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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202By similarity1
Active sitei204By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processmRNA processing, Transcription
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
VP55
Gene namesi
Name:PAPL
ORF Names:C1L, E1L
OrganismiVariola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Taxonomic identifieri587200 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000119805 Componenti: Genome
  • UP000111493 Componenti: Genome
  • UP000002060 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000991081 – 479Poly(A) polymerase catalytic subunitAdd BLAST479

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.

Structurei

3D structure databases

ProteinModelPortaliP33809.
SMRiP33809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK21315.
OrthoDBiVOG0900007K.

Family and domain databases

InterProiView protein in InterPro
IPR037265. PolyA_pol_cat_sf.
IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxviridae_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
PfamiView protein in Pfam
PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.
SUPFAMiSSF160957. SSF160957. 1 hit.

Sequencei

Sequence statusi: Complete.

P33809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRNPDHNTF PNITLKIIET YLGRLPSVNE YHMLKLQTRN IQKITVFNKD
60 70 80 90 100
IFVSLVKKNK KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL
110 120 130 140 150
QSVLVTTYTN ILGVLTIKAP NVISSKISYN VTSMEELARD MLNSMNVAVI
160 170 180 190 200
DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN KSCICYGSYS LYLINPNIRY
210 220 230 240 250
GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY MVIKDENDNH
260 270 280 290 300
IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK
310 320 330 340 350
DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRVVTVTTKD
360 370 380 390 400
YFSFKKCLVY LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF
410 420 430 440 450
SNTILLSDKG KVHEISARGL CAHILLYQML TSGAYKQCLS DLLNSMMNRD
460 470
KIPIYSHTER DKKHGRHGFI NIEKDIIVF
Length:479
Mass (Da):55,586
Last modified:February 1, 1994 - v1
Checksum:i5118681BFC93DDE1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti10F → L in strain: Bangladesh-1975 and Garcia-1966. 1
Natural varianti110N → D in strain: Bangladesh-1975 and Garcia-1966. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69198 Genomic DNA. Translation: CAA48983.1.
L22579 Genomic DNA. Translation: AAA60790.1.
Y16780 Genomic DNA. Translation: CAB54642.1.
PIRiD36841.
H72155.
T28480.
RefSeqiNP_042086.1. NC_001611.1.

Genome annotation databases

GeneIDi1486407.
KEGGivg:1486407.

Similar proteinsi

Entry informationi

Entry nameiPAP1_VAR67
AccessioniPrimary (citable) accession number: P33809
Secondary accession number(s): Q76Q36, Q85370
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families