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Protein

Malate:quinone oxidoreductase

Gene

mqo

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).
Proteins known to be involved in this subpathway in this organism are:
  1. Malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: EcoCyc
  • malate dehydrogenase (menaquinone) activity Source: UniProtKB-EC
  • malate dehydrogenase (quinone) activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciEcoCyc:EG12069-MONOMER
MetaCyc:EG12069-MONOMER
UniPathwayiUPA00223; UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Malate:quinone oxidoreductase (EC:1.1.5.4)
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene namesi
Name:mqo
Synonyms:yojH
Ordered Locus Names:b2210, JW2198
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12069 mqo

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic side of plasma membrane Source: EcoCyc
  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287121 – 548Malate:quinone oxidoreductaseAdd BLAST548

Proteomic databases

PaxDbiP33940
PRIDEiP33940

Interactioni

Protein-protein interaction databases

BioGridi4262217, 4 interactors
IntActiP33940, 18 interactors
STRINGi316385.ECDH10B_2367

Structurei

3D structure databases

ProteinModelPortaliP33940
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.Curated

Phylogenomic databases

eggNOGiENOG4105DWT Bacteria
COG0579 LUCA
HOGENOMiHOG000109379
InParanoidiP33940
KOiK00116
OMAiEPIAATK
PhylomeDBiP33940

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

P33940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVTAMLFS MAVGLNAVSM AAKAKASEEQ ETDVLLIGGG IMSATLGTYL
60 70 80 90 100
RELEPEWSMT MVERLEGVAQ ESSNGWNNAG TGHSALMELN YTPQNADGSI
110 120 130 140 150
SIEKAVAINE AFQISRQFWA HQVERGVLRT PRSFINTVPH MSFVWGEDNV
160 170 180 190 200
NFLRARYAAL QQSSLFRGMR YSEDHAQIKE WAPLVMEGRD PQQKVAATRT
210 220 230 240 250
EIGTDVNYGE ITRQLIASLQ KKSNFSLQLS SEVRALKRND DNTWTVTVAD
260 270 280 290 300
LKNGTAQNIR AKFVFIGAGG AALKLLQESG IPEAKDYAGF PVGGQFLVSE
310 320 330 340 350
NPDVVNHHLA KVYGKASVGA PPMSVPHIDT RVLDGKRVVL FGPFATFSTK
360 370 380 390 400
FLKNGSLWDL MSSTTTSNVM PMMHVGLDNF DLVKYLVSQV MLSEEDRFEA
410 420 430 440 450
LKEYYPQAKK EDWRLWQAGQ RVQIIKRDAE KGGVLRLGTE VVSDQQGTIA
460 470 480 490 500
ALLGASPGAS TAAPIMLNLL EKVFGDRVSS PQWQATLKAI VPSYGRKLNG
510 520 530 540
DVAATERELQ YTSEVLGLNY DKPQAADSTP KPQLKPQPVQ KEVADIAL
Length:548
Mass (Da):60,230
Last modified:November 1, 1997 - v2
Checksum:i3278A6D124EEE2AA
GO

Sequence cautioni

The sequence AAA16402 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16402.1 Different initiation.
U00096 Genomic DNA Translation: AAC75270.1
AP009048 Genomic DNA Translation: BAA15993.1
PIRiH64990
RefSeqiNP_416714.1, NC_000913.3
WP_000758077.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75270; AAC75270; b2210
BAA15993; BAA15993; BAA15993
GeneIDi946702
KEGGiecj:JW2198
eco:b2210
PATRICifig|1411691.4.peg.25

Similar proteinsi

Entry informationi

Entry nameiMQO_ECOLI
AccessioniPrimary (citable) accession number: P33940
Secondary accession number(s): O08017, P76454
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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