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Protein

ABC transporter ATP-binding/permease protein YojI

Gene

yojI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi356 – 363ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • microcin transport Source: EcoliWiki
  • response to antibiotic Source: EcoCyc

Keywordsi

Biological processAntibiotic resistance, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:YOJI-MONOMER

Protein family/group databases

TCDBi3.A.1.113.3 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter ATP-binding/permease protein YojICurated
Gene namesi
Name:yojI
Synonyms:yojJ
Ordered Locus Names:b2211, JW2199
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12070 yojI

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei47 – 67HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei125 – 145HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei149 – 169HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei240 – 260HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei270 – 290HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Disruption increases sensitivity of cells to microcin J25.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000931961 – 547ABC transporter ATP-binding/permease protein YojIAdd BLAST547

Proteomic databases

PaxDbiP33941
PRIDEiP33941

Interactioni

Protein-protein interaction databases

BioGridi4261919, 159 interactors
IntActiP33941, 5 interactors
STRINGi316385.ECDH10B_2368

Structurei

3D structure databases

ProteinModelPortaliP33941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 291ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST277
Domaini323 – 547ABC transporterPROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105IBP Bacteria
COG4615 LUCA
HOGENOMiHOG000260219
InParanoidiP33941
KOiK06159
OMAiGWADTAV
PhylomeDBiP33941

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005898 Cyc_pep_transpt
IPR027417 P-loop_NTPase
PANTHERiPTHR43553:SF11 PTHR43553:SF11, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR01194 cyc_pep_trnsptr, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P33941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLVLVWRQ YRWPFISVMA LSLASAALGI GLIAFINQRL IETADTSLLV
60 70 80 90 100
LPEFLGLLLL LMAVTLGSQL ALTTLGHHFV YRLRSEFIKR ILDTHVERIE
110 120 130 140 150
QLGSASLLAG LTSDVRNITI AFVRLPELVQ GIILTIGSAA YLWMLSGKML
160 170 180 190 200
LVTAIWMAIT IWGGFVLVAR VYKHMATLRE TEDKLYTDFQ TVLEGRKELT
210 220 230 240 250
LNRERAEYVF NNLYIPDAQE YRHHIIRADT FHLSAVNWSN IMMLGAIGLV
260 270 280 290 300
FWMANSLGWA DTNVAATYSL TLLFLRTPLL SAVGALPTLL TAQVAFNKLN
310 320 330 340 350
KFALAPFKAE FPRPQAFPNW QTLELRNVTF AYQDNAFSVG PINLTIKRGE
360 370 380 390 400
LLFLIGGNGS GKSTLAMLLT GLYQPQSGEI LLDGKPVSGE QPEDYRKLFS
410 420 430 440 450
AVFTDVWLFD QLLGPEGKPA NPQLVEKWLA QLKMAHKLEL SNGRIVNLKL
460 470 480 490 500
SKGQKKRVAL LLALAEERDI ILLDEWAADQ DPHFRREFYQ VLLPLMQEMG
510 520 530 540
KTIFAISHDD HYFIHADRLL EMRNGQLSEL TGEERDAASR DAVARTA
Length:547
Mass (Da):61,553
Last modified:June 1, 1994 - v2
Checksum:i11523935EDFD9EAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16403.1
U00096 Genomic DNA Translation: AAC75271.1
AP009048 Genomic DNA Translation: BAA15994.1
PIRiA64991
RefSeqiNP_416715.1, NC_000913.3
WP_000422182.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75271; AAC75271; b2211
BAA15994; BAA15994; BAA15994
GeneIDi946705
KEGGiecj:JW2199
eco:b2211
PATRICifig|1411691.4.peg.24

Similar proteinsi

Entry informationi

Entry nameiYOJI_ECOLI
AccessioniPrimary (citable) accession number: P33941
Secondary accession number(s): P33942
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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