Reviewed, UniProtKB/Swiss-Prot P33821 (VE10_VARV)

Names and origin

Protein names

Recommended name:
    Probable FAD-linked sulfhydryl oxidase E10
    EC=1.8.3.2

Gene names

ORF Names:

E10R

Organism

Variola virus

Taxonomic identifier

10255 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity.
Catalytic activity	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
Cofactor	FAD By similarity.
Sequence similarities	Belongs to the poxviruses E10 family. Contains 1 ERV/ALR sulfhydryl oxidase domain.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	thiol oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 95	95	Probable FAD-linked sulfhydryl oxidase E10		PRO_0000099466
Regions
	Domain	1 – 95	95	ERV/ALR sulfhydryl oxidase
Amino acid modifications
	Disulfide bond	43 ↔ 46		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	P33821-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 9BCB0B4306397E27	FASTA	95	10,836
	10 20 30 40 50 60 MNPKHWGRAA WTIIFIVLSQ AGLDGNIEAC KRKLYTIVST LPCPACRRHA TIAIEDNNIM 70 80 90 SSNDLNYIYY FFIRLFNNLA SDPKYAIDVS KVKPL

References

[1]	"Analysis of the nucleotide sequence of a 43 kbp segment of the genome of variola virus India-1967 strain." Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., Sandakhchiev L.S. Virus Res. 30:239-258(1993) [PubMed: 8109158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: India-1967 / Isolate Ind3.
[2]	"Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms." Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S. FEBS Lett. 319:80-83(1993) [PubMed: 8384129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: India-1967 / Isolate Ind3.
[3]	"Potential virulence determinants in terminal regions of variola smallpox virus genome." Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C., Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A., Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C. Nature 366:748-751(1993) [PubMed: 8264798] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Bangladesh-1975.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69198 Genomic DNA. Translation: CAA48992.1. L22579 Genomic DNA. Translation: AAA60799.1.
PIR	A72157. D36842. T28489.
RefSeq	NP_042095.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1486405.
Enzyme and pathway databases
BRENDA	1.8.3.2. 288297.
Family and domain databases
InterPro	IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006890. Sulphydryl_Oase_FAD-link_ERV1. [Graphical view]
Pfam	PF04805. Pox_E10. 1 hit. [Graphical view]
PIRSF	PIRSF015696. VAC_E10R. 1 hit.
PROSITE	PS51324. ERV_ALR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VE10_VARV

Accession

Primary (citable) accession number: P33821

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	November 24, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)