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Protein

fMet-Leu-Phe receptor

Gene

Fpr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
fMet-Leu-Phe receptor
Short name:
fMLP receptor
Alternative name(s):
N-formyl peptide receptor
Short name:
FPR
N-formylpeptide chemoattractant receptor
Gene namesi
Name:Fpr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:107443 Fpr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 58Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini59 – 69CytoplasmicSequence analysisAdd BLAST11
Transmembranei70 – 91Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini92 – 108ExtracellularSequence analysisAdd BLAST17
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 148CytoplasmicSequence analysisAdd BLAST19
Transmembranei149 – 170Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini171 – 216ExtracellularSequence analysisAdd BLAST46
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 253CytoplasmicSequence analysisAdd BLAST16
Transmembranei254 – 277Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini278 – 296ExtracellularSequence analysisAdd BLAST19
Transmembranei297 – 316Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini317 – 364CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1770037
GuidetoPHARMACOLOGYi222

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694461 – 364fMet-Leu-Phe receptorAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 187PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated; which is necessary for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP33766
PaxDbiP33766
PRIDEiP33766

PTM databases

iPTMnetiP33766
PhosphoSitePlusiP33766

Expressioni

Tissue specificityi

Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.1 Publication

Gene expression databases

BgeeiENSMUSG00000045551
CleanExiMM_FPR1
GenevisibleiP33766 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052894

Chemistry databases

BindingDBiP33766

Structurei

3D structure databases

ProteinModelPortaliP33766
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiP33766
KOiK04172
OMAiGHWPFGW
OrthoDBiEOG091G09ZK
PhylomeDBiP33766
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR027345 Formyl_pep_1_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF15 PTHR24225:SF15, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P33766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL
60 70 80 90 100
GNGLVIWVAG FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP
110 120 130 140 150
FGWFMCKFIY TVIDINLFGS VFLIALIALD RCICVLHPVW AQNHRTVSLA
160 170 180 190 200
KKVIIVPWIC AFLLTLPVII RLTTVPNSRL GPGKTACTFD FSPWTKDPVE
210 220 230 240 250
KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH RQGLIKSSRP
260 270 280 290 300
LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL
310 320 330 340 350
AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG
360
TNSTSLSENT LNAM
Length:364
Mass (Da):40,327
Last modified:February 1, 1994 - v1
Checksum:i2F59193CF1D74DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22181 Unassigned DNA Translation: AAA16110.1
AK137714 mRNA Translation: BAE23472.1
CH466642 Genomic DNA Translation: EDL20512.1
CCDSiCCDS28418.1
PIRiA49542
RefSeqiNP_038549.1, NM_013521.2
UniGeneiMm.56951

Genome annotation databases

EnsembliENSMUST00000061516; ENSMUSP00000052894; ENSMUSG00000045551
GeneIDi14293
KEGGimmu:14293
UCSCiuc008apt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFPR1_MOUSE
AccessioniPrimary (citable) accession number: P33766
Secondary accession number(s): Q3UV01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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