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P33765

- AA3R_HUMAN

UniProt

P33765 - AA3R_HUMAN

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Protein
Adenosine receptor A3
Gene
ADORA3, UNQ1931/PRO4406
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. activation of adenylate cyclase activity Source: ProtInc
  2. histamine secretion by mast cell Source: Ensembl
  3. inflammatory response Source: ProtInc
  4. positive regulation of calcium-mediated signaling Source: Ensembl
  5. positive regulation of inflammatory response Source: Ensembl
  6. positive regulation of leukocyte migration Source: Ensembl
  7. positive regulation of mast cell degranulation Source: Ensembl
  8. positive regulation of mucus secretion Source: Ensembl
  9. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  10. regulation of heart contraction Source: ProtInc
  11. response to wounding Source: ProtInc
  12. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18288. Adenosine P1 receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A3
Gene namesi
Name:ADORA3
ORF Names:UNQ1931/PRO4406
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:268. ADORA3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414Extracellular By similarity
Add
BLAST
Transmembranei15 – 3723Helical; Name=1; By similarity
Add
BLAST
Topological domaini38 – 4811Cytoplasmic By similarity
Add
BLAST
Transmembranei49 – 7224Helical; Name=2; By similarity
Add
BLAST
Topological domaini73 – 8412Extracellular By similarity
Add
BLAST
Transmembranei85 – 10622Helical; Name=3; By similarity
Add
BLAST
Topological domaini107 – 12620Cytoplasmic By similarity
Add
BLAST
Transmembranei127 – 14822Helical; Name=4; By similarity
Add
BLAST
Topological domaini149 – 17729Extracellular By similarity
Add
BLAST
Transmembranei178 – 19821Helical; Name=5; By similarity
Add
BLAST
Topological domaini199 – 23133Cytoplasmic By similarity
Add
BLAST
Transmembranei232 – 25524Helical; Name=6; By similarity
Add
BLAST
Topological domaini256 – 2616Extracellular By similarity
Transmembranei262 – 28423Helical; Name=7; By similarity
Add
BLAST
Topological domaini285 – 31834Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. mast cell granule Source: GOC
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Adenosine receptor A3
PRO_0000069010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi12 – 121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi83 ↔ 166 By similarity
Lipidationi303 – 3031S-palmitoyl cysteine Reviewed prediction

Post-translational modificationi

Phosphorylation on Ser-317 may be crucial for rapid desensitization By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP33765.
PRIDEiP33765.

PTM databases

PhosphoSiteiP33765.

Expressioni

Gene expression databases

ArrayExpressiP33765.
BgeeiP33765.
CleanExiHS_ADORA3.
GenevestigatoriP33765.

Organism-specific databases

HPAiHPA028509.
HPA028566.
HPA028568.

Interactioni

Protein-protein interaction databases

BioGridi106650. 2 interactions.
STRINGi9606.ENSP00000358730.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OEAmodel-A1-298[»]
1R7Nmodel-A1-318[»]
ProteinModelPortaliP33765.
SMRiP33765. Positions 10-302.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133889.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
KOiK04268.
OMAiQEVARMQ.
PhylomeDBiP33765.
TreeFamiTF334441.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P33765-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF    50
IVSLALADIA VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS 100
LLAIAVDRYL RVKLTVRYKR VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN 150
MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF SFLTWIFIPL VVMCAIYLDI 200
FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA LSWLPLSIIN 250
CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC 300
VVCHPSDSLD TSIEKNSE 318
Length:318
Mass (Da):36,185
Last modified:February 1, 1996 - v2
Checksum:i690E67986130FC28
GO
Isoform 2 (identifier: P33765-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-318: YKRVTTHRRI...LDTSIEKNSE → FRIPGLPGCI...PKEMAPTEQM

Show »
Length:347
Mass (Da):38,976
Checksum:i7F4974135F4F04A6
GO
Isoform 3 (identifier: Q6P2N6-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q6P2N6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:266
Mass (Da):30,327
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035755
Natural varianti248 – 2481I → L.1 Publication
Corresponds to variant rs35511654 [ dbSNP | Ensembl ].
VAR_049366
Natural varianti266 – 2661M → K.
Corresponds to variant rs2800889 [ dbSNP | Ensembl ].
VAR_049367

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 318201YKRVT…EKNSE → FRIPGLPGCILSFQLKVCFL PVMWLFILLSLALISDAMVM DEKVKRSFVLDTASAICNYN AHYKNHPKYWCRGYFRDYCN IIAFSPNSTNHVALRDTGNQ LIVTMSCLTKEDTGWYWCGI QRDFARDDMDFTELIVTDDK GTLANDFWSGKDLSGNKTRS CKAPKVVRKADRSRTSILII CILITGLGIISVISHLTKRR RSQRNRRVGNTLKPFSRVLT PKEMAPTEQM in isoform 2.
VSP_013320Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71A → T in AAA16365. 1 Publication
Sequence conflicti175 – 1751D → V1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20463 mRNA. Translation: AAA16365.1.
L22607 mRNA. Translation: AAA35949.1.
X76981 mRNA. Translation: CAA54288.1.
L77730, L77729 Genomic DNA. Translation: AAB02790.1.
AY136749 mRNA. Translation: AAN01275.1.
AY358644 mRNA. Translation: AAQ89007.1.
AL390195 Genomic DNA. Translation: CAC36045.1.
AL390195 Genomic DNA. Translation: CAM21993.1.
BC029831 mRNA. Translation: AAH29831.1.
AY011231 Genomic DNA. Translation: AAG35155.1.
CCDSiCCDS838.1. [P33765-2]
CCDS839.1. [P33765-1]
PIRiS38511.
RefSeqiNP_000668.1. NM_000677.3. [P33765-1]
NP_065734.5. NM_020683.6. [P33765-2]
UniGeneiHs.281342.

