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P33779

- NTCA_SYNY3

UniProt

P33779 - NTCA_SYNY3

Protein

Global nitrogen regulator

Gene

ntcA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 131123cNMPAdd
    BLAST
    DNA bindingi177 – 19620H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Global nitrogen regulator
    Gene namesi
    Name:ntcA
    Ordered Locus Names:sll1423
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225Global nitrogen regulatorPRO_0000100187Add
    BLAST

    Proteomic databases

    PaxDbiP33779.

    Interactioni

    Protein-protein interaction databases

    IntActiP33779. 1 interaction.
    STRINGi1148.sll1423.

    Structurei

    3D structure databases

    ProteinModelPortaliP33779.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 21874HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000232503.
    OMAiRFFANEL.
    OrthoDBiEOG6QRWC5.
    PhylomeDBiP33779.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR022299. Tscrpt_reg_NtcA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33779-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQSLTQDRP LAAVFRRLGS ELMPPVVETF DRSKTIFFPG DPAERVYFLL    50
    KGAVKLSRVY EAGEEITVAL LRENSVFGVL SLVTGQRSDR FYHAVAFTPV 100
    ELLSAPIEQV EQALKEHPDL SLLMLQGLSS RILQTEMMIE TLAHRDMGSR 150
    LVSFLLILCR DFGVPAPDGI RIDLKLSHQA IAEAIGSTRV TVTRLLGDLR 200
    EGNMISITKK KITVHNPVAL SQQFT 225
    Length:225
    Mass (Da):25,046
    Last modified:February 1, 1994 - v1
    Checksum:iF1EE6555757E7379
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71607 Genomic DNA. Translation: CAA50607.1.
    BA000022 Genomic DNA. Translation: BAA18011.1.
    PIRiA48640.
    RefSeqiNP_441331.1. NC_000911.1.
    YP_005651388.1. NC_017277.1.
    YP_007451213.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18011; BAA18011; BAA18011.
    GeneIDi954677.
    KEGGisyn:sll1423.
    syy:SYNGTS_1435.
    syz:MYO_114480.
    PATRICi23840032. VBISynSp132158_1576.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71607 Genomic DNA. Translation: CAA50607.1 .
    BA000022 Genomic DNA. Translation: BAA18011.1 .
    PIRi A48640.
    RefSeqi NP_441331.1. NC_000911.1.
    YP_005651388.1. NC_017277.1.
    YP_007451213.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P33779.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P33779. 1 interaction.
    STRINGi 1148.sll1423.

    Proteomic databases

    PaxDbi P33779.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18011 ; BAA18011 ; BAA18011 .
    GeneIDi 954677.
    KEGGi syn:sll1423.
    syy:SYNGTS_1435.
    syz:MYO_114480.
    PATRICi 23840032. VBISynSp132158_1576.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000232503.
    OMAi RFFANEL.
    OrthoDBi EOG6QRWC5.
    PhylomeDBi P33779.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR022299. Tscrpt_reg_NtcA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    TIGRFAMsi TIGR03697. NtcA_cyano. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "General distribution of the nitrogen control gene ntcA in cyanobacteria."
      Frias J.E., Merida A., Herrero A., Martin-Nieto J.M., Flores E.
      J. Bacteriol. 175:5710-5713(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiNTCA_SYNY3
    AccessioniPrimary (citable) accession number: P33779
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3