P33879 (AT1B3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3

Gene names

Name:

ATP1B3

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Predominantly expressed in brain.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.
Caution	Was originally (Ref.1) thought to be the beta-2 subunit.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Sodium/potassium-transporting ATPase subunit beta-3		PRO_0000219111
Regions
	Topological domain	1 – 37	37	Cytoplasmic Potential
	Transmembrane	38 – 62	25	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	63 – 280	218	Extracellular Potential
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
	Glycosylation	148	1	N-linked (GlcNAc...) Potential
	Glycosylation	241	1	N-linked (GlcNAc...) Potential
	Disulfide bond	128 ↔ 145		By similarity
	Disulfide bond	155 ↔ 171		By similarity
	Disulfide bond	192 ↔ 251		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P33879 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 48928F19CA4B701B	FASTA	280	31,859
	10 20 30 40 50 60 MSKETKKPFR QSVAEWRQFV YNPNSGEFLG RTAKSWGLIL LFYLVFYGFL AALFTFTMWV 70 80 90 100 110 120 MLQTLSNDIP KYRDRISSPG LMISPKPDTA LEFYFNKSDA QSYAEYVSTL RKFLETYDDS 130 140 150 160 170 180 KQSQNINCTP GKVFDQNDVA VKKACRFNLS ELGQCSGKED KTFGYSKGTP CVLVKMNRII 190 200 210 220 230 240 GLKPEGEPYI QCTSKEPGAV EINYFPSGGL IDLMYFPYYG KTLHAHYLQP LVAVQLAINS 250 260 270 280 NSTNEEIAIE CKILGSPNLK NEDDRDKFLG RIAFKVEMTE

References

[1]	"Sequence analysis of DNA encoding an avian Na+,K(+)-ATPase beta 2-subunit." Lemas M., Fambrough D.M. Biochim. Biophys. Acta 1149:339-342(1993) [PubMed: 8391844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: White leghorn. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13208 mRNA. Translation: AAA02625.1.
IPI	IPI00580874.
PIR	I50396.
RefSeq	NP_990866.1. NM_205535.1.
UniGene	Gga.42003.
3D structure databases
ProteinModelPortal	P33879.
SMR	P33879. Positions 32-77.
ModBase	Search...
Proteomic databases
PRIDE	P33879.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000004364; ENSGALP00000004355; ENSGALG00000002764.
GeneID	396549.
KEGG	gga:396549.
Organism-specific databases
CTD	483.
Phylogenomic databases
eggNOG	veNOG04988.
GeneTree	ENSGT00550000074530.
HOGENOM	HBG446583.
HOVERGEN	HBG050603.
InParanoid	P33879.
OMA	LMISPKP.
OrthoDB	EOG447FTQ.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
KO	K01540.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT1B3_CHICK

Accession

Primary (citable) accession number: P33879

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	November 16, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program