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P33912

- BPA1_STRAU

UniProt

P33912 - BPA1_STRAU

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Protein
Non-haem bromoperoxidase BPO-A1
Gene
N/A
Organism
Streptomyces aureofaciens
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be a chlorinating enzyme involved in 7-chlorotetracycline biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951 By similarity
Active sitei224 – 2241 By similarity
Active sitei253 – 2531 By similarity

GO - Molecular functioni

  1. peroxidase activity Source: UniProtKB-KW

GO - Biological processi

  1. antibiotic biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Antibiotic biosynthesis

Protein family/group databases

MEROPSiS33.992.
PeroxiBasei5911. STaHalNPrx01.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-haem bromoperoxidase BPO-A1 (EC:1.11.1.-)
Alternative name(s):
BPO1
Bromide peroxidase
Encoded oniPlasmid0 Publication
OrganismiStreptomyces aureofaciens
Taxonomic identifieri1894 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 275274Non-haem bromoperoxidase BPO-A1
PRO_0000207066Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53
Beta strandi11 – 177
Beta strandi19 – 268
Helixi33 – 364
Helixi37 – 459
Beta strandi49 – 535
Helixi70 – 8314
Beta strandi88 – 947
Helixi97 – 10812
Beta strandi113 – 1208
Helixi138 – 16326
Turni164 – 1674
Helixi175 – 18511
Helixi190 – 20213
Helixi206 – 2094
Beta strandi216 – 2216
Beta strandi225 – 2273
Helixi229 – 2313
Helixi233 – 2397
Beta strandi244 – 2485
Turni253 – 2575
Helixi261 – 27313

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A8QX-ray1.75A2-275[»]
ProteinModelPortaliP33912.
SMRiP33912. Positions 2-275.

Miscellaneous databases

EvolutionaryTraceiP33912.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33912-1 [UniParc]FASTAAdd to Basket

« Hide

MPICTTRDGV EIFYKDWGQG RPVVFIHGWP LNGDAWQDQL KAVVDAGYRG    50
IAHDRRGHGH STPVWDGYDF DTFADDLNDL LTDLDLRDVT LVAHSMGGGE 100
LARYVGRHGT GRLRSAVLLS AIPPVMIKSD KNPDGVPDEV FDALKNGVLT 150
ERSQFWKDTA EGFFSANRPG NKVTQGNKDA FWYMAMAQTI EGGVRCVDAF 200
GYTDFTEDLK KFDIPTLVVH GDDDQVVPID ATGRKSAQII PNAELKVYEG 250
SSHGIAMVPG DKEKFNRDLL EFLNK 275
Length:275
Mass (Da):30,475
Last modified:January 23, 2007 - v3
Checksum:iAA2F6A958C58406E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41C → S AA sequence 1 Publication
Sequence conflicti17 – 171W → D AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01096 Genomic DNA. Translation: AAC43253.1.
PIRiS59929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U01096 Genomic DNA. Translation: AAC43253.1 .
PIRi S59929.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A8Q X-ray 1.75 A 2-275 [» ]
ProteinModelPortali P33912.
SMRi P33912. Positions 2-275.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S33.992.
PeroxiBasei 5911. STaHalNPrx01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P33912.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
[Graphical view ]
PRINTSi PR00111. ABHYDROLASE.
PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of a second non-haem bromoperoxidase gene from Streptomyces aureofaciens ATCC 10762: sequence analysis, expression in Streptomyces lividans and enzyme purification."
    Pelletier I., Pfeifer O., Altenbuchner J., van Pee K.-P.
    Microbiology 140:509-516(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10762 / CCM 3239 / DSM 40127 / JCM 4008 / LMG 5968.
  2. "Purification, characterization and comparison of two non-haem bromoperoxidases from Streptomyces aureofaciens ATCC 10762."
    Weng M., Pfeifer O., Krauss S., Lingens F., van Pee K.-H.
    J. Gen. Microbiol. 137:2539-2546(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
    Strain: ATCC 10762 / CCM 3239 / DSM 40127 / JCM 4008 / LMG 5968.
  3. "Structural investigation of the cofactor-free chloroperoxidases."
    Hofmann B., Tolzer S., Pelletier I., Altenbuchner J., van Pee K.-H., Hecht H.-J.
    J. Mol. Biol. 279:889-900(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS).

Entry informationi

Entry nameiBPA1_STRAU
AccessioniPrimary (citable) accession number: P33912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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