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Protein

ER lumen protein-retaining receptor 2

Gene

KDELR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.

GO - Molecular functioni

  • KDEL sequence binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 2
Alternative name(s):
ERD2-like protein 1
Short name:
ELP-1
KDEL endoplasmic reticulum protein retention receptor 2
Short name:
KDEL receptor 2
Gene namesi
Name:KDELR2
Synonyms:ERD2.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6305. KDELR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22LumenalSequence analysis
Transmembranei3 – 2119HelicalSequence analysisAdd
BLAST
Topological domaini22 – 3514CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5318HelicalSequence analysisAdd
BLAST
Topological domaini54 – 618LumenalSequence analysis
Transmembranei62 – 8019HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9616CytoplasmicSequence analysisAdd
BLAST
Transmembranei97 – 11014HelicalSequence analysisAdd
BLAST
Topological domaini111 – 1177LumenalSequence analysis
Transmembranei118 – 13720HelicalSequence analysisAdd
BLAST
Topological domaini138 – 14912CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 16819HelicalSequence analysisAdd
BLAST
Topological domaini169 – 17810LumenalSequence analysis
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 21213CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cis-Golgi network Source: Ensembl
  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: ProtInc
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: ProtInc
  • transport vesicle Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30084.

Polymorphism and mutation databases

BioMutaiKDELR2.
DMDMi462018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212ER lumen protein-retaining receptor 2PRO_0000194155Add
BLAST

Proteomic databases

EPDiP33947.
MaxQBiP33947.
PaxDbiP33947.
PeptideAtlasiP33947.
PRIDEiP33947.
TopDownProteomicsiP33947-1. [P33947-1]
P33947-2. [P33947-2]

PTM databases

iPTMnetiP33947.
PhosphoSiteiP33947.
SwissPalmiP33947.

Expressioni

Gene expression databases

BgeeiENSG00000136240.
CleanExiHS_KDELR2.
ExpressionAtlasiP33947. baseline and differential.
GenevisibleiP33947. HS.

Organism-specific databases

HPAiHPA016459.
HPA047440.

Interactioni

Protein-protein interaction databases

BioGridi116204. 8 interactions.
IntActiP33947. 7 interactions.
MINTiMINT-3013452.
STRINGi9606.ENSP00000258739.

Structurei

3D structure databases

ProteinModelPortaliP33947.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiP33947.
KOiK10949.
OMAiINWIWRF.
OrthoDBiEOG091G0Q1H.
PhylomeDBiP33947.
TreeFamiTF314792.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P33947-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD
60 70 80 90 100
LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,422
Last modified:February 1, 1994 - v1
Checksum:i81BECB983E503142
GO
Isoform 2 (identifier: P33947-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-212: ILWTFSIYLE...LKGKKLSLPA → YSRERSSVCQ...AEEKSQKVSV

Show »
Length:186
Mass (Da):21,242
Checksum:iB7224397F0243996
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti137 – 1371M → V in AAH12994 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 21295ILWTF…LSLPA → YSRERSSVCQHKCQRPSPAS VLQGARTEFLPQQRHKMLDT ENQKLNSFVADSHQWLCKNA EEKSQKVSV in isoform 2. 1 PublicationVSP_036712Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63745 mRNA. Translation: CAA45277.1.
M88458 mRNA. No translation available.
AC072052 Genomic DNA. Translation: AAS02002.1.
AK315702 mRNA. Translation: BAG38064.1.
CH236963 Genomic DNA. Translation: EAL23722.1.
CH878731 Genomic DNA. Translation: EAW55030.1.
BC008081 mRNA. Translation: AAH08081.1.
BC012994 mRNA. Translation: AAH12994.1.
BC071982 mRNA. Translation: AAH71982.1.
CCDSiCCDS43550.1. [P33947-2]
CCDS5351.1. [P33947-1]
PIRiA42286.
RefSeqiNP_001094073.1. NM_001100603.1. [P33947-2]
NP_006845.1. NM_006854.3. [P33947-1]
UniGeneiHs.654552.

Genome annotation databases

EnsembliENST00000258739; ENSP00000258739; ENSG00000136240. [P33947-1]
ENST00000490996; ENSP00000420501; ENSG00000136240. [P33947-2]
GeneIDi11014.
KEGGihsa:11014.
UCSCiuc003sqe.5. human. [P33947-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63745 mRNA. Translation: CAA45277.1.
M88458 mRNA. No translation available.
AC072052 Genomic DNA. Translation: AAS02002.1.
AK315702 mRNA. Translation: BAG38064.1.
CH236963 Genomic DNA. Translation: EAL23722.1.
CH878731 Genomic DNA. Translation: EAW55030.1.
BC008081 mRNA. Translation: AAH08081.1.
BC012994 mRNA. Translation: AAH12994.1.
BC071982 mRNA. Translation: AAH71982.1.
CCDSiCCDS43550.1. [P33947-2]
CCDS5351.1. [P33947-1]
PIRiA42286.
RefSeqiNP_001094073.1. NM_001100603.1. [P33947-2]
NP_006845.1. NM_006854.3. [P33947-1]
UniGeneiHs.654552.

3D structure databases

ProteinModelPortaliP33947.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116204. 8 interactions.
IntActiP33947. 7 interactions.
MINTiMINT-3013452.
STRINGi9606.ENSP00000258739.

PTM databases

iPTMnetiP33947.
PhosphoSiteiP33947.
SwissPalmiP33947.

Polymorphism and mutation databases

BioMutaiKDELR2.
DMDMi462018.

Proteomic databases

EPDiP33947.
MaxQBiP33947.
PaxDbiP33947.
PeptideAtlasiP33947.
PRIDEiP33947.
TopDownProteomicsiP33947-1. [P33947-1]
P33947-2. [P33947-2]

Protocols and materials databases

DNASUi11014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258739; ENSP00000258739; ENSG00000136240. [P33947-1]
ENST00000490996; ENSP00000420501; ENSG00000136240. [P33947-2]
GeneIDi11014.
KEGGihsa:11014.
UCSCiuc003sqe.5. human. [P33947-1]

Organism-specific databases

CTDi11014.
GeneCardsiKDELR2.
H-InvDBHIX0021543.
HGNCiHGNC:6305. KDELR2.
HPAiHPA016459.
HPA047440.
MIMi609024. gene.
neXtProtiNX_P33947.
PharmGKBiPA30084.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiP33947.
KOiK10949.
OMAiINWIWRF.
OrthoDBiEOG091G0Q1H.
PhylomeDBiP33947.
TreeFamiTF314792.

Enzyme and pathway databases

ReactomeiR-HSA-6807878. COPI-mediated anterograde transport.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

GeneWikiiKDELR2.
GenomeRNAii11014.
PROiP33947.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136240.
CleanExiHS_KDELR2.
ExpressionAtlasiP33947. baseline and differential.
GenevisibleiP33947. HS.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERD22_HUMAN
AccessioniPrimary (citable) accession number: P33947
Secondary accession number(s): A4D2P4, Q6IPC5, Q96E30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.