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P33779 (NTCA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Global nitrogen regulator
Gene names
Name:ntcA
Ordered Locus Names:sll1423
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 225225Global nitrogen regulator
PRO_0000100187

Regions

Domain145 – 21874HTH crp-type
Nucleotide binding9 – 131123cNMP
DNA binding177 – 19620H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
P33779 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F1EE6555757E7379

FASTA22525,046
        10         20         30         40         50         60 
MDQSLTQDRP LAAVFRRLGS ELMPPVVETF DRSKTIFFPG DPAERVYFLL KGAVKLSRVY 

        70         80         90        100        110        120 
EAGEEITVAL LRENSVFGVL SLVTGQRSDR FYHAVAFTPV ELLSAPIEQV EQALKEHPDL 

       130        140        150        160        170        180 
SLLMLQGLSS RILQTEMMIE TLAHRDMGSR LVSFLLILCR DFGVPAPDGI RIDLKLSHQA 

       190        200        210        220 
IAEAIGSTRV TVTRLLGDLR EGNMISITKK KITVHNPVAL SQQFT 

« Hide

References

« Hide 'large scale' references
[1]"General distribution of the nitrogen control gene ntcA in cyanobacteria."
Frias J.E., Merida A., Herrero A., Martin-Nieto J.M., Flores E.
J. Bacteriol. 175:5710-5713(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71607 Genomic DNA. Translation: CAA50607.1.
BA000022 Genomic DNA. Translation: BAA18011.1.
PIRA48640.
RefSeqNP_441331.1. NC_000911.1.
YP_005651388.1. NC_017277.1.
YP_007451213.1. NC_020286.1.

3D structure databases

ProteinModelPortalP33779.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP33779. 1 interaction.
STRING1148.sll1423.

Proteomic databases

PaxDbP33779.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18011; BAA18011; BAA18011.
GeneID12255807.
14616870.
954677.
KEGGsyn:sll1423.
syy:SYNGTS_1435.
syz:MYO_114480.
PATRIC23840032. VBISynSp132158_1576.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000232503.
OMARENSIFG.
OrthoDBEOG6QRWC5.
PhylomeDBP33779.
ProtClustDBCLSK893081.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
TIGRFAMsTIGR03697. NtcA_cyano. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTCA_SYNY3
AccessionPrimary (citable) accession number: P33779
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families