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Protein

Sodium/potassium-transporting ATPase subunit beta-3

Gene

ATP1B3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport
LigandPotassium, Sodium

Enzyme and pathway databases

ReactomeiR-GGA-5578775. Ion homeostasis.
R-GGA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3
Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Gene namesi
Name:ATP1B3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST25
Topological domaini63 – 280ExtracellularSequence analysisAdd BLAST218

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191111 – 280Sodium/potassium-transporting ATPase subunit beta-3Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 145By similarity
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 171By similarity
Disulfide bondi192 ↔ 251By similarity
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP33879.
PRIDEiP33879.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiENSGALG00000002764.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004355.

Structurei

3D structure databases

ProteinModelPortaliP33879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP33879.
KOiK01540.
OMAiQNINCTP.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP33879.
TreeFamiTF314618.

Family and domain databases

InterProiView protein in InterPro
IPR000402. Na/K_ATPase_sub_beta.
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiView protein in Pfam
PF00287. Na_K-ATPase. 1 hit.
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiView protein in PROSITE
PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P33879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKETKKPFR QSVAEWRQFV YNPNSGEFLG RTAKSWGLIL LFYLVFYGFL
60 70 80 90 100
AALFTFTMWV MLQTLSNDIP KYRDRISSPG LMISPKPDTA LEFYFNKSDA
110 120 130 140 150
QSYAEYVSTL RKFLETYDDS KQSQNINCTP GKVFDQNDVA VKKACRFNLS
160 170 180 190 200
ELGQCSGKED KTFGYSKGTP CVLVKMNRII GLKPEGEPYI QCTSKEPGAV
210 220 230 240 250
EINYFPSGGL IDLMYFPYYG KTLHAHYLQP LVAVQLAINS NSTNEEIAIE
260 270 280
CKILGSPNLK NEDDRDKFLG RIAFKVEMTE
Length:280
Mass (Da):31,859
Last modified:February 1, 1994 - v1
Checksum:i48928F19CA4B701B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13208 mRNA. Translation: AAA02625.1.
PIRiI50396.
RefSeqiNP_990866.1. NM_205535.1.
UniGeneiGga.42003.

Genome annotation databases

EnsembliENSGALT00000056315; ENSGALP00000054148; ENSGALG00000002764.
GeneIDi396549.
KEGGigga:396549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13208 mRNA. Translation: AAA02625.1.
PIRiI50396.
RefSeqiNP_990866.1. NM_205535.1.
UniGeneiGga.42003.

3D structure databases

ProteinModelPortaliP33879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004355.

Proteomic databases

PaxDbiP33879.
PRIDEiP33879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000056315; ENSGALP00000054148; ENSGALG00000002764.
GeneIDi396549.
KEGGigga:396549.

Organism-specific databases

CTDi483.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP33879.
KOiK01540.
OMAiQNINCTP.
OrthoDBiEOG091G0DJ4.
PhylomeDBiP33879.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-GGA-5578775. Ion homeostasis.
R-GGA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiPR:P33879.

Gene expression databases

BgeeiENSGALG00000002764.

Family and domain databases

InterProiView protein in InterPro
IPR000402. Na/K_ATPase_sub_beta.
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiView protein in Pfam
PF00287. Na_K-ATPase. 1 hit.
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiView protein in PROSITE
PS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B3_CHICK
AccessioniPrimary (citable) accession number: P33879
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 10, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be the beta-2 subunit.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.