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P33802 (KITH_AHV1W) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length686 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 686686Thymidine kinase
PRO_0000175060

Regions

Nucleotide binding243 – 2508ATP By similarity

Sites

Active site2701Proton acceptor Potential
Binding site3081Substrate By similarity
Binding site3551Substrate By similarity
Binding site3981ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P33802 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 06A817D080826A5F

FASTA68677,074
        10         20         30         40         50         60 
MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP LLSVARRVEV 

        70         80         90        100        110        120 
QGVNPGLKPR GLVRPRQDAD NPSSDEGFDW ELWKLHLSTR AFSFLEPPRL SSSNTASGLR 

       130        140        150        160        170        180 
SSCSDFTILG SSGVNPTSHA NLSEEEMYEE IPPLASNPSD ERHPRQLSGA VAQGAIRKSP 

       190        200        210        220        230        240 
RKLKFKPAKF KGLSSSLLNP FTASDSGRRA RRQTPTCQPG FTPIFQDLGE PHYVKACTVF 

       250        260        270        280        290        300 
FEGCMAAGKT TLLNFARQTL SDDEALTIPE PMRFWTEVYT NVLSQIVKIN KECKPGKTST 

       310        320        330        340        350        360 
TAELVSCQLK FATPLKTQSL FLQRSVKKDS EMQPVGPLDK WVIVDRHQLS ALVVFPLVLM 

       370        380        390        400        410        420 
RRGMLSFSDF FNLLGMFEAH PGEVIALMSV NVEENFTRLK KRGRVCERHI DRDYIKEIKG 

       430        440        450        460        470        480 
SFNAAYCAWL FLQYFSIQTT MQICMGLSSL DEACATEGVC HTTASRIWNN RMLVTLSDII 

       490        500        510        520        530        540 
SQFSNDYTVQ NVCYNFFSQL STLKFVVIDL SAFRHDVPGA WGEFYMQVMK NGDIKTRVMD 

       550        560        570        580        590        600 
FTAIKALADT AHNTHLRSIS FSSSQVFSTM LFLILLCVTG AQAITTPAPP RPATTTPRRG 

       610        620        630        640        650        660 
VTSAPLIVPA SSSELIVTLD GTFHSVTIDM TEIRQYVRQE IIEALWNASH VFESLETTYN 

       670        680 
RYKDVYRFTD QSIRVNTRGS CQLVKK 

« Hide

References

[1]"Nucleotide sequence of a 3.5 kilobase fragment of malignant catarrhal fever virus strain WC11."
Hsu D., Shih L.M., Zee Y.C.
Arch. Virol. 113:53-60(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

3D structure databases

ProteinModelPortalP33802.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_AHV1W
AccessionPrimary (citable) accession number: P33802
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families