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P33802

- KITH_AHV1W

UniProt

P33802 - KITH_AHV1W

Protein

Thymidine kinase

Gene

TK

Organism
Alcelaphine herpesvirus type 1 (strain WC11) (AHV-1) (Malignant catarrhal fever virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei270 – 2701Proton acceptorSequence Analysis
    Binding sitei308 – 3081SubstrateBy similarity
    Binding sitei355 – 3551SubstrateBy similarity
    Binding sitei398 – 3981ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi243 – 2508ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    Synonyms:BXLF1
    OrganismiAlcelaphine herpesvirus type 1 (strain WC11) (AHV-1) (Malignant catarrhal fever virus)
    Taxonomic identifieri33705 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeMacavirus
    Virus hostiConnochaetes gnou (Black wildebeest) [TaxID: 59528]
    Connochaetes taurinus (Blue wildebeest) [TaxID: 9927]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 686686Thymidine kinasePRO_0000175060Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP33802.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P33802-1 [UniParc]FASTAAdd to Basket

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    MASNSHNNYN TPRRQNYDVP KAWEEDSLYE NIDFLTQPAV SSDTSEDEEP    50
    LLSVARRVEV QGVNPGLKPR GLVRPRQDAD NPSSDEGFDW ELWKLHLSTR 100
    AFSFLEPPRL SSSNTASGLR SSCSDFTILG SSGVNPTSHA NLSEEEMYEE 150
    IPPLASNPSD ERHPRQLSGA VAQGAIRKSP RKLKFKPAKF KGLSSSLLNP 200
    FTASDSGRRA RRQTPTCQPG FTPIFQDLGE PHYVKACTVF FEGCMAAGKT 250
    TLLNFARQTL SDDEALTIPE PMRFWTEVYT NVLSQIVKIN KECKPGKTST 300
    TAELVSCQLK FATPLKTQSL FLQRSVKKDS EMQPVGPLDK WVIVDRHQLS 350
    ALVVFPLVLM RRGMLSFSDF FNLLGMFEAH PGEVIALMSV NVEENFTRLK 400
    KRGRVCERHI DRDYIKEIKG SFNAAYCAWL FLQYFSIQTT MQICMGLSSL 450
    DEACATEGVC HTTASRIWNN RMLVTLSDII SQFSNDYTVQ NVCYNFFSQL 500
    STLKFVVIDL SAFRHDVPGA WGEFYMQVMK NGDIKTRVMD FTAIKALADT 550
    AHNTHLRSIS FSSSQVFSTM LFLILLCVTG AQAITTPAPP RPATTTPRRG 600
    VTSAPLIVPA SSSELIVTLD GTFHSVTIDM TEIRQYVRQE IIEALWNASH 650
    VFESLETTYN RYKDVYRFTD QSIRVNTRGS CQLVKK 686
    Length:686
    Mass (Da):77,074
    Last modified:February 1, 1994 - v1
    Checksum:i06A817D080826A5F
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P33802.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a 3.5 kilobase fragment of malignant catarrhal fever virus strain WC11."
      Hsu D., Shih L.M., Zee Y.C.
      Arch. Virol. 113:53-60(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiKITH_AHV1W
    AccessioniPrimary (citable) accession number: P33802
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3