Reviewed, UniProtKB/Swiss-Prot P33766 (FPR1_MOUSE)

Names and origin

Protein names

Recommended name:
    fMet-Leu-Phe receptor
      Short name=fMLP receptor
Alternative name(s):
    N-formyl peptide receptor
      Short name=FPR
    N-formylpeptide chemoattractant receptor

Gene names

Name:

Fpr1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Phosphorylated; which is necessary for desensitization By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from direct assay. Source: MGI chemotaxis Traceable author statement. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-formyl peptide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	fMet-Leu-Phe receptor		PRO_0000069446
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 58	23	1 Potential
	Topological domain	59 – 69	11	Cytoplasmic Potential
	Transmembrane	70 – 91	22	2 Potential
	Topological domain	92 – 108	17	Extracellular Potential
	Transmembrane	109 – 129	21	3 Potential
	Topological domain	130 – 148	19	Cytoplasmic Potential
	Transmembrane	149 – 170	22	4 Potential
	Topological domain	171 – 216	46	Extracellular Potential
	Transmembrane	217 – 237	21	5 Potential
	Topological domain	238 – 253	16	Cytoplasmic Potential
	Transmembrane	254 – 277	24	6 Potential
	Topological domain	278 – 296	19	Extracellular Potential
	Transmembrane	297 – 316	20	7 Potential
	Topological domain	317 – 364	48	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 187		Potential

Sequences

	Sequence		Length	Mass (Da)
	P33766-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 2F59193CF1D74DB2	FASTA	364	40,327
	10 20 30 40 50 60 MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL GNGLVIWVAG 70 80 90 100 110 120 FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP FGWFMCKFIY TVIDINLFGS 130 140 150 160 170 180 VFLIALIALD RCICVLHPVW AQNHRTVSLA KKVIIVPWIC AFLLTLPVII RLTTVPNSRL 190 200 210 220 230 240 GPGKTACTFD FSPWTKDPVE KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH 250 260 270 280 290 300 RQGLIKSSRP LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL 310 320 330 340 350 360 AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG TNSTSLSENT LNAM

References

[1]	"Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains." Gao J.-L., Murphy P.M. J. Biol. Chem. 268:25395-25401(1993) [PubMed: 8244972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L22181 Unassigned DNA. Translation: AAA16110.1.
IPI	IPI00114738.
PIR	A49542.
RefSeq	NP_038549.1.
UniGene	Mm.56951
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P33766.
Proteomic databases
PRIDE	P33766.
Genome annotation databases
Ensembl	ENSMUSG00000045551. Mus musculus. [Contig view]
GeneID	14293.
KEGG	mmu:14293.
Organism-specific databases
MGI	MGI:107443. Fpr1.
Phylogenomic databases
HOGENOM	P33766.
HOVERGEN	P33766.
OMA	P33766. HKQGLIK.
Gene expression databases
ArrayExpress	P33766.
Bgee	P33766.
CleanEx	MM_FPR1.
GermOnline	ENSMUSG00000045551. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR015691. fMet-Leu-Phe_recept-1. IPR000826. Frt_met_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19264:SF222. fMet-Leu-Phe_recept-1. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	285695.
SOURCE	Search...

Entry information

Entry name

FPR1_MOUSE

Accession

Primary (citable) accession number: P33766

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)