X-ray2.20A515-795[»]
4O6LX-ray2.38A/B515-795[»]
4ZEGX-ray2.33A515-795[»]
5AP0X-ray2.15A519-808[»]
5AP1X-ray2.05A519-808[»]
5AP2X-ray2.80A519-808[»]
5AP3X-ray2.70A519-808[»]
5AP4X-ray2.85A519-808[»]
5AP5X-ray2.80A519-808[»]
5AP6X-ray2.10A519-808[»]
5AP7X-ray2.45A519-808[»]
5EH0X-ray2.18A519-794[»]
5EHYX-ray2.26A519-808[»]
5EI2X-ray2.67A519-808[»]
5EI6X-ray2.01A519-808[»]
5EI8X-ray2.17A519-753[»]
5LJJX-ray3.00A519-808[»]
ProteinModelPortaliP33981.
SMRiP33981.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33981.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini525 – 791Protein kinasePROSITE-ProRule annotationAdd BLAST267

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0596. Eukaryota.
ENOG410XRRQ. LUCA.
GeneTreeiENSGT00790000123008.
HOGENOMiHOG000013174.
HOVERGENiHBG001029.
InParanoidiP33981.
KOiK08866.
OMAiMSCFRTP.
OrthoDBiEOG091G0GP7.
PhylomeDBiP33981.
TreeFamiTF105420.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR027084. Dual_sp_prot_kinse_Ttk.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR22974:SF21. PTHR22974:SF21. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P33981-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESEDLSGRE LTIDSIMNKV RDIKNKFKNE DLTDELSLNK ISADTTDNSG
60 70 80 90 100
TVNQIMMMAN NPEDWLSLLL KLEKNSVPLS DALLNKLIGR YSQAIEALPP
110 120 130 140 150
DKYGQNESFA RIQVRFAELK AIQEPDDARD YFQMARANCK KFAFVHISFA
160 170 180 190 200
QFELSQGNVK KSKQLLQKAV ERGAVPLEML EIALRNLNLQ KKQLLSEEEK
210 220 230 240 250
KNLSASTVLT AQESFSGSLG HLQNRNNSCD SRGQTTKARF LYGENMPPQD
260 270 280 290 300
AEIGYRNSLR QTNKTKQSCP FGRVPVNLLN SPDCDVKTDD SVVPCFMKRQ
310 320 330 340 350
TSRSECRDLV VPGSKPSGND SCELRNLKSV QNSHFKEPLV SDEKSSELII
360 370 380 390 400
TDSITLKNKT ESSLLAKLEE TKEYQEPEVP ESNQKQWQSK RKSECINQNP
410 420 430 440 450
AASSNHWQIP ELARKVNTEQ KHTTFEQPVF SVSKQSPPIS TSKWFDPKSI
460 470 480 490 500
CKTPSSNTLD DYMSCFRTPV VKNDFPPACQ LSTPYGQPAC FQQQQHQILA
510 520 530 540 550
TPLQNLQVLA SSSANECISV KGRIYSILKQ IGSGGSSKVF QVLNEKKQIY
560 570 580 590 600
AIKYVNLEEA DNQTLDSYRN EIAYLNKLQQ HSDKIIRLYD YEITDQYIYM
610 620 630 640 650
VMECGNIDLN SWLKKKKSID PWERKSYWKN MLEAVHTIHQ HGIVHSDLKP
660 670 680 690 700
ANFLIVDGML KLIDFGIANQ MQPDTTSVVK DSQVGTVNYM PPEAIKDMSS
710 720 730 740 750
SRENGKSKSK ISPKSDVWSL GCILYYMTYG KTPFQQIINQ ISKLHAIIDP
760 770 780 790 800
NHEIEFPDIP EKDLQDVLKC CLKRDPKQRI SIPELLAHPY VQIQTHPVNQ
810 820 830 840 850
MAKGTTEEMK YVLGQLVGLN SPNSILKAAK TLYEHYSGGE SHNSSSSKTF

EKKRGKK
Length:857
Mass (Da):97,072
Last modified:November 13, 2007 - v2
Checksum:i51F40A3CD1677AC5
GO
Isoform 2 (identifier: P33981-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: Missing.

