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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

ATP1B3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

Potassium, Sodium

Enzyme and pathway databases

ReactomeiR-GGA-5578775. Ion homeostasis.
R-GGA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Gene namesi
Name:ATP1B3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence analysisAdd
BLAST
Transmembranei38 – 6225Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini63 – 280218ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Sodium/potassium-transporting ATPase subunit beta-3PRO_0000219111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi128 ↔ 145By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi155 ↔ 171By similarity
Disulfide bondi192 ↔ 251By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP33879.
PRIDEiP33879.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004355.

Structurei

3D structure databases

ProteinModelPortaliP33879.
SMRiP33879. Positions 32-77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP33879.
KOiK01540.
OMAiSDIPKYR.
OrthoDBiEOG7M6D85.
PhylomeDBiP33879.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKETKKPFR QSVAEWRQFV YNPNSGEFLG RTAKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWV MLQTLSNDIP KYRDRISSPG LMISPKPDTA LEFYFNKSDA
110 120 130 140 150
QSYAEYVSTL RKFLETYDDS KQSQNINCTP GKVFDQNDVA VKKACRFNLS
160 170 180 190 200
ELGQCSGKED KTFGYSKGTP CVLVKMNRII GLKPEGEPYI QCTSKEPGAV
210 220 230 240 250
EINYFPSGGL IDLMYFPYYG KTLHAHYLQP LVAVQLAINS NSTNEEIAIE
260 270 280
CKILGSPNLK NEDDRDKFLG RIAFKVEMTE
Length:280
Mass (Da):31,859
Last modified:February 1, 1994 - v1
Checksum:i48928F19CA4B701B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13208 mRNA. Translation: AAA02625.1.
PIRiI50396.
RefSeqiNP_990866.1. NM_205535.1.
UniGeneiGga.42003.

Genome annotation databases

EnsembliENSGALT00000004364; ENSGALP00000004355; ENSGALG00000002764.
GeneIDi396549.
KEGGigga:396549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13208 mRNA. Translation: AAA02625.1.
PIRiI50396.
RefSeqiNP_990866.1. NM_205535.1.
UniGeneiGga.42003.

3D structure databases

ProteinModelPortaliP33879.
SMRiP33879. Positions 32-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004355.

Proteomic databases

PaxDbiP33879.
PRIDEiP33879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000004364; ENSGALP00000004355; ENSGALG00000002764.
GeneIDi396549.
KEGGigga:396549.

Organism-specific databases

CTDi483.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP33879.
KOiK01540.
OMAiSDIPKYR.
OrthoDBiEOG7M6D85.
PhylomeDBiP33879.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-GGA-5578775. Ion homeostasis.
R-GGA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

NextBioi20816585.
PROiP33879.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of DNA encoding an avian Na+,K(+)-ATPase beta 2-subunit."
    Lemas M., Fambrough D.M.
    Biochim. Biophys. Acta 1149:339-342(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.
    Tissue: Brain.

Entry informationi

Entry nameiAT1B3_CHICK
AccessioniPrimary (citable) accession number: P33879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be the beta-2 subunit.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.