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Protein

Ferredoxin-type protein NapH

Gene

napH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in electron transfer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi226Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi229Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi232Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi236Iron-sulfur 1 (4Fe-4S)By similarity1
Metal bindingi260Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi263Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi266Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi270Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:NAPH-MONOMER.
ECOL316407:JW2192-MONOMER.
MetaCyc:NAPH-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin-type protein NapH
Gene namesi
Name:napH
Synonyms:yejZ
Ordered Locus Names:b2204, JW2192
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12062. napH.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: EcoliWiki
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001592831 – 287Ferredoxin-type protein NapHAdd BLAST287

Proteomic databases

PaxDbiP33934.
PRIDEiP33934.

Interactioni

Protein-protein interaction databases

BioGridi4262223. 10 interactors.
DIPiDIP-10310N.
IntActiP33934. 2 interactors.
MINTiMINT-1276100.
STRINGi511145.b2204.

Structurei

3D structure databases

ProteinModelPortaliP33934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 2474Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST31
Domaini251 – 2804Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105GXZ. Bacteria.
COG0348. LUCA.
HOGENOMiHOG000275510.
InParanoidiP33934.
KOiK02574.
OMAiCPVGAFY.
PhylomeDBiP33934.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011886. NapH_MauN.
[Graphical view]
PfamiPF13237. Fer4_10. 1 hit.
PF12801. Fer4_5. 2 hits.
[Graphical view]
TIGRFAMsiTIGR02163. napH_. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRKRDAGR EALEKKGWWR SHRWLVLRRL CQFFVLGMFL SGPWFGVWIL
60 70 80 90 100
HGNYSSSLLF DTVPLTDPLM TLQSLASGHL PATVALTGAV IITVLYALAG
110 120 130 140 150
KRLFCSWVCP LNPITDLANW LRRRFDLNQS ATIPRHIRYV LLVVILVGSA
160 170 180 190 200
LTGTLIWEWI NPVSLMGRSL VMGFGSGALL ILALFLFDLL VVEHGWCGHI
210 220 230 240 250
CPVGALYGVL GSKGVITVAA TDRQKCNRCM DCFHVCPEPH VLRAPVLDEQ
260 270 280
SPVQVTSRDC MTCGRCVDVC SEDVFTITTR WSSGAKS
Length:287
Mass (Da):31,874
Last modified:February 1, 1994 - v1
Checksum:i50AF7D5E0FFBC4D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16396.1.
U00096 Genomic DNA. Translation: AAC75264.1.
AP009048 Genomic DNA. Translation: BAE76667.1.
PIRiB64990.
RefSeqiNP_416708.1. NC_000913.3.
WP_000013515.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75264; AAC75264; b2204.
BAE76667; BAE76667; BAE76667.
GeneIDi945984.
KEGGiecj:JW2192.
eco:b2204.
PATRICi32119767. VBIEscCol129921_2293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16396.1.
U00096 Genomic DNA. Translation: AAC75264.1.
AP009048 Genomic DNA. Translation: BAE76667.1.
PIRiB64990.
RefSeqiNP_416708.1. NC_000913.3.
WP_000013515.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP33934.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262223. 10 interactors.
DIPiDIP-10310N.
IntActiP33934. 2 interactors.
MINTiMINT-1276100.
STRINGi511145.b2204.

Proteomic databases

PaxDbiP33934.
PRIDEiP33934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75264; AAC75264; b2204.
BAE76667; BAE76667; BAE76667.
GeneIDi945984.
KEGGiecj:JW2192.
eco:b2204.
PATRICi32119767. VBIEscCol129921_2293.

Organism-specific databases

EchoBASEiEB1992.
EcoGeneiEG12062. napH.

Phylogenomic databases

eggNOGiENOG4105GXZ. Bacteria.
COG0348. LUCA.
HOGENOMiHOG000275510.
InParanoidiP33934.
KOiK02574.
OMAiCPVGAFY.
PhylomeDBiP33934.

Enzyme and pathway databases

BioCyciEcoCyc:NAPH-MONOMER.
ECOL316407:JW2192-MONOMER.
MetaCyc:NAPH-MONOMER.

Miscellaneous databases

PROiP33934.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR011886. NapH_MauN.
[Graphical view]
PfamiPF13237. Fer4_10. 1 hit.
PF12801. Fer4_5. 2 hits.
[Graphical view]
TIGRFAMsiTIGR02163. napH_. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAPH_ECOLI
AccessioniPrimary (citable) accession number: P33934
Secondary accession number(s): Q2MAN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.