Genome annotation databases

EnsembliENST00000241356; ENSP00000241356; ENSG00000121933. [P33765-1]
ENST00000369716; ENSP00000358730; ENSG00000121933. [P33765-2]
GeneIDi140.
KEGGihsa:140.
UCSCiuc001ebf.3. human. [P33765-2]
uc001ebh.4. human. [P33765-1]

Polymorphism databases

DMDMi1351831.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20463 mRNA. Translation: AAA16365.1 .
L22607 mRNA. Translation: AAA35949.1 .
X76981 mRNA. Translation: CAA54288.1 .
L77730 , L77729 Genomic DNA. Translation: AAB02790.1 .
AY136749 mRNA. Translation: AAN01275.1 .
AY358644 mRNA. Translation: AAQ89007.1 .
AL390195 Genomic DNA. Translation: CAC36045.1 .
AL390195 Genomic DNA. Translation: CAM21993.1 .
BC029831 mRNA. Translation: AAH29831.1 .
AY011231 Genomic DNA. Translation: AAG35155.1 .
CCDSi CCDS838.1. [P33765-2 ]
CCDS839.1. [P33765-1 ]
PIRi S38511.
RefSeqi NP_000668.1. NM_000677.3. [P33765-1 ]
NP_065734.5. NM_020683.6. [P33765-2 ]
UniGenei Hs.281342.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OEA model - A 1-298 [» ]
1R7N model - A 1-318 [» ]
ProteinModelPortali P33765.
SMRi P33765. Positions 10-302.
ModBasei Search...

Protein-protein interaction databases

BioGridi 106650. 2 interactions.
STRINGi 9606.ENSP00000358730.

Chemistry

BindingDBi P33765.
ChEMBLi CHEMBL2095195.
DrugBanki DB00640. Adenosine.
DB01223. Aminophylline.
GuidetoPHARMACOLOGYi 21.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P33765.

Polymorphism databases

DMDMi 1351831.

Proteomic databases

PaxDbi P33765.
PRIDEi P33765.

Protocols and materials databases

DNASUi 140.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000241356 ; ENSP00000241356 ; ENSG00000121933 . [P33765-1 ]
ENST00000369716 ; ENSP00000358730 ; ENSG00000121933 . [P33765-2 ]
GeneIDi 140.
KEGGi hsa:140.
UCSCi uc001ebf.3. human. [P33765-2 ]
uc001ebh.4. human. [P33765-1 ]

Organism-specific databases

CTDi 140.
GeneCardsi GC01M112025.
HGNCi HGNC:268. ADORA3.
HPAi HPA028509.
HPA028566.
HPA028568.
MIMi 600445. gene.
neXtProti NX_P33765.
PharmGKBi PA24589.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG133889.
HOGENOMi HOG000015770.
HOVERGENi HBG106962.
KOi K04268.
OMAi QEVARMQ.
PhylomeDBi P33765.
TreeFami TF334441.

Enzyme and pathway databases

Reactomei REACT_18288. Adenosine P1 receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Adenosine_A3_receptor.
GenomeRNAii 140.
NextBioi 553.
PROi P33765.
SOURCEi Search...

Gene expression databases

ArrayExpressi P33765.
Bgeei P33765.
CleanExi HS_ADORA3.
Genevestigatori P33765.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000466. Adeno_A3_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00555. ADENOSINEA3R.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and sequence analysis of the human A3 adenosine receptor."
    Sajjadi F.G., Firestein G.S.
    Biochim. Biophys. Acta 1179:105-107(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "Molecular cloning and characterization of the human A3 adenosine receptor."
    Salvatore C.A., Jacobson M.A., Taylor H.E., Linden J., Johnson R.G.
    Proc. Natl. Acad. Sci. U.S.A. 90:10365-10369(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Meyerehof W., Hamm B., Schoenrock C., Fehr S., Wulfsen I., Richter D.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-248.
    Tissue: Testis.
  4. Atkinson M.R., Townsend-Nicholson A., Nicholl J.K., Sutherland G.R., Schofield P.R.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Lung and Testis.
  9. "Molecular phylogenetics and the origins of placental mammals."
    Murphy W.J., Eizirik E., Johnson W.E., Zhang Y.-P., Ryder O.A., O'Brien S.J.
    Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 166-272 (ISOFORM 1).
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-105.

Entry informationi

Entry nameiAA3R_HUMAN
AccessioniPrimary (citable) accession number: P33765
Secondary accession number(s): A2A3P4, Q6UWU0, Q9BYZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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