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Protein

Global nitrogen regulator

Gene

ntcA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 131123cNMPAdd
BLAST
DNA bindingi177 – 19620H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Gene namesi
Name:ntcA
Ordered Locus Names:sll1423
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Global nitrogen regulatorPRO_0000100187Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP33779. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP33779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 21874HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000232503.
InParanoidiP33779.
OMAiTHEEIAC.
PhylomeDBiP33779.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSLTQDRP LAAVFRRLGS ELMPPVVETF DRSKTIFFPG DPAERVYFLL
60 70 80 90 100
KGAVKLSRVY EAGEEITVAL LRENSVFGVL SLVTGQRSDR FYHAVAFTPV
110 120 130 140 150
ELLSAPIEQV EQALKEHPDL SLLMLQGLSS RILQTEMMIE TLAHRDMGSR
160 170 180 190 200
LVSFLLILCR DFGVPAPDGI RIDLKLSHQA IAEAIGSTRV TVTRLLGDLR
210 220
EGNMISITKK KITVHNPVAL SQQFT
Length:225
Mass (Da):25,046
Last modified:February 1, 1994 - v1
Checksum:iF1EE6555757E7379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71607 Genomic DNA. Translation: CAA50607.1.
BA000022 Genomic DNA. Translation: BAA18011.1.
PIRiA48640.

Genome annotation databases

EnsemblBacteriaiBAA18011; BAA18011; BAA18011.
KEGGisyn:sll1423.
PATRICi23840032. VBISynSp132158_1576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71607 Genomic DNA. Translation: CAA50607.1.
BA000022 Genomic DNA. Translation: BAA18011.1.
PIRiA48640.

3D structure databases

ProteinModelPortaliP33779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP33779. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18011; BAA18011; BAA18011.
KEGGisyn:sll1423.
PATRICi23840032. VBISynSp132158_1576.

Phylogenomic databases

HOGENOMiHOG000232503.
InParanoidiP33779.
OMAiTHEEIAC.
PhylomeDBiP33779.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTCA_SYNY3
AccessioniPrimary (citable) accession number: P33779
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.