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P33826

- DUT_VAR67

UniProt

P33826 - DUT_VAR67

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:DUT
    ORF Names:C6L, E2L, F2L
    OrganismiVariola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
    Taxonomic identifieri587200 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000002060: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182943Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP33826.
    SMRiP33826. Positions 7-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P33826-1 [UniParc]FASTAAdd to Basket

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    MFNMNINSPV RFVKETNRAK SPTRQSPYAA GYDLYSAYDY TIPPGERQLI    50
    KTDISMSMPK FCYGRIAPRS GLSLKGIDIG GGVIDEDYRG NIGVILINNG 100
    KYTFNVNTGD RIAQLIYQRI YYPELKEVQS LDSTDRGDQG FGSTGLR 147
    Length:147
    Mass (Da):16,465
    Last modified:February 1, 1994 - v1
    Checksum:iD918ED4F482ECDA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69198 Genomic DNA. Translation: CAA48967.1.
    L22579 Genomic DNA. Translation: AAA60774.1.
    U18340 Genomic DNA. Translation: AAA69437.1.
    U18337 Genomic DNA. Translation: AAA69331.1.
    U18338 Genomic DNA. Translation: AAA69372.1.
    Y16780 Genomic DNA. Translation: CAB54626.1.
    PIRiF36839.
    H72153.
    T28464.
    RefSeqiNP_042070.1. NC_001611.1.

    Genome annotation databases

    GeneIDi1486386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69198 Genomic DNA. Translation: CAA48967.1 .
    L22579 Genomic DNA. Translation: AAA60774.1 .
    U18340 Genomic DNA. Translation: AAA69437.1 .
    U18337 Genomic DNA. Translation: AAA69331.1 .
    U18338 Genomic DNA. Translation: AAA69372.1 .
    Y16780 Genomic DNA. Translation: CAB54626.1 .
    PIRi F36839.
    H72153.
    T28464.
    RefSeqi NP_042070.1. NC_001611.1.

    3D structure databases

    ProteinModelPortali P33826.
    SMRi P33826. Positions 7-131.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1486386.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms."
      Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.
      FEBS Lett. 319:80-83(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: India-1967 / Isolate Ind3.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Bangladesh-1975.
    3. Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M., Totmenin A.V., Shchelkunov S.N., Esposito J.J.
      Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Congo-1965, Garcia-1966 and Somalia-1977.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Garcia-1966.

    Entry informationi

    Entry nameiDUT_VAR67
    AccessioniPrimary (citable) accession number: P33826
    Secondary accession number(s): Q76Q48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3