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P33766

- FPR1_MOUSE

UniProt

P33766 - FPR1_MOUSE

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Protein
fMet-Leu-Phe receptor
Gene
Fpr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. chemotaxis Source: MGI
  3. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
fMet-Leu-Phe receptor
Short name:
fMLP receptor
Alternative name(s):
N-formyl peptide receptor
Short name:
FPR
N-formylpeptide chemoattractant receptor
Gene namesi
Name:Fpr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:107443. Fpr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Extracellular Reviewed prediction
Add
BLAST
Transmembranei36 – 5823Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini59 – 6911Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei70 – 9122Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini92 – 10817Extracellular Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini130 – 14819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei149 – 17022Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini171 – 21646Extracellular Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini238 – 25316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei254 – 27724Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini278 – 29619Extracellular Reviewed prediction
Add
BLAST
Transmembranei297 – 31620Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini317 – 36448Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364fMet-Leu-Phe receptor
PRO_0000069446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 187 Reviewed prediction

Post-translational modificationi

Phosphorylated; which is necessary for desensitization By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP33766.

PTM databases

PhosphoSiteiP33766.

Expressioni

Tissue specificityi

Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.1 Publication

Gene expression databases

BgeeiP33766.
CleanExiMM_FPR1.
GenevestigatoriP33766.

Interactioni

Protein-protein interaction databases

MINTiMINT-127948.
STRINGi10090.ENSMUSP00000052894.

Structurei

3D structure databases

ProteinModelPortaliP33766.
SMRiP33766. Positions 21-320.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00730000110302.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiQ3UV01.
KOiK04172.
OMAiVIIGPWV.
OrthoDBiEOG77DJ6B.
PhylomeDBiP33766.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33766-1 [UniParc]FASTAAdd to Basket

« Hide

MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL    50
GNGLVIWVAG FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP 100
FGWFMCKFIY TVIDINLFGS VFLIALIALD RCICVLHPVW AQNHRTVSLA 150
KKVIIVPWIC AFLLTLPVII RLTTVPNSRL GPGKTACTFD FSPWTKDPVE 200
KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH RQGLIKSSRP 250
LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL 300
AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG 350
TNSTSLSENT LNAM 364
Length:364
Mass (Da):40,327
Last modified:February 1, 1994 - v1
Checksum:i2F59193CF1D74DB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22181 Unassigned DNA. Translation: AAA16110.1.
AK137714 mRNA. Translation: BAE23472.1.
CH466642 Genomic DNA. Translation: EDL20512.1.
CCDSiCCDS28418.1.
PIRiA49542.
RefSeqiNP_038549.1. NM_013521.2.
UniGeneiMm.56951.

Genome annotation databases

EnsembliENSMUST00000061516; ENSMUSP00000052894; ENSMUSG00000045551.
GeneIDi14293.
KEGGimmu:14293.
UCSCiuc008apt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22181 Unassigned DNA. Translation: AAA16110.1 .
AK137714 mRNA. Translation: BAE23472.1 .
CH466642 Genomic DNA. Translation: EDL20512.1 .
CCDSi CCDS28418.1.
PIRi A49542.
RefSeqi NP_038549.1. NM_013521.2.
UniGenei Mm.56951.

3D structure databases

ProteinModelPortali P33766.
SMRi P33766. Positions 21-320.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-127948.
STRINGi 10090.ENSMUSP00000052894.

Chemistry

ChEMBLi CHEMBL1770037.
GuidetoPHARMACOLOGYi 222.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P33766.

Proteomic databases

PRIDEi P33766.

Protocols and materials databases

DNASUi 14293.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061516 ; ENSMUSP00000052894 ; ENSMUSG00000045551 .
GeneIDi 14293.
KEGGi mmu:14293.
UCSCi uc008apt.1. mouse.

Organism-specific databases

CTDi 2357.
MGIi MGI:107443. Fpr1.

Phylogenomic databases

eggNOGi NOG150376.
GeneTreei ENSGT00730000110302.
HOGENOMi HOG000234122.
HOVERGENi HBG107927.
InParanoidi Q3UV01.
KOi K04172.
OMAi VIIGPWV.
OrthoDBi EOG77DJ6B.
PhylomeDBi P33766.
TreeFami TF330976.

Miscellaneous databases

NextBioi 285695.
PROi P33766.
SOURCEi Search...

Gene expression databases

Bgeei P33766.
CleanExi MM_FPR1.
Genevestigatori P33766.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains."
    Gao J.-L., Murphy P.M.
    J. Biol. Chem. 268:25395-25401(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Vagina.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses."
    Migeotte I., Communi D., Parmentier M.
    Cytokine Growth Factor Rev. 17:501-519(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPR1_MOUSE
AccessioniPrimary (citable) accession number: P33766
Secondary accession number(s): Q3UV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi