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P33766

- FPR1_MOUSE

UniProt

P33766 - FPR1_MOUSE

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Protein

fMet-Leu-Phe receptor

Gene

Fpr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: MGI

GO - Biological processi

  1. chemotaxis Source: MGI
  2. G-protein coupled receptor signaling pathway Source: MGI
  3. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_229705. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
fMet-Leu-Phe receptor
Short name:
fMLP receptor
Alternative name(s):
N-formyl peptide receptor
Short name:
FPR
N-formylpeptide chemoattractant receptor
Gene namesi
Name:Fpr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:107443. Fpr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5823Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini59 – 6911CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9122Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 10817ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 17022Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 21646ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 25316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei254 – 27724Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini278 – 29619ExtracellularSequence AnalysisAdd
BLAST
Transmembranei297 – 31620Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini317 – 36448CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364fMet-Leu-Phe receptorPRO_0000069446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 187PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated; which is necessary for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP33766.

PTM databases

PhosphoSiteiP33766.

Expressioni

Tissue specificityi

Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.1 Publication

Gene expression databases

BgeeiP33766.
CleanExiMM_FPR1.
GenevestigatoriP33766.

Interactioni

Protein-protein interaction databases

MINTiMINT-127948.
STRINGi10090.ENSMUSP00000052894.

Structurei

3D structure databases

ProteinModelPortaliP33766.
SMRiP33766. Positions 21-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP33766.
KOiK04172.
OMAiVIIGPWV.
OrthoDBiEOG77DJ6B.
PhylomeDBiP33766.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P33766-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL
60 70 80 90 100
GNGLVIWVAG FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP
110 120 130 140 150
FGWFMCKFIY TVIDINLFGS VFLIALIALD RCICVLHPVW AQNHRTVSLA
160 170 180 190 200
KKVIIVPWIC AFLLTLPVII RLTTVPNSRL GPGKTACTFD FSPWTKDPVE
210 220 230 240 250
KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH RQGLIKSSRP
260 270 280 290 300
LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL
310 320 330 340 350
AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG
360
TNSTSLSENT LNAM
Length:364
Mass (Da):40,327
Last modified:February 1, 1994 - v1
Checksum:i2F59193CF1D74DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22181 Unassigned DNA. Translation: AAA16110.1.
AK137714 mRNA. Translation: BAE23472.1.
CH466642 Genomic DNA. Translation: EDL20512.1.
CCDSiCCDS28418.1.
PIRiA49542.
RefSeqiNP_038549.1. NM_013521.2.
UniGeneiMm.56951.

Genome annotation databases

EnsembliENSMUST00000061516; ENSMUSP00000052894; ENSMUSG00000045551.
GeneIDi14293.
KEGGimmu:14293.
UCSCiuc008apt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22181 Unassigned DNA. Translation: AAA16110.1 .
AK137714 mRNA. Translation: BAE23472.1 .
CH466642 Genomic DNA. Translation: EDL20512.1 .
CCDSi CCDS28418.1.
PIRi A49542.
RefSeqi NP_038549.1. NM_013521.2.
UniGenei Mm.56951.

3D structure databases

ProteinModelPortali P33766.
SMRi P33766. Positions 21-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-127948.
STRINGi 10090.ENSMUSP00000052894.

Chemistry

BindingDBi P33766.
ChEMBLi CHEMBL1770037.
GuidetoPHARMACOLOGYi 222.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P33766.

Proteomic databases

PRIDEi P33766.

Protocols and materials databases

DNASUi 14293.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061516 ; ENSMUSP00000052894 ; ENSMUSG00000045551 .
GeneIDi 14293.
KEGGi mmu:14293.
UCSCi uc008apt.1. mouse.

Organism-specific databases

CTDi 2357.
MGIi MGI:107443. Fpr1.

Phylogenomic databases

eggNOGi NOG150376.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000234122.
HOVERGENi HBG107927.
InParanoidi P33766.
KOi K04172.
OMAi VIIGPWV.
OrthoDBi EOG77DJ6B.
PhylomeDBi P33766.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_229705. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi 285695.
PROi P33766.
SOURCEi Search...

Gene expression databases

Bgeei P33766.
CleanExi MM_FPR1.
Genevestigatori P33766.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains."
    Gao J.-L., Murphy P.M.
    J. Biol. Chem. 268:25395-25401(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Vagina.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses."
    Migeotte I., Communi D., Parmentier M.
    Cytokine Growth Factor Rev. 17:501-519(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  5. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPR1_MOUSE
AccessioniPrimary (citable) accession number: P33766
Secondary accession number(s): Q3UV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3