Note: No experimental confirmation available.
Show »
Length:856
Mass (Da):96,944
Checksum:i13FDD345AE1B52DA
GO

Sequence cautioni

The sequence AAA61239 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB87580 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti389S → A in AAA61239 (PubMed:1639825).Curated1
Sequence conflicti768L → V in CAA49912 (PubMed:7678926).Curated1
Sequence conflicti768L → V (PubMed:1956325).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03714197A → V.Corresponds to variant rs2230513dbSNPEnsembl.1
Natural variantiVAR_037142758D → N.Corresponds to variant rs2230512dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043072420Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86699 mRNA. Translation: AAA61239.1. Different initiation.
AK292460 mRNA. Translation: BAF85149.1.
AK315696 mRNA. Translation: BAG38059.1.
AL133475 Genomic DNA. Translation: CAB87580.1. Different initiation.
CH471051 Genomic DNA. Translation: EAW48699.1.
CH471051 Genomic DNA. Translation: EAW48700.1.
BC000633 mRNA. Translation: AAH00633.1.
BC032858 mRNA. Translation: AAH32858.1.
X70500 mRNA. Translation: CAA49912.1.
CCDSiCCDS4993.1. [P33981-1]
CCDS55040.1. [P33981-2]
PIRiA42861.
RefSeqiNP_001160163.1. NM_001166691.1. [P33981-2]
NP_003309.2. NM_003318.4. [P33981-1]
XP_011534401.1. XM_011536099.2. [P33981-1]
XP_011534402.1. XM_011536100.2. [P33981-2]
UniGeneiHs.169840.

Genome annotation databases

EnsembliENST00000230510; ENSP00000230510; ENSG00000112742. [P33981-2]
ENST00000369798; ENSP00000358813; ENSG00000112742. [P33981-1]
ENST00000509894; ENSP00000422936; ENSG00000112742. [P33981-2]
GeneIDi7272.
KEGGihsa:7272.
UCSCiuc003pjb.5. human. [P33981-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86699 mRNA. Translation: AAA61239.1. Different initiation.
AK292460 mRNA. Translation: BAF85149.1.
AK315696 mRNA. Translation: BAG38059.1.
AL133475 Genomic DNA. Translation: CAB87580.1. Different initiation.
CH471051 Genomic DNA. Translation: EAW48699.1.
CH471051 Genomic DNA. Translation: EAW48700.1.
BC000633 mRNA. Translation: AAH00633.1.
BC032858 mRNA. Translation: AAH32858.1.
X70500 mRNA. Translation: CAA49912.1.
CCDSiCCDS4993.1. [P33981-1]
CCDS55040.1. [P33981-2]
PIRiA42861.
RefSeqiNP_001160163.1. NM_001166691.1. [P33981-2]
NP_003309.2. NM_003318.4. [P33981-1]
XP_011534401.1. XM_011536099.2. [P33981-1]
XP_011534402.1. XM_011536100.2. [P33981-2]
UniGeneiHs.169840.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X9EX-ray3.10A514-828[»]
2ZMCX-ray3.14A510-857[»]
2ZMDX-ray2.88A510-857[»]
3CEKX-ray2.30A519-808[»]
3DBQX-ray2.70A515-857[»]
3GFWX-ray2.74A519-808[»]
3H9FX-ray2.60A519-808[»]
3HMNX-ray2.70A510-809[»]
3HMOX-ray2.40A510-809[»]
3HMPX-ray2.30A510-809[»]
3VQUX-ray2.40A516-820[»]
3W1FX-ray2.70A516-820[»]
3WYXX-ray2.90A516-820[»]
3WYYX-ray3.05A516-820[»]
3WZJX-ray2.75A516-820[»]
3WZKX-ray2.30A516-820[»]
4B94X-ray2.20A/B/C/D62-239[»]
4BHZX-ray2.85A519-808[»]
4BI0X-ray2.84A519-808[»]
4BI1X-ray2.70A519-808[»]
4BI2X-ray3.11A519-808[»]
4C4EX-ray2.60A519-808[»]
4C4FX-ray2.36A519-808[»]
4C4GX-ray2.65A519-808[»]
4C4HX-ray2.80A519-808[»]
4C4IX-ray2.65A519-808[»]
4C4JX-ray2.50A519-808[»]
4CV8X-ray3.00A519-808[»]
4CV9X-ray2.50A519-808[»]
4CVAX-ray2.50A519-808[»]
4D2SX-ray2.50A514-795[»]
4H7XX-ray2.60A/B55-210[»]
4H7YX-ray1.80A/B/C/D55-210[»]
4JS8X-ray1.94A515-795[»]
4JT3X-ray2.20A515-795[»]
4O6LX-ray2.38A/B515-795[»]
4ZEGX-ray2.33A515-795[»]
5AP0X-ray2.15A519-808[»]
5AP1X-ray2.05A519-808[»]
5AP2X-ray2.80A519-808[»]
5AP3X-ray2.70A519-808[»]
5AP4X-ray2.85A519-808[»]
5AP5X-ray2.80A519-808[»]
5AP6X-ray2.10A519-808[»]
5AP7X-ray2.45A519-808[»]
5EH0X-ray2.18A519-794[»]
5EHYX-ray2.26A519-808[»]
5EI2X-ray2.67A519-808[»]
5EI6X-ray2.01A519-808[»]
5EI8X-ray2.17A519-753[»]
5LJJX-ray3.00A519-808[»]
ProteinModelPortaliP33981.
SMRiP33981.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113123. 71 interactors.
DIPiDIP-40642N.
IntActiP33981. 35 interactors.
MINTiMINT-1203816.
STRINGi9606.ENSP00000358813.

