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Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene

ccmA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATPUniRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled Source: EcoCyc
  • ATP binding Source: UniProtKB-KW
  • heme-transporting ATPase activity Source: UniProtKB-EC
  • protoheme IX ABC transporter activity Source: UniProtKB-EC

GO - Biological processi

  • cytochrome complex assembly Source: UniProtKB-KW
  • heme transport Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Biological processCytochrome c-type biogenesis, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CCMA-MONOMER.
MetaCyc:CCMA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:3.6.3.41UniRule annotation)
Alternative name(s):
Heme exporter protein AUniRule annotation
Gene namesi
Name:ccmAUniRule annotation
Synonyms:yejW
Ordered Locus Names:b2201, JW5366
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12059. ccmA.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000921771 – 207Cytochrome c biogenesis ATP-binding export protein CcmAAdd BLAST207

Proteomic databases

PaxDbiP33931.
PRIDEiP33931.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).UniRule annotation

Protein-protein interaction databases

BioGridi4261550. 10 interactors.
IntActiP33931. 3 interactors.
STRINGi511145.b2201.

Structurei

3D structure databases

ProteinModelPortaliP33931.
SMRiP33931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 207ABC transporterUniRule annotationAdd BLAST204

Sequence similaritiesi

Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EV4. Bacteria.
COG4133. LUCA.
InParanoidiP33931.
KOiK02193.
OMAiRWDSEAI.
PhylomeDBiP33931.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01189. ccmA. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.

Sequencei

Sequence statusi: Complete.

P33931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMLEARELL CERDERTLFS GLSFTLNAGE WVQITGSNGA GKTTLLRLLT
60 70 80 90 100
GLSRPDAGEV LWQGQPLHQV RDSYHQNLLW IGHQPGIKTR LTALENLHFY
110 120 130 140 150
HRDGDTAQCL EALAQAGLAG FEDIPVNQLS AGQQRRVALA RLWLTRATLW
160 170 180 190 200
ILDEPFTAID VNGVDRLTQR MAQHTEQGGI VILTTHQPLN VAESKIRRIS

LTQTRAA
Length:207
Mass (Da):23,053
Last modified:December 1, 2000 - v2
Checksum:i73224210C6FAEC4A
GO

Sequence cautioni

The sequence AAA16393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16393.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75261.2.
AP009048 Genomic DNA. Translation: BAE76664.1.
PIRiG64989.
RefSeqiNP_416705.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC75261; AAC75261; b2201.
BAE76664; BAE76664; BAE76664.
GeneIDi946714.
KEGGiecj:JW5366.
eco:b2201.
PATRICi32119761. VBIEscCol129921_2290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA. Translation: AAA16393.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75261.2.
AP009048 Genomic DNA. Translation: BAE76664.1.
PIRiG64989.
RefSeqiNP_416705.2. NC_000913.3.

3D structure databases

ProteinModelPortaliP33931.
SMRiP33931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261550. 10 interactors.
IntActiP33931. 3 interactors.
STRINGi511145.b2201.

Proteomic databases

PaxDbiP33931.
PRIDEiP33931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75261; AAC75261; b2201.
BAE76664; BAE76664; BAE76664.
GeneIDi946714.
KEGGiecj:JW5366.
eco:b2201.
PATRICi32119761. VBIEscCol129921_2290.

Organism-specific databases

EchoBASEiEB1989.
EcoGeneiEG12059. ccmA.

Phylogenomic databases

eggNOGiENOG4107EV4. Bacteria.
COG4133. LUCA.
InParanoidiP33931.
KOiK02193.
OMAiRWDSEAI.
PhylomeDBiP33931.

Enzyme and pathway databases

BioCyciEcoCyc:CCMA-MONOMER.
MetaCyc:CCMA-MONOMER.

Miscellaneous databases

PROiP33931.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01189. ccmA. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCMA_ECOLI
AccessioniPrimary (citable) accession number: P33931
Secondary accession number(s): Q2MAP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 1, 2000
Last modified: February 15, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.