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P33766

- FPR1_MOUSE

UniProt

P33766 - FPR1_MOUSE

Protein

fMet-Leu-Phe receptor

Gene

Fpr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.

    GO - Molecular functioni

    1. N-formyl peptide receptor activity Source: MGI

    GO - Biological processi

    1. chemotaxis Source: MGI
    2. G-protein coupled receptor signaling pathway Source: MGI
    3. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    fMet-Leu-Phe receptor
    Short name:
    fMLP receptor
    Alternative name(s):
    N-formyl peptide receptor
    Short name:
    FPR
    N-formylpeptide chemoattractant receptor
    Gene namesi
    Name:Fpr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:107443. Fpr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364fMet-Leu-Phe receptorPRO_0000069446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 187PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated; which is necessary for desensitization.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP33766.

    PTM databases

    PhosphoSiteiP33766.

    Expressioni

    Tissue specificityi

    Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.1 Publication

    Gene expression databases

    BgeeiP33766.
    CleanExiMM_FPR1.
    GenevestigatoriP33766.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-127948.
    STRINGi10090.ENSMUSP00000052894.

    Structurei

    3D structure databases

    ProteinModelPortaliP33766.
    SMRiP33766. Positions 21-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini59 – 6911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini92 – 10817ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 21646ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 29619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini317 – 36448CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5823Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 9122Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 17022Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27724Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31620Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    GeneTreeiENSGT00730000110302.
    HOGENOMiHOG000234122.
    HOVERGENiHBG107927.
    InParanoidiQ3UV01.
    KOiK04172.
    OMAiVIIGPWV.
    OrthoDBiEOG77DJ6B.
    PhylomeDBiP33766.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR027345. Formyl_pep_1_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF15. PTHR24225:SF15. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P33766-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL    50
    GNGLVIWVAG FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP 100
    FGWFMCKFIY TVIDINLFGS VFLIALIALD RCICVLHPVW AQNHRTVSLA 150
    KKVIIVPWIC AFLLTLPVII RLTTVPNSRL GPGKTACTFD FSPWTKDPVE 200
    KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH RQGLIKSSRP 250
    LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL 300
    AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG 350
    TNSTSLSENT LNAM 364
    Length:364
    Mass (Da):40,327
    Last modified:February 1, 1994 - v1
    Checksum:i2F59193CF1D74DB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22181 Unassigned DNA. Translation: AAA16110.1.
    AK137714 mRNA. Translation: BAE23472.1.
    CH466642 Genomic DNA. Translation: EDL20512.1.
    CCDSiCCDS28418.1.
    PIRiA49542.
    RefSeqiNP_038549.1. NM_013521.2.
    UniGeneiMm.56951.

    Genome annotation databases

    EnsembliENSMUST00000061516; ENSMUSP00000052894; ENSMUSG00000045551.
    GeneIDi14293.
    KEGGimmu:14293.
    UCSCiuc008apt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L22181 Unassigned DNA. Translation: AAA16110.1 .
    AK137714 mRNA. Translation: BAE23472.1 .
    CH466642 Genomic DNA. Translation: EDL20512.1 .
    CCDSi CCDS28418.1.
    PIRi A49542.
    RefSeqi NP_038549.1. NM_013521.2.
    UniGenei Mm.56951.

    3D structure databases

    ProteinModelPortali P33766.
    SMRi P33766. Positions 21-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-127948.
    STRINGi 10090.ENSMUSP00000052894.

    Chemistry

    ChEMBLi CHEMBL1770037.
    GuidetoPHARMACOLOGYi 222.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P33766.

    Proteomic databases

    PRIDEi P33766.

    Protocols and materials databases

    DNASUi 14293.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061516 ; ENSMUSP00000052894 ; ENSMUSG00000045551 .
    GeneIDi 14293.
    KEGGi mmu:14293.
    UCSCi uc008apt.1. mouse.

    Organism-specific databases

    CTDi 2357.
    MGIi MGI:107443. Fpr1.

    Phylogenomic databases

    eggNOGi NOG150376.
    GeneTreei ENSGT00730000110302.
    HOGENOMi HOG000234122.
    HOVERGENi HBG107927.
    InParanoidi Q3UV01.
    KOi K04172.
    OMAi VIIGPWV.
    OrthoDBi EOG77DJ6B.
    PhylomeDBi P33766.
    TreeFami TF330976.

    Miscellaneous databases

    NextBioi 285695.
    PROi P33766.
    SOURCEi Search...

    Gene expression databases

    Bgeei P33766.
    CleanExi MM_FPR1.
    Genevestigatori P33766.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR027345. Formyl_pep_1_rcpt.
    IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    PTHR24225:SF15. PTHR24225:SF15. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains."
      Gao J.-L., Murphy P.M.
      J. Biol. Chem. 268:25395-25401(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Vagina.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses."
      Migeotte I., Communi D., Parmentier M.
      Cytokine Growth Factor Rev. 17:501-519(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    5. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFPR1_MOUSE
    AccessioniPrimary (citable) accession number: P33766
    Secondary accession number(s): Q3UV01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3