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Protein

Global nitrogen regulator

Gene

ntcA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 131cNMPAdd BLAST123
DNA bindingi177 – 196H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Gene namesi
Name:ntcA
Ordered Locus Names:sll1423
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001871 – 225Global nitrogen regulatorAdd BLAST225

Proteomic databases

PRIDEiP33779.

Interactioni

Protein-protein interaction databases

IntActiP33779. 1 interactor.
STRINGi1148.SYNGTS_1435.

Structurei

3D structure databases

ProteinModelPortaliP33779.
SMRiP33779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 218HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Phylogenomic databases

HOGENOMiHOG000232503.
InParanoidiP33779.
OMAiTECEVAE.
PhylomeDBiP33779.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
PRINTSiPR00034. HTHCRP.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P33779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSLTQDRP LAAVFRRLGS ELMPPVVETF DRSKTIFFPG DPAERVYFLL
60 70 80 90 100
KGAVKLSRVY EAGEEITVAL LRENSVFGVL SLVTGQRSDR FYHAVAFTPV
110 120 130 140 150
ELLSAPIEQV EQALKEHPDL SLLMLQGLSS RILQTEMMIE TLAHRDMGSR
160 170 180 190 200
LVSFLLILCR DFGVPAPDGI RIDLKLSHQA IAEAIGSTRV TVTRLLGDLR
210 220
EGNMISITKK KITVHNPVAL SQQFT
Length:225
Mass (Da):25,046
Last modified:February 1, 1994 - v1
Checksum:iF1EE6555757E7379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71607 Genomic DNA. Translation: CAA50607.1.
BA000022 Genomic DNA. Translation: BAA18011.1.
PIRiA48640.

Genome annotation databases

EnsemblBacteriaiBAA18011; BAA18011; BAA18011.
KEGGisyn:sll1423.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNTCA_SYNY3
AccessioniPrimary (citable) accession number: P33779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 5, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names