Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene

ccmA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATPUniRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled Source: EcoCyc
  • ATP binding Source: UniProtKB-KW
  • heme-transporting ATPase activity Source: UniProtKB-EC
  • protoheme IX ABC transporter activity Source: UniProtKB-EC

GO - Biological processi

  • cytochrome complex assembly Source: UniProtKB-KW
  • heme transport Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Biological processCytochrome c-type biogenesis, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CCMA-MONOMER
MetaCyc:CCMA-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:3.6.3.41UniRule annotation)
Alternative name(s):
Heme exporter protein AUniRule annotation
Gene namesi
Name:ccmAUniRule annotation
Synonyms:yejW
Ordered Locus Names:b2201, JW5366
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12059 ccmA

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • extrinsic component of cytoplasmic side of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000921771 – 207Cytochrome c biogenesis ATP-binding export protein CcmAAdd BLAST207

Proteomic databases

PaxDbiP33931
PRIDEiP33931

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).UniRule annotation

Protein-protein interaction databases

BioGridi4261550, 10 interactors
IntActiP33931, 3 interactors
STRINGi316385.ECDH10B_2358

Structurei

3D structure databases

ProteinModelPortaliP33931
SMRiP33931
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 207ABC transporterUniRule annotationAdd BLAST204

Sequence similaritiesi

Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EV4 Bacteria
COG4133 LUCA
InParanoidiP33931
KOiK02193
OMAiYRPIWIL
PhylomeDBiP33931

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005895 ABC_transptr_haem_export_CcmA
IPR027417 P-loop_NTPase
PANTHERiPTHR43499 PTHR43499, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01189 ccmA, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51243 CCMA, 1 hit

Sequencei

Sequence statusi: Complete.

P33931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMLEARELL CERDERTLFS GLSFTLNAGE WVQITGSNGA GKTTLLRLLT
60 70 80 90 100
GLSRPDAGEV LWQGQPLHQV RDSYHQNLLW IGHQPGIKTR LTALENLHFY
110 120 130 140 150
HRDGDTAQCL EALAQAGLAG FEDIPVNQLS AGQQRRVALA RLWLTRATLW
160 170 180 190 200
ILDEPFTAID VNGVDRLTQR MAQHTEQGGI VILTTHQPLN VAESKIRRIS

LTQTRAA
Length:207
Mass (Da):23,053
Last modified:December 1, 2000 - v2
Checksum:i73224210C6FAEC4A
GO

Sequence cautioni

The sequence AAA16393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16393.1 Different initiation.
U00096 Genomic DNA Translation: AAC75261.2
AP009048 Genomic DNA Translation: BAE76664.1
PIRiG64989
RefSeqiNP_416705.2, NC_000913.3
WP_000525587.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75261; AAC75261; b2201
BAE76664; BAE76664; BAE76664
GeneIDi946714
KEGGiecj:JW5366
eco:b2201
PATRICifig|511145.12.peg.2290

Similar proteinsi

Entry informationi

Entry nameiCCMA_ECOLI
AccessioniPrimary (citable) accession number: P33931
Secondary accession number(s): Q2MAP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health