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Protein

ER lumen protein-retaining receptor 1

Gene

KDELR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 1
Alternative name(s):
KDEL endoplasmic reticulum protein retention receptor 1
Short name:
KDEL receptor 1
Gene namesi
Name:KDELR1
Synonyms:KDELR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22LumenalSequence analysis
Transmembranei3 – 2119HelicalSequence analysisAdd
BLAST
Topological domaini22 – 3514CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5318HelicalSequence analysisAdd
BLAST
Topological domaini54 – 618LumenalSequence analysis
Transmembranei62 – 8019HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9616CytoplasmicSequence analysisAdd
BLAST
Transmembranei97 – 11014HelicalSequence analysisAdd
BLAST
Topological domaini111 – 1177LumenalSequence analysis
Transmembranei118 – 13720HelicalSequence analysisAdd
BLAST
Topological domaini138 – 14912CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 16819HelicalSequence analysisAdd
BLAST
Topological domaini169 – 17810LumenalSequence analysis
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 21213CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212ER lumen protein-retaining receptor 1PRO_0000194152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei209 – 2091Phosphoserine; by PKABy similarity

Post-translational modificationi

Phosphorylation by PKA at Ser-209 is required for ER retention function.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP33946.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004463.

Interactioni

Subunit structurei

Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005857.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiP33946.
KOiK10949.
OMAiAPFELLW.
OrthoDBiEOG091G0Q1H.
TreeFamiTF314792.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFRFLGDL SHLLAIILLL LKIWKSRSCA GISGKSQVLF AVVFTARYLD
60 70 80 90 100
LFTNYISLYN TCMKVVYIAC SFTTVWMIYS KFKATYDGNH DTFRVEFLVI
110 120 130 140 150
PTAILAFLVN HDFTPLEILW TFSIYLESVA ILPQLFMVSK TGEAETITSH
160 170 180 190 200
YLFALGVYRT LYLFNWIWRY HFEGFFDLIA IVAGLVQTVL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,574
Last modified:October 17, 2006 - v2
Checksum:i9E0EE32BF14B8C20
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771M → L no nucleotide entry (PubMed:8380600).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118250 mRNA. Translation: AAI18251.1.
PIRiA44394.
RefSeqiNP_001069963.1. NM_001076495.1.
UniGeneiBt.37666.

Genome annotation databases

EnsembliENSBTAT00000005857; ENSBTAP00000005857; ENSBTAG00000004463.
GeneIDi618184.
KEGGibta:618184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118250 mRNA. Translation: AAI18251.1.
PIRiA44394.
RefSeqiNP_001069963.1. NM_001076495.1.
UniGeneiBt.37666.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005857.

Proteomic databases

PaxDbiP33946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005857; ENSBTAP00000005857; ENSBTAG00000004463.
GeneIDi618184.
KEGGibta:618184.

Organism-specific databases

CTDi10945.

Phylogenomic databases

eggNOGiKOG3106. Eukaryota.
COG5196. LUCA.
GeneTreeiENSGT00390000004010.
HOGENOMiHOG000231400.
HOVERGENiHBG001398.
InParanoidiP33946.
KOiK10949.
OMAiAPFELLW.
OrthoDBiEOG091G0Q1H.
TreeFamiTF314792.

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Gene expression databases

BgeeiENSBTAG00000004463.

Family and domain databases

InterProiIPR000133. ER_ret_rcpt.
[Graphical view]
PANTHERiPTHR10585. PTHR10585. 1 hit.
PfamiPF00810. ER_lumen_recept. 1 hit.
[Graphical view]
PRINTSiPR00660. ERLUMENR.
PROSITEiPS00951. ER_LUMEN_RECEPTOR_1. 1 hit.
PS00952. ER_LUMEN_RECEPTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERD21_BOVIN
AccessioniPrimary (citable) accession number: P33946
Secondary accession number(s): Q17QP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.