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Protein

Thymidine kinase

Gene

TK

Organism
Alcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei270 – 2701Proton acceptorSequence Analysis
Binding sitei308 – 3081SubstrateBy similarity
Binding sitei355 – 3551SubstrateBy similarity
Binding sitei398 – 3981ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi243 – 2508ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Synonyms:BXLF1
OrganismiAlcelaphine herpesvirus 1 (strain WC11) (AlHV-1) (Malignant catarrhal fever virus)
Taxonomic identifieri33705 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
Virus hostiConnochaetes gnou (Black wildebeest) [TaxID: 59528]
Connochaetes taurinus (Blue wildebeest) [TaxID: 9927]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Thymidine kinasePRO_0000175060Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP33802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P33802-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP
60 70 80 90 100
LLSVARRVEV QGVNPGLKPR GLVRPRQDAD NPSSDEGFDW ELWKLHLSTR
110 120 130 140 150
AFSFLEPPRL SSSNTASGLR SSCSDFTILG SSGVNPTSHA NLSEEEMYEE
160 170 180 190 200
IPPLASNPSD ERHPRQLSGA VAQGAIRKSP RKLKFKPAKF KGLSSSLLNP
210 220 230 240 250
FTASDSGRRA RRQTPTCQPG FTPIFQDLGE PHYVKACTVF FEGCMAAGKT
260 270 280 290 300
TLLNFARQTL SDDEALTIPE PMRFWTEVYT NVLSQIVKIN KECKPGKTST
310 320 330 340 350
TAELVSCQLK FATPLKTQSL FLQRSVKKDS EMQPVGPLDK WVIVDRHQLS
360 370 380 390 400
ALVVFPLVLM RRGMLSFSDF FNLLGMFEAH PGEVIALMSV NVEENFTRLK
410 420 430 440 450
KRGRVCERHI DRDYIKEIKG SFNAAYCAWL FLQYFSIQTT MQICMGLSSL
460 470 480 490 500
DEACATEGVC HTTASRIWNN RMLVTLSDII SQFSNDYTVQ NVCYNFFSQL
510 520 530 540 550
STLKFVVIDL SAFRHDVPGA WGEFYMQVMK NGDIKTRVMD FTAIKALADT
560 570 580 590 600
AHNTHLRSIS FSSSQVFSTM LFLILLCVTG AQAITTPAPP RPATTTPRRG
610 620 630 640 650
VTSAPLIVPA SSSELIVTLD GTFHSVTIDM TEIRQYVRQE IIEALWNASH
660 670 680
VFESLETTYN RYKDVYRFTD QSIRVNTRGS CQLVKK
Length:686
Mass (Da):77,074
Last modified:February 1, 1994 - v1
Checksum:i06A817D080826A5F
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP33802.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a 3.5 kilobase fragment of malignant catarrhal fever virus strain WC11."
    Hsu D., Shih L.M., Zee Y.C.
    Arch. Virol. 113:53-60(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiKITH_AHV1W
AccessioniPrimary (citable) accession number: P33802
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 4, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.