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Protein

Transcriptional activator protein TraR

Gene

traR

Organism
Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulation of conjugal transfer of Ti plasmids. TraR activates target genes in the presence of AAI and also activates traR and traI themselves.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi191 – 21020H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Conjugation, Quorum sensing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein TraR
Gene namesi
Name:traR
Encoded oniPlasmid pTiA6NC0 Publication
OrganismiRhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
Taxonomic identifieri358 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Transcriptional activator protein TraRPRO_0000184192Add
BLAST

Expressioni

Gene expression databases

CollecTFiEXPREG_00000a40.

Interactioni

Chemistry

BindingDBiP33905.

Structurei

Secondary structure

1
234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 118Combined sources
Helixi18 – 3114Combined sources
Beta strandi35 – 439Combined sources
Beta strandi46 – 516Combined sources
Helixi55 – 639Combined sources
Helixi66 – 683Combined sources
Helixi71 – 788Combined sources
Beta strandi83 – 864Combined sources
Helixi87 – 904Combined sources
Turni91 – 933Combined sources
Helixi96 – 10611Combined sources
Turni107 – 1093Combined sources
Beta strandi111 – 1199Combined sources
Helixi121 – 1233Combined sources
Beta strandi125 – 13612Combined sources
Helixi145 – 16117Combined sources
Beta strandi167 – 1693Combined sources
Helixi176 – 18510Combined sources
Turni186 – 1883Combined sources
Helixi191 – 1988Combined sources
Helixi202 – 21615Combined sources
Helixi221 – 23010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H0MX-ray3.00A/B/C/D1-234[»]
1L3LX-ray1.66A/B/C/D1-234[»]
DisProtiDP00198.
ProteinModelPortaliP33905.
SMRiP33905. Positions 2-234.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33905.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 23266HTH luxR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK19732.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHWLDKLTD LAAIEGDECI LKTGLADIAD HFGFTGYAYL HIQHRHITAV
60 70 80 90 100
TNYHRQWQST YFDKKFEALD PVVKRARSRK HIFTWSGEHE RPTLSKDERA
110 120 130 140 150
FYDHASDFGI RSGITIPIKT ANGFMSMFTM ASDKPVIDLD REIDAVAAAA
160 170 180 190 200
TIGQIHARIS FLRTTPTAED AAWLDPKEAT YLRWIAVGKT MEEIADVEGV
210 220 230
KYNSVRVKLR EAMKRFDVRS KAHLTALAIR RKLI
Length:234
Mass (Da):26,734
Last modified:July 15, 1999 - v2
Checksum:i1B0AEC296F1521A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08596 Genomic DNA. Translation: AAA64793.1. Sequence problems.
AF242881 Genomic DNA. Translation: AAC28121.1.
RefSeqiNP_059701.1. NC_002377.1.
WP_010892389.1. NZ_CP011249.1.

Genome annotation databases

GeneIDi1224220.
KEGGipg:1224220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08596 Genomic DNA. Translation: AAA64793.1. Sequence problems.
AF242881 Genomic DNA. Translation: AAC28121.1.
RefSeqiNP_059701.1. NC_002377.1.
WP_010892389.1. NZ_CP011249.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H0MX-ray3.00A/B/C/D1-234[»]
1L3LX-ray1.66A/B/C/D1-234[»]
DisProtiDP00198.
ProteinModelPortaliP33905.
SMRiP33905. Positions 2-234.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP33905.
ChEMBLiCHEMBL5865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1224220.
KEGGipg:1224220.

Phylogenomic databases

KOiK19732.

Miscellaneous databases

EvolutionaryTraceiP33905.

Gene expression databases

CollecTFiEXPREG_00000a40.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid conjugal transfer in the presence of a plant tumor metabolite."
    Fuqua W.C. Jr., Winans S.C.
    J. Bacteriol. 176:2796-2806(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A348.
  2. Winans S.C.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiTRAR_RHIRD
AccessioniPrimary (citable) accession number: P33905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 15, 1999
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.