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P33826

- DUT_VAR67

UniProt

P33826 - DUT_VAR67

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
DUT, C6L, E2L, F2L
Organism
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
ORF Names:C6L, E2L, F2L
OrganismiVariola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Taxonomic identifieri587200 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002060: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182943Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP33826.
SMRiP33826. Positions 7-131.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

P33826-1 [UniParc]FASTAAdd to Basket

« Hide

MFNMNINSPV RFVKETNRAK SPTRQSPYAA GYDLYSAYDY TIPPGERQLI    50
KTDISMSMPK FCYGRIAPRS GLSLKGIDIG GGVIDEDYRG NIGVILINNG 100
KYTFNVNTGD RIAQLIYQRI YYPELKEVQS LDSTDRGDQG FGSTGLR 147
Length:147
Mass (Da):16,465
Last modified:February 1, 1994 - v1
Checksum:iD918ED4F482ECDA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69198 Genomic DNA. Translation: CAA48967.1.
L22579 Genomic DNA. Translation: AAA60774.1.
U18340 Genomic DNA. Translation: AAA69437.1.
U18337 Genomic DNA. Translation: AAA69331.1.
U18338 Genomic DNA. Translation: AAA69372.1.
Y16780 Genomic DNA. Translation: CAB54626.1.
PIRiF36839.
H72153.
T28464.
RefSeqiNP_042070.1. NC_001611.1.

Genome annotation databases

GeneIDi1486386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69198 Genomic DNA. Translation: CAA48967.1 .
L22579 Genomic DNA. Translation: AAA60774.1 .
U18340 Genomic DNA. Translation: AAA69437.1 .
U18337 Genomic DNA. Translation: AAA69331.1 .
U18338 Genomic DNA. Translation: AAA69372.1 .
Y16780 Genomic DNA. Translation: CAB54626.1 .
PIRi F36839.
H72153.
T28464.
RefSeqi NP_042070.1. NC_001611.1.

3D structure databases

ProteinModelPortali P33826.
SMRi P33826. Positions 7-131.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1486386.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms."
    Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.
    FEBS Lett. 319:80-83(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: India-1967 / Isolate Ind3.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bangladesh-1975.
  3. Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M., Totmenin A.V., Shchelkunov S.N., Esposito J.J.
    Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Congo-1965, Garcia-1966 and Somalia-1977.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Garcia-1966.

Entry informationi

Entry nameiDUT_VAR67
AccessioniPrimary (citable) accession number: P33826
Secondary accession number(s): Q76Q48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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