Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P33766 (FPR1_MOUSE)

Last modified June 16, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    fMet-Leu-Phe receptor
      Short name=fMLP receptor
Alternative name(s):
    N-formyl peptide receptor
      Short name=FPR
    N-formylpeptide chemoattractant receptor
Gene names
Name: Fpr1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylated; which is necessary for desensitization By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364fMet-Leu-Phe receptor
PRO_0000069446

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 58231 Potential
Topological domain59 – 6911Cytoplasmic Potential
Transmembrane70 – 91222 Potential
Topological domain92 – 10817Extracellular Potential
Transmembrane109 – 129213 Potential
Topological domain130 – 14819Cytoplasmic Potential
Transmembrane149 – 170224 Potential
Topological domain171 – 21646Extracellular Potential
Transmembrane217 – 237215 Potential
Topological domain238 – 25316Cytoplasmic Potential
Transmembrane254 – 277246 Potential
Topological domain278 – 29619Extracellular Potential
Transmembrane297 – 316207 Potential
Topological domain317 – 36448Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 187 Potential

Sequences

Sequence LengthMass (Da)Tools
P33766-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 2F59193CF1D74DB2

FASTA36440,327
        10         20         30         40         50         60 
MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL GNGLVIWVAG 

        70         80         90        100        110        120 
FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP FGWFMCKFIY TVIDINLFGS 

       130        140        150        160        170        180 
VFLIALIALD RCICVLHPVW AQNHRTVSLA KKVIIVPWIC AFLLTLPVII RLTTVPNSRL 

       190        200        210        220        230        240 
GPGKTACTFD FSPWTKDPVE KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH 

       250        260        270        280        290        300 
RQGLIKSSRP LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL 

       310        320        330        340        350        360 
AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG TNSTSLSENT 


LNAM 

« Hide

References

[1]"Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains."
Gao J.-L., Murphy P.M.
J. Biol. Chem. 268:25395-25401(1993) [PubMed: 8244972] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

L22181 Unassigned DNA. Translation: AAA16110.1.
IPIIPI00114738.
PIRA49542.
RefSeqNP_038549.1.
UniGeneMm.56951

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP33766.

Proteomic databases

PRIDEP33766.

Genome annotation databases

EnsemblENSMUSG00000045551. Mus musculus. [Contig view]
GeneID14293.
KEGGmmu:14293.

Organism-specific databases

MGIMGI:107443. Fpr1.

Phylogenomic databases

HOGENOMP33766.
HOVERGENP33766.
OMAP33766. HKQGLIK.

Gene expression databases

ArrayExpressP33766.
BgeeP33766.
CleanExMM_FPR1.
GermOnlineENSMUSG00000045551. Mus musculus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR015691. fMet-Leu-Phe_recept-1.
IPR000826. Frt_met_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PANTHERPTHR19264:SF222. fMet-Leu-Phe_recept-1. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00526. FMETLEUPHER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio285695.
SOURCESearch...

Entry information

Entry nameFPR1_MOUSE
AccessionPrimary (citable) accession number: P33766
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents