P33904 (TRAI_RHIRD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-homoserine-lactone synthase
EC=2.3.1.184

Alternative name(s):
Autoinducer synthesis protein TraI

Gene names

Name:

traI

Encoded on

Plasmid pTiA6NC

Organism

Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)

Taxonomic identifier

358 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium › Agrobacterium tumefaciens complex

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-homoserine lactone), an autoinducer molecule which binds to TraR and thus acts in the control of conjugal transfer.
Catalytic activity	An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine = [acyl-carrier-protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone.
Sequence similarities	Belongs to the autoinducer synthase family.

Ontologies

Keywords
Biological process	Autoinducer synthesis Conjugation Quorum sensing
Molecular function	Transferase
Technical term	Plasmid
Gene Ontology (GO)
Biological_process	conjugation Inferred from electronic annotation. Source: UniProtKB-KW quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Acyl-homoserine-lactone synthase		PRO_0000210899

Sequences

	Sequence		Length	Mass (Da)
	P33904 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: E1D6D772E2A9F7C2	FASTA	212	23,412
	10 20 30 40 50 60 MLILTVSPDQ YQHQNSYLKQ MHRLRAEVFG NRLKWDVAIE DGGERDQYDE LSPTYILATF 70 80 90 100 110 120 GGQRVVGCAR LLAPSGPTML ERTFPQLLAT GSLSATTAMI ETSRFCVDTT LPTGRAGRQL 130 140 150 160 170 180 HLATLTMFAG IIEWSMANGY DEIVTATDLR FERILKRAGW PMTRLGEPVA IGNTVAVAGH 190 200 210 LPADRKSFER VCPPGYRSII ADDNGRPLRS AA

References

[1]	"A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid conjugal transfer in the presence of a plant tumor metabolite." Fuqua W.C. Jr., Winans S.C. J. Bacteriol. 176:2796-2806(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A348.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L17024 Genomic DNA. Translation: AAA64792.1. AF242881 Genomic DNA. Translation: AAB95104.1.
RefSeq	NP_059761.1. NC_002377.1.
3D structure databases
ProteinModelPortal	P33904.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1224280.
Phylogenomic databases
ProtClustDB	PRK13834.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001690. Autoind_synth. IPR018311. Autoind_synth_CS. [Graphical view]
Pfam	PF00765. Autoind_synth. 1 hit. [Graphical view]
PRINTS	PR01549. AUTOINDCRSYN.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS00949. AUTOINDUCER_SYNTH_1. 1 hit. PS51187. AUTOINDUCER_SYNTH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRAI_RHIRD

Accession

Primary (citable) accession number: P33904

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program