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Protein

Protein S100-A3

Gene

S100A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc1
Metal bindingi86Zinc1
Metal bindingi87Zinc1
Metal bindingi93Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinitySequence analysisAdd BLAST14
Calcium bindingi63 – 742; high affinitySequence analysisAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A3
Alternative name(s):
Protein S-100E
S100 calcium-binding protein A3
Gene namesi
Name:S100A3
Synonyms:S100E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10493. S100A3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30C → A: Abolishes calcium binding; when associated with Ala-68. 1 Publication1
Mutagenesisi68C → A: Abolishes calcium binding; when associated with Ala-30. 1 Publication1
Mutagenesisi81C → A: Increases affinity for calcium; when associated with Ala-99. 1 Publication1
Mutagenesisi99C → A: Increases affinity for calcium; when associated with Ala-81. 1 Publication1

Organism-specific databases

DisGeNETi6274.
OpenTargetsiENSG00000188015.
PharmGKBiPA34905.

Polymorphism and mutation databases

BioMutaiS100A3.
DMDMi464729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001439722 – 101Protein S100-A3Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Disulfide bondi30 ↔ 681 Publication
Modified residuei51Citrulline; by PAD31 Publication1
Disulfide bondi81 ↔ 991 Publication

Post-translational modificationi

More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Disulfide bond

Proteomic databases

MaxQBiP33764.
PaxDbiP33764.
PeptideAtlasiP33764.
PRIDEiP33764.

Expressioni

Tissue specificityi

Skin specific, specifically expressed at the inner endocuticle of hair fibers.1 Publication

Gene expression databases

BgeeiENSG00000188015.
CleanExiHS_S100A3.
GenevisibleiP33764. HS.

Organism-specific databases

HPAiHPA042674.
HPA056140.

Interactioni

Subunit structurei

Homodimer and homotetramer for the citrullinated form.1 Publication

Protein-protein interaction databases

BioGridi112182. 16 interactors.
IntActiP33764. 2 interactors.
MINTiMINT-4714713.
STRINGi9606.ENSP00000357701.

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi22 – 24Combined sources3
Beta strandi28 – 30Combined sources3
Helixi31 – 41Combined sources11
Turni42 – 44Combined sources3
Turni49 – 51Combined sources3
Helixi52 – 64Combined sources13
Turni65 – 67Combined sources3
Beta strandi68 – 71Combined sources4
Helixi72 – 86Combined sources15
Helixi88 – 90Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSOX-ray1.70A/B1-101[»]
3NSIX-ray2.15A/B1-101[»]
3NSKX-ray1.55A/B1-101[»]
3NSLX-ray1.50A/B/C/D/E/F2-101[»]
3NSOX-ray1.45A/B1-101[»]
ProteinModelPortaliP33764.
SMRiP33764.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP33764.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1Add BLAST36
Domaini50 – 85EF-hand 2Add BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J3DW. Eukaryota.
ENOG411196G. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP33764.
OMAiYFKDCPP.
OrthoDBiEOG091G10JX.
PhylomeDBiP33764.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLEQAVA AIVCTFQEYA GRCGDKYKLC QAELKELLQK ELATWTPTEF
60 70 80 90 100
RECDYNKFMS VLDTNKDCEV DFVEYVRSLA CLCLYCHEYF KDCPSEPPCS

Q
Length:101
Mass (Da):11,713
Last modified:February 1, 1994 - v1
Checksum:iABCAF4B7E5F2E0A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0610473R → K.Corresponds to variant rs36022742dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18948 mRNA. Translation: CAA79471.1.
Z18950 Genomic DNA. Translation: CAA79473.1.
BT006955 mRNA. Translation: AAP35601.1.
CR542163 mRNA. Translation: CAG46960.1.
CR542185 mRNA. Translation: CAG46982.1.
BX470102 Genomic DNA. Translation: CAI14755.1.
CH471121 Genomic DNA. Translation: EAW53306.1.
CH471121 Genomic DNA. Translation: EAW53307.1.
BC012893 mRNA. Translation: AAH12893.1.
CCDSiCCDS1043.1.
PIRiC48219.
S70326.
RefSeqiNP_002951.1. NM_002960.1.
UniGeneiHs.557609.

Genome annotation databases

EnsembliENST00000368712; ENSP00000357701; ENSG00000188015.
ENST00000368713; ENSP00000357702; ENSG00000188015.
GeneIDi6274.
KEGGihsa:6274.
UCSCiuc001fca.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18948 mRNA. Translation: CAA79471.1.
Z18950 Genomic DNA. Translation: CAA79473.1.
BT006955 mRNA. Translation: AAP35601.1.
CR542163 mRNA. Translation: CAG46960.1.
CR542185 mRNA. Translation: CAG46982.1.
BX470102 Genomic DNA. Translation: CAI14755.1.
CH471121 Genomic DNA. Translation: EAW53306.1.
CH471121 Genomic DNA. Translation: EAW53307.1.
BC012893 mRNA. Translation: AAH12893.1.
CCDSiCCDS1043.1.
PIRiC48219.
S70326.
RefSeqiNP_002951.1. NM_002960.1.
UniGeneiHs.557609.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KSOX-ray1.70A/B1-101[»]
3NSIX-ray2.15A/B1-101[»]
3NSKX-ray1.55A/B1-101[»]
3NSLX-ray1.50A/B/C/D/E/F2-101[»]
3NSOX-ray1.45A/B1-101[»]
ProteinModelPortaliP33764.
SMRiP33764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112182. 16 interactors.
IntActiP33764. 2 interactors.
MINTiMINT-4714713.
STRINGi9606.ENSP00000357701.

Polymorphism and mutation databases

BioMutaiS100A3.
DMDMi464729.

Proteomic databases

MaxQBiP33764.
PaxDbiP33764.
PeptideAtlasiP33764.
PRIDEiP33764.

Protocols and materials databases

DNASUi6274.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368712; ENSP00000357701; ENSG00000188015.
ENST00000368713; ENSP00000357702; ENSG00000188015.
GeneIDi6274.
KEGGihsa:6274.
UCSCiuc001fca.2. human.

Organism-specific databases

CTDi6274.
DisGeNETi6274.
GeneCardsiS100A3.
H-InvDBHIX0116376.
HGNCiHGNC:10493. S100A3.
HPAiHPA042674.
HPA056140.
MIMi176992. gene.
neXtProtiNX_P33764.
OpenTargetsiENSG00000188015.
PharmGKBiPA34905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3DW. Eukaryota.
ENOG411196G. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP33764.
OMAiYFKDCPP.
OrthoDBiEOG091G10JX.
PhylomeDBiP33764.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP33764.
GeneWikiiS100A3.
GenomeRNAii6274.
PROiP33764.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188015.
CleanExiHS_S100A3.
GenevisibleiP33764. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028488. S100A3.
[Graphical view]
PANTHERiPTHR11639:SF12. PTHR11639:SF12. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10A3_HUMAN
AccessioniPrimary (citable) accession number: P33764
Secondary accession number(s): D3DV51, Q6FGE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.