Chemistry databases

BindingDBiP33981.
ChEMBLiCHEMBL3983.
GuidetoPHARMACOLOGYi2264.

PTM databases

iPTMnetiP33981.
PhosphoSitePlusiP33981.

Polymorphism and mutation databases

BioMutaiTTK.
DMDMi160112977.

Proteomic databases

EPDiP33981.
MaxQBiP33981.
PaxDbiP33981.
PeptideAtlasiP33981.
PRIDEiP33981.

Protocols and materials databases

DNASUi7272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230510; ENSP00000230510; ENSG00000112742. [P33981-2]
ENST00000369798; ENSP00000358813; ENSG00000112742. [P33981-1]
ENST00000509894; ENSP00000422936; ENSG00000112742. [P33981-2]
GeneIDi7272.
KEGGihsa:7272.
UCSCiuc003pjb.5. human. [P33981-1]

Organism-specific databases

CTDi7272.
DisGeNETi7272.
GeneCardsiTTK.
HGNCiHGNC:12401. TTK.
HPAiCAB010166.
CAB013229.
HPA016834.
MIMi604092. gene.
neXtProtiNX_P33981.
OpenTargetsiENSG00000112742.
PharmGKBiPA37066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0596. Eukaryota.
ENOG410XRRQ. LUCA.
GeneTreeiENSGT00790000123008.
HOGENOMiHOG000013174.
HOVERGENiHBG001029.
InParanoidiP33981.
KOiK08866.
OMAiMSCFRTP.
OrthoDBiEOG091G0GP7.
PhylomeDBiP33981.
TreeFamiTF105420.

Enzyme and pathway databases

BioCyciZFISH:HS03614-MONOMER.
BRENDAi2.7.12.1. 2681.
SignaLinkiP33981.
SIGNORiP33981.

Miscellaneous databases

EvolutionaryTraceiP33981.
GeneWikiiTTK_(gene).
GenomeRNAii7272.
PROiP33981.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112742.
CleanExiHS_TTK.
ExpressionAtlasiP33981. baseline and differential.
GenevisibleiP33981. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR027084. Dual_sp_prot_kinse_Ttk.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR22974:SF21. PTHR22974:SF21. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTK_HUMAN
AccessioniPrimary (citable) accession number: P33981
Secondary accession number(s): A8K8U5
, B2RDW2, E1P543, Q15272, Q5TCS0, Q9BW51, Q9NTM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.