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P33809 (PAP1_VAR67) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase catalytic subunit

EC=2.7.7.19
Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L
VP55
Gene names
Name:PAPL
ORF Names:C1L, E1L
OrganismVariola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) [Reference proteome]
Taxonomic identifier587200 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.

Sequence similarities

Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Poly(A) polymerase catalytic subunit
PRO_0000099108

Sites

Active site2021 By similarity
Active site2041 By similarity

Natural variations

Natural variant101F → L in strain: Bangladesh-1975 and Garcia-1966.
Natural variant1101N → D in strain: Bangladesh-1975 and Garcia-1966.

Sequences

Sequence LengthMass (Da)Tools
P33809 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 5118681BFC93DDE1

FASTA47955,586
        10         20         30         40         50         60 
MNRNPDHNTF PNITLKIIET YLGRLPSVNE YHMLKLQTRN IQKITVFNKD IFVSLVKKNK 

        70         80         90        100        110        120 
KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL QSVLVTTYTN ILGVLTIKAP 

       130        140        150        160        170        180 
NVISSKISYN VTSMEELARD MLNSMNVAVI DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN 

       190        200        210        220        230        240 
KSCICYGSYS LYLINPNIRY GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY 

       250        260        270        280        290        300 
MVIKDENDNH IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 

       310        320        330        340        350        360 
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRVVTVTTKD YFSFKKCLVY 

       370        380        390        400        410        420 
LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF SNTILLSDKG KVHEISARGL 

       430        440        450        460        470 
CAHILLYQML TSGAYKQCLS DLLNSMMNRD KIPIYSHTER DKKHGRHGFI NIEKDIIVF 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of a 43 kbp segment of the genome of variola virus India-1967 strain."
Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., Sandakhchiev L.S.
Virus Res. 30:239-258(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: India-1967 / Isolate Ind3.
[2]"Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms."
Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.
FEBS Lett. 319:80-83(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: India-1967 / Isolate Ind3.
[3]"Potential virulence determinants in terminal regions of variola smallpox virus genome."
Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C., Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A., Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.
Nature 366:748-751(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Bangladesh-1975.
[4]"Alastrim smallpox variola minor virus genome DNA sequences."
Shchelkunov S.N., Totmenin A.V., Loparev V.N., Safronov P.F., Gutorov V.V., Chizhikov V.E., Knight J.C., Parsons J.M., Massung R.F., Esposito J.J.
Virology 266:361-386(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Garcia-1966.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69198 Genomic DNA. Translation: CAA48983.1.
L22579 Genomic DNA. Translation: AAA60790.1.
Y16780 Genomic DNA. Translation: CAB54642.1.
PIRD36841.
H72155.
T28480.
RefSeqNP_042086.1. NC_001611.1.

3D structure databases

ProteinModelPortalP33809.
SMRP33809. Positions 12-479.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1486407.

Family and domain databases

InterProIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFPIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNetSearch...

Entry information

Entry namePAP1_VAR67
AccessionPrimary (citable) accession number: P33809
Secondary accession number(s): Q76Q36, Q85370
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families