P33766 (FPR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
fMet-Leu-Phe receptor
Short name=fMLP receptor

Alternative name(s):
N-formyl peptide receptor
Short name=FPR
N-formylpeptide chemoattractant receptor

Gene names

Name:

Fpr1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ. Ref.5
Post-translational modification	Phosphorylated; which is necessary for desensitization By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Traceable author statement PubMed 12470609. Source: MGI superoxide anion generation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	N-formyl peptide receptor activity Inferred from sequence orthology PubMed 12218158. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	fMet-Leu-Phe receptor		PRO_0000069446
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 58	23	Helical; Name=1; Potential
	Topological domain	59 – 69	11	Cytoplasmic Potential
	Transmembrane	70 – 91	22	Helical; Name=2; Potential
	Topological domain	92 – 108	17	Extracellular Potential
	Transmembrane	109 – 129	21	Helical; Name=3; Potential
	Topological domain	130 – 148	19	Cytoplasmic Potential
	Transmembrane	149 – 170	22	Helical; Name=4; Potential
	Topological domain	171 – 216	46	Extracellular Potential
	Transmembrane	217 – 237	21	Helical; Name=5; Potential
	Topological domain	238 – 253	16	Cytoplasmic Potential
	Transmembrane	254 – 277	24	Helical; Name=6; Potential
	Topological domain	278 – 296	19	Extracellular Potential
	Transmembrane	297 – 316	20	Helical; Name=7; Potential
	Topological domain	317 – 364	48	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 187		Potential

Sequences

	Sequence		Length	Mass (Da)
	P33766 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 2F59193CF1D74DB2	FASTA	364	40,327
	10 20 30 40 50 60 MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL GNGLVIWVAG 70 80 90 100 110 120 FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP FGWFMCKFIY TVIDINLFGS 130 140 150 160 170 180 VFLIALIALD RCICVLHPVW AQNHRTVSLA KKVIIVPWIC AFLLTLPVII RLTTVPNSRL 190 200 210 220 230 240 GPGKTACTFD FSPWTKDPVE KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH 250 260 270 280 290 300 RQGLIKSSRP LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL 310 320 330 340 350 360 AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG TNSTSLSENT LNAM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains." Gao J.-L., Murphy P.M. J. Biol. Chem. 268:25395-25401(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Vagina.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses." Migeotte I., Communi D., Parmentier M. Cytokine Growth Factor Rev. 17:501-519(2006) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[5]	"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ." Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22181 Unassigned DNA. Translation: AAA16110.1. AK137714 mRNA. Translation: BAE23472.1. CH466642 Genomic DNA. Translation: EDL20512.1.
IPI	IPI00114738.
PIR	A49542.
RefSeq	NP_038549.1. NM_013521.2.
UniGene	Mm.56951.
3D structure databases
ProteinModelPortal	P33766.
SMR	P33766. Positions 35-327.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000052894.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P33766.
Proteomic databases
PRIDE	P33766.
Protocols and materials databases
DNASU	14293.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000061516; ENSMUSP00000052894; ENSMUSG00000045551.
GeneID	14293.
KEGG	mmu:14293.
UCSC	uc008apt.1. mouse.
Organism-specific databases
CTD	2357.
MGI	MGI:107443. Fpr1.
Phylogenomic databases
eggNOG	NOG150376.
GeneTree	ENSGT00630000089620.
HOGENOM	HOG000234122.
HOVERGEN	HBG107927.
InParanoid	Q3UV01.
KO	K04172.
OMA	VCVLHPV.
OrthoDB	EOG4SQWWZ.
Gene expression databases
Bgee	P33766.
CleanEx	MM_FPR1.
Genevestigator	P33766.
GermOnline	ENSMUSG00000045551. Mus musculus.
Family and domain databases
InterPro	IPR027345. Formyl_pep_1_rcpt. IPR000826. Formyl_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24225. PTHR24225. 1 hit. PTHR24225:SF15. PTHR24225:SF15. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1770037.
NextBio	285695.
SOURCE	Search...

Entry information

Entry name

FPR1_MOUSE

Accession

Primary (citable) accession number: P33766
Secondary accession number(s): Q3UV01

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program