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P33802

- KITH_AHV1W

UniProt

P33802 - KITH_AHV1W

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Protein

Thymidine kinase

Gene

TK

Organism
Alcelaphine herpesvirus type 1 (strain WC11) (AHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei270 – 2701Proton acceptorSequence Analysis
Binding sitei308 – 3081SubstrateBy similarity
Binding sitei355 – 3551SubstrateBy similarity
Binding sitei398 – 3981ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2508ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Synonyms:BXLF1
OrganismiAlcelaphine herpesvirus type 1 (strain WC11) (AHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri33705 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes gnou (Black wildebeest) [TaxID: 59528]
Connochaetes taurinus (Blue wildebeest) [TaxID: 9927]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Thymidine kinasePRO_0000175060Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP33802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P33802-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP
60 70 80 90 100
LLSVARRVEV QGVNPGLKPR GLVRPRQDAD NPSSDEGFDW ELWKLHLSTR
110 120 130 140 150
AFSFLEPPRL SSSNTASGLR SSCSDFTILG SSGVNPTSHA NLSEEEMYEE
160 170 180 190 200
IPPLASNPSD ERHPRQLSGA VAQGAIRKSP RKLKFKPAKF KGLSSSLLNP
210 220 230 240 250
FTASDSGRRA RRQTPTCQPG FTPIFQDLGE PHYVKACTVF FEGCMAAGKT
260 270 280 290 300
TLLNFARQTL SDDEALTIPE PMRFWTEVYT NVLSQIVKIN KECKPGKTST
310 320 330 340 350
TAELVSCQLK FATPLKTQSL FLQRSVKKDS EMQPVGPLDK WVIVDRHQLS
360 370 380 390 400
ALVVFPLVLM RRGMLSFSDF FNLLGMFEAH PGEVIALMSV NVEENFTRLK
410 420 430 440 450
KRGRVCERHI DRDYIKEIKG SFNAAYCAWL FLQYFSIQTT MQICMGLSSL
460 470 480 490 500
DEACATEGVC HTTASRIWNN RMLVTLSDII SQFSNDYTVQ NVCYNFFSQL
510 520 530 540 550
STLKFVVIDL SAFRHDVPGA WGEFYMQVMK NGDIKTRVMD FTAIKALADT
560 570 580 590 600
AHNTHLRSIS FSSSQVFSTM LFLILLCVTG AQAITTPAPP RPATTTPRRG
610 620 630 640 650
VTSAPLIVPA SSSELIVTLD GTFHSVTIDM TEIRQYVRQE IIEALWNASH
660 670 680
VFESLETTYN RYKDVYRFTD QSIRVNTRGS CQLVKK
Length:686
Mass (Da):77,074
Last modified:February 1, 1994 - v1
Checksum:i06A817D080826A5F
GO

Cross-referencesi

3D structure databases

ProteinModelPortali P33802.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a 3.5 kilobase fragment of malignant catarrhal fever virus strain WC11."
    Hsu D., Shih L.M., Zee Y.C.
    Arch. Virol. 113:53-60(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiKITH_AHV1W
AccessioniPrimary (citable) accession number: P33802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3