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P33809

- PAP1_VAR67

UniProt

P33809 - PAP1_VAR67

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Protein
Poly(A) polymerase catalytic subunit
Gene
PAPL, C1L, E1L
Organism
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021 By similarity
Active sitei204 – 2041 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
VP55
Gene namesi
Name:PAPL
ORF Names:C1L, E1L
OrganismiVariola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Taxonomic identifieri587200 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000002060: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Poly(A) polymerase catalytic subunit
PRO_0000099108Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.

Structurei

3D structure databases

ProteinModelPortaliP33809.
SMRiP33809. Positions 12-479.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

P33809-1 [UniParc]FASTAAdd to Basket

« Hide

MNRNPDHNTF PNITLKIIET YLGRLPSVNE YHMLKLQTRN IQKITVFNKD    50
IFVSLVKKNK KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL 100
QSVLVTTYTN ILGVLTIKAP NVISSKISYN VTSMEELARD MLNSMNVAVI 150
DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN KSCICYGSYS LYLINPNIRY 200
GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY MVIKDENDNH 250
IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 300
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRVVTVTTKD 350
YFSFKKCLVY LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF 400
SNTILLSDKG KVHEISARGL CAHILLYQML TSGAYKQCLS DLLNSMMNRD 450
KIPIYSHTER DKKHGRHGFI NIEKDIIVF 479
Length:479
Mass (Da):55,586
Last modified:February 1, 1994 - v1
Checksum:i5118681BFC93DDE1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101F → L in strain: Bangladesh-1975 and Garcia-1966.
Natural varianti110 – 1101N → D in strain: Bangladesh-1975 and Garcia-1966.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69198 Genomic DNA. Translation: CAA48983.1.
L22579 Genomic DNA. Translation: AAA60790.1.
Y16780 Genomic DNA. Translation: CAB54642.1.
PIRiD36841.
H72155.
T28480.
RefSeqiNP_042086.1. NC_001611.1.

Genome annotation databases

GeneIDi1486407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69198 Genomic DNA. Translation: CAA48983.1 .
L22579 Genomic DNA. Translation: AAA60790.1 .
Y16780 Genomic DNA. Translation: CAB54642.1 .
PIRi D36841.
H72155.
T28480.
RefSeqi NP_042086.1. NC_001611.1.

3D structure databases

ProteinModelPortali P33809.
SMRi P33809. Positions 12-479.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1486407.

Family and domain databases

InterProi IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view ]
Pfami PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of variola virus India-1967 strain."
    Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V., Sandakhchiev L.S.
    Virus Res. 30:239-258(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: India-1967 / Isolate Ind3.
  2. "Genes of variola and vaccinia viruses necessary to overcome the host protective mechanisms."
    Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.
    FEBS Lett. 319:80-83(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: India-1967 / Isolate Ind3.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bangladesh-1975.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Garcia-1966.

Entry informationi

Entry nameiPAP1_VAR67
AccessioniPrimary (citable) accession number: P33809
Secondary accession number(s): Q76Q36, Q85370
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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