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Protein

Heme-binding protein A

Gene

hbpA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Important role in heme acquisition or metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi3.A.1.5.27. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein A
Alternative name(s):
Hemin-binding lipoprotein
Gene namesi
Name:hbpA
Synonyms:dppA
Ordered Locus Names:HI_0853
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane 1 Publication; Lipid-anchor PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
ChainiPRO_000003179019 – 547Heme-binding protein AAdd BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi19N-palmitoyl cysteineCurated1
Lipidationi19S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0853.

Structurei

3D structure databases

ProteinModelPortaliP33950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
KOiK12368.
OMAiFETDFWI.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKATLTLA AATLVLAACD QSSSANKSTA QTEAKSSSNN TFVYCTAKAP
60 70 80 90 100
LGFSPALIIE GTSYNASSQQ VYNRLVEFKK GSTDIEPALA ESWEISDDGL
110 120 130 140 150
SYTFHLRKGV KFHTTKEFTP TRDFNADDVV FSFQRQLDPN HPYHNVSKGT
160 170 180 190 200
YPYFKAMKFP ELLKSVEKVD DNTIRITLNK TDATFLASLG MDFISIYSAE
210 220 230 240 250
YADSMLKAGK PETLDSRPVG TGPFVFVDYK TDQAIQYVAH ENYWKGRTPL
260 270 280 290 300
DRLVISIVPD ATTRYAKLQA GTCDLILFPN VADLAKMKTD PKVQLLEQKG
310 320 330 340 350
LNVAYIAFNT EKAPFDNVKV RQALNYAVDK KAIIEAVYQG AGTSAKNPLP
360 370 380 390 400
PTIWSYNDEI QDYPYDPEKA KQLLAEAGYP NGFETDFWIQ PVIRASNPNP
410 420 430 440 450
KRMAELIMAD WAKIGVKTNP VTYEWADYRK RAKEGELTAG IFGWSGDNGD
460 470 480 490 500
PDNFLSPLLG SSNIGNSNMA RFNNSEFDAL LNEAIGLTNK EERAKLYKQA
510 520 530 540
QVIVHNQAPW IPVAHSVGFA PLSPRVKGYV QSPFGYDAFY GVSVDGK
Length:547
Mass (Da):60,661
Last modified:November 1, 1995 - v2
Checksum:i7755E2164A40CB31
GO

Sequence cautioni

The sequence AAC22512 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti48 – 49KA → NS in strain: DL42. 2
Natural varianti181T → N in strain: DL42. 1
Natural varianti240H → N in strain: DL42. 1
Natural varianti343T → I in strain: DL42. 1
Natural varianti375A → V in strain: DL42. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88134 Genomic DNA. Translation: AAA73214.1. Sequence problems.
M84028 Genomic DNA. Translation: AAA24962.1.
L42023 Genomic DNA. Translation: AAC22512.1. Different initiation.
PIRiD64098.
T45066.
RefSeqiNP_439013.1. NC_000907.1.
WP_010869071.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22512; AAC22512; HI_0853.
GeneIDi949866.
KEGGihin:HI0853.
PATRICi20190361. VBIHaeInf48452_0894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88134 Genomic DNA. Translation: AAA73214.1. Sequence problems.
M84028 Genomic DNA. Translation: AAA24962.1.
L42023 Genomic DNA. Translation: AAC22512.1. Different initiation.
PIRiD64098.
T45066.
RefSeqiNP_439013.1. NC_000907.1.
WP_010869071.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP33950.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI0853.

Protein family/group databases

TCDBi3.A.1.5.27. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC22512; AAC22512; HI_0853.
GeneIDi949866.
KEGGihin:HI0853.
PATRICi20190361. VBIHaeInf48452_0894.

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
KOiK12368.
OMAiFETDFWI.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBPA_HAEIN
AccessioniPrimary (citable) accession number: P33